Patents by Inventor Masaaki Watanuki

Masaaki Watanuki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ?-amylase activity inhibitors
    Patent number: 7037536
    Abstract: The present invention relates to an ?-amylase activity inhibitor, and to food and beverages comprising the ?-amylase activity inhibitor. The ?-amylase activity inhibitor of the present invention exhibits remarkably excellent ?-amylase inhibitory activity as compared with guava extract. Accordingly, food and beverages containing the ?-amylase activity inhibitor are diet food and beverages suitable for people of high blood-sugar level or hyderlipidemia.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: May 2, 2006
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Takashi Makino, Ritsuo Aiyama, Yoriko Deguchi, Masaaki Watanuki, Masako Nakazawa, Harumi Mizukoshi, Masato Nagaoka, Katsuhisa Harada, Kuniko Osada
  • Alpha-amylase activity inhibitors
    Publication number: 20030124208
    Abstract: The present invention relates to an &agr;-amylase activity inhibitor containing, as an effective component, polyphenols obtained through the following process: guava leaves and/or guava fruit are subjected to extraction with one or more solvents selected from among water and hydrophilic solvents; the resultant extract is subjected to ultrafiltration, to thereby remove substances having a molecular weight of less than 5,000; the remaining fraction is subjected to the butyl support hydrophobic chromatography. The elution (flow rate: 1 mL/min) of the sample was accomplished with the pH gradient by use of sodium dihydrogenphosphate and sodium phosphate solution (0.02 mol/L) and a fraction of the eluted substance is recovered, which fraction corresponds to the third single peak of an elution curve which is obtained when the absorbance of the substance is measured at 260 nm.
    Type: Application
    Filed: November 14, 2002
    Publication date: July 3, 2003
    Inventors: Takashi Makino, Ritsuo Aiyama, Yoriko Deguchi, Masaaki Watanuki, Masako Nakazawa, Harumi Mizukoshi, Masato Nagaoka, Katsuhisa Harada, Kuniko Osada
  • Antihypertensives containing polysaccharide peptidoglycan complexes extracted from the cell wall of lactic acid bacteria
    Patent number: 5234904
    Abstract: The present invention relates to antihypertensives and food and drinks, containing as effective component polysaccharideglycopeptide complexes derived from cell wall of Gram positive bacteria (also referred to as peptidoglycan). The present invention provides extremely strong and safe antihypertensives and food and drinks, which may exert hypotensive effects if administered orally to spontaneous hypertensive rats and renal hypertensive rats at a single dose as low as 1 mg/kg.
    Type: Grant
    Filed: June 22, 1990
    Date of Patent: August 10, 1993
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Haruji Sawada, Masayoshi Furusiro, Kouichi Hirai, Mahoko Motoike, Tunekazu Watanabe, Teruo Yokokura, Masaaki Watanuki, Seizaburo Kobayashi
  • Method for producing conjugated ursodeoxycholic acids by means of microbial transformation
    Patent number: 4604353
    Abstract: A one step method of producing conjugated ursodeoxycholic acids from conjugated lithocholic acids by means of microbial transformation which comprises subjecting the conjugated lithocholic acids to the action of microorganisms which belong to Mortierella and which are capable of producing conjugated ursodeoxycholic acids from conjugated lithocholic acids.
    Type: Grant
    Filed: February 24, 1984
    Date of Patent: August 5, 1986
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Haruji Sawada, Masaaki Watanuki