Abstract: Means for transferring efficiently a desired nucleic acid into a cell is provided. The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired nucleic acid.

Abstract: Preparations for transferring efficiently oligonucleotides necessary in antisense therapy or the like into animal cells so as to be useful in treatment for various diseases, which comprises a collagen as an essential component are provided.

Abstract: Means for transferring efficiently a desired nucleic acid into a cell is provided. The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired nucleic acid.

Abstract: Preparations for transferring efficiently oligonucleotides necessary in antisense therapy or the like into animal cells so as to be useful in treatment for various diseases, which comprises a collagen as an essential component are provided.

Abstract: To provide a method for selecting a marker gene useful for cancer classification; a method for classifying cancer using the gene; a method for detecting cancer; a kit usable for the classification method or detection method; and a DNA array carrying the gene. According to the present invention, there can be obtained a gene, wherein expression of the above gene is altered independently from genes each of which expression is altered specifically during cell proliferation and expression level of the above gene is specifically altered depending on every type of cancer samples to be tested, whereby the classification or detection of cancer can be carried out conveniently and quickly without giving surgical treatment. Therefore, the present invention is useful for the diagnosis, the treatment, and the like of cancer.

Abstract: The invention is directed to the retention of the stability of formulations useful for a gene therapy during the preparation and preservation. In the invention, at least one saccharide and/or at least one non-hydrophobic amino acid and/or at least one organic acid having two or more carboxyl groups except amino acids, or a collagen or a gelatin and at least one amino acid are added to a gene formulation.

Abstract: The present invention relates to gene preparations comprising desired genes or vectors containing desired genes integrated there into and carriers for supporting the same. The carrier is preferably a soluble collagen such as atelocollagen and may further include an additive. The invention also encompasses methods for delivering genes to cells employing the gene preparation.

Abstract: To provide a method for selecting a marker gene useful for cancer classification; a method for classifying cancer using the gene; a method for detecting cancer; a kit usable for the classification method or detection method; and a DNA array carrying the gene. According to the present invention, there can be obtained a gene, wherein expression of the above gene is altered independently from genes each of which expression is altered specifically during cell proliferation and expression level of the above gene is specifically altered depending on every type of cancer samples to be tested, whereby the classification or detection of cancer can be carried out conveniently and quickly without giving surgical treatment. Therefore, the present invention is useful for the diagnosis, the treatment, and the like of cancer.

Abstract: Means for transferring efficiently a desired nucleic acid into a cell is provided.

Abstract: Preparations for transferring efficiently oligonucleotides necessary in antisense therapy or the like into animal cells so as to be useful in treatment for various diseases, which comprises a collagen as an essential component are provided.

Abstract: The present invention relates to gene preparations comprising desired genes or vectors containing desired genes integrated there into and carriers for supporting the same.

Abstract: The present invention relates to a genomic DNA library substantially maintaining copy numbers of a set of genes or the sequences on a genome, an abundance ratio of the set of genes or sequences on the genome, and the polymorphic patterns substantially identical to that of the genomic DNA. The present invention also relates to a method of producing the above genomic DNA library. The genomic DNA library of the present invention is useful in analysis of genetic polymorphism; genetic diagnosis of a disease; preparation of DNA arrays; preparation of samples for searching open reading frames in analysis such as genome analysis; preservation of genes of endangered organisms; gene specimens; mutation analysis; nucleotide sequence analysis; analysis by hybridization methods such as Southern blot hybridization method, dot blot hybridization method, Northern blot hybridization method, macroarray hybridization methods using membrane and the like, or DNA microarray hybridization method.

Abstract: The present invention provides a gene-containing composition including a gene and a transporter, the transporter being capable of transporting the gene from a pregnant body to fetal cells. When this composition is administered to a pregnant body, birth of offsprings with gene deficiency can be prevented, and gene deficiency can be treated during pregnancy. In animal experiments, when an unknown gene is introduced to animals during their embryogenic stage, the function of the gene in ontogenesis can be elucidated. Moreover, the composition can be used for breeding animals such as pets, industrial animals and cattle.

Abstract: The present invention provides a gene-containing composition including a gene and a transporter, the transporter being capable of transporting the gene from a pregnant body to fetal cells. When this composition is administered to a pregnant body, birth of offsprings with gene deficiency can be prevented, and gene deficiency can be treated during pregnancy. In animal experiments, when an unknown gene is introduced to animals during their embryogenic stage, the function of the gene in ontogenesis can be elucidated. Moreover, the composition can be used for breeding animals such as pets, industrial animals and cattle.

Abstract: The present invention provides a polypeptide represented by the following amino acid sequence:(Met)n=X=Leu=Ala=Gly=Glu=Ile=Ala=Gly=Val=Asn - Trp=Glu=Ser - Gly=Tyr=Leu=Val=Gly=Ile=Lys=Arg=Gln=Arg=Arg - Leu=Tyr=Cys=Asn - Val=Gly=Ile=Gly=Phe=His=Leu=Gln=Val=Leu=Pro - Asp=Gly=Arg=Ile - Ser=Gly=Thr=His=Glu=Glu=Asn=Pro=Tyr=Ser=Leu - Leu=Glu=Ile=Ser - Thr=Val=Glu=Arg=Gly=Val=Val=Ser=Leu=Phe=Gly - Val=Arg=Ser=Ala - Leu=Phe=Val=Ala=Met=Asn=Ser=Lys=Gly=Arg=Leu - Tyr=Ala=Thr=Pro - Ser=Phe=Gin=Glu=Glu=Cys=Lys=Phe=Arg=Glu=Thr Leu=Leu=Pro=Asn - Asn=Tyr=Asn=Ala=Tyr=Glu=Ser=Asp=Leu=Tyr=Gln - Gly=Thr=Tyr=Ile - Ala=Leu=Ser=Lys=Tyr=Gly=Arg=Val=Lys=Arg=Gly - Ser=Lys=Val=Ser - Pro=Ile=Met=Thr=Val=Thr=His=Phe=Leu=Pro=Arg=Ile wherein n is 0 or 1 and X represents Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly or a fragment thereof (n=0: SEQ ID NO: 1, n=1: SEQ ID NO: 2), a recombinant DNA coding for the polypeptide, a vector containing the recombinant DNA, the preparation of a

Abstract: A hydraulic excavator includes a revolving upper structure having a rear half swingable within the width of the machine. The revolving upper structure has a front portion on which a cab is disposed. An internal combustion engine is mounted in the rear of the cab. Various components including a direction control valve, a hydraulic oil tank, and a fuel tank are mounted alongside the cab. The revolving upper structure has a front end portion supporting thereon a bracket, and a boom pivotally mounted on the bracket for undertaking a swing motion within an angular range of an angle less than 180.degree.. The swing angle is so set as to extend over a greater extent on one side located close to the cab than on the other side remote from the cab. The revolving upper structure further includes a projecting portion swelling out into an area kept out of the swing range of the boom.

Abstract: The present invention provides a polypeptide represented by the following amino acid sequence: ##STR1## wherein n is 0 or 1 and X represents Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly or a fragment thereof (n=0: SEQ ID NO:1, n=1: SEQ ID NO:2), a recombinant DNA coding for the polypeptide, a vector containing the recombinant DNA, the preparation of a transformant carrying the vector, and the production of the polypeptide with the transformant. The use of this peptide in pharmaceutical compositions is also provided.

Abstract: A deletion type mutein of heparin-binding secretory transforming factor (hst-1) possesses excellent cell growth promoting activity and is stable. The present mutein can therefore be used as a therapeutic medicine such as a healing promoter for burns, wounds, surgical injuries etc.

Abstract: A flexible sheath for an endoscope has a flexible hollow cylindrical tube and a helical coil spring which is inserted into the flexible hollow cylindrical tube. One end of the spring is made engageable with one end of the hollow cylindrical tube to adjust the flexibility of the flexible sheath. A mechanism for compressing the helical coil spring is provided at the other end of the hollow cylindrical tube. The mechanism comprises a spring-compressing member disposed at the other end of the helical coil spring and an actuating member for reciprocating the spring-compressing member between a position in which the spring-compressing member compresses the helical coil spring and a position in which the spring-compressing member is axially removed from the other end of the helical coil spring.

Abstract: A photographing apparatus for an endoscope, which comprises an endoscope body (10) including an obervational optical system (12.sub.1) and a fiber light guide (14), a light source unit (46) including a light source section (21) for providing light to the fiber light guide (14) and a camera (32) mounted on a light path, through which an optical image led out through the observational optical system (12.sub.1) proceeds.The camera (32) includes a photoelectric converter (34) disposed on the afore-mentioned light path of the optical image for producing a brightness signal (E10) corresponding to the brightness of said optical image and a transmitter (36) receiving the brightness signal (E10) from the photoelectric converter (34) and producing a transmission signal (E20) corresponding to the brightness signal (E10).