Patents by Inventor Masabumi Takahashi

Masabumi Takahashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing 5-(difluoromethyl)pyrazine-2-carboxylic acid and production intermediate thereof
    Patent number: 9227942
    Abstract: 5-(Difluoromethyl)pyrazine-2-carboxylic acid, which is a raw material for the construction of 5-(difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an A? production inhibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5-[carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: January 5, 2016
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Kazuhiro Yoshizawa, Masayuki Omori, Yuzo Watanabe, Mitsuo Nagai, Masabumi Takahashi, Francis G. Fang
  • METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF
    Publication number: 20150087836
    Abstract: 5-(Difluoromethyl)pyrazine-2-carboxilic acid, which is a raw material for the construction of 5-(difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an A production inhibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5-[carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate.
    Type: Application
    Filed: April 25, 2013
    Publication date: March 26, 2015
    Inventors: Kazuhiro Yoshizawa, Masayuki Omori, Yuzo Watanabe, Mitsuo Nagai, Masabumi Takahashi, Francis G. Fang
  • Method for producing phenoxypyridine derivative
    Patent number: 8759530
    Abstract: A method for producing a compound or a salt thereof represented by a formula (I), comprising reacting a compound or a salt thereof represented by a formula (II) and an aniline derivative represented by a formula (III) in water or a mixed solvent of water and an organic solvent in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and substantially in the absence of a base is disclosed, wherein R1 is a 4-[3-(dimethylamino)azetidin-1-yl]piperidin-1-yl group, a 4-(4-methylpiperazin-1-yl)piperidin-1-yl group, a 3-hydroxyazetidin-1-yl group or a methyl(1-methylpiperidin-4-yl)amino group, R2, R3, R4 and R5 may be the same or different and are each a hydrogen atom or a fluorine atom, and R6 is a hydrogen atom or a halogen atom.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: June 24, 2014
    Assignee: Eisai R&D Management Co., Ltd.
    Inventor: Masabumi Takahashi
  • Method for Producing Phenoxypyridine Derivative
    Publication number: 20140011999
    Abstract: A method for producing a compound or a salt thereof represented by a formula (I), comprising reacting a compound or a salt thereof represented by a formula (II) and an aniline derivative represented by a formula (III) in water or a mixed solvent of water and an organic solvent in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and substantially in the absence of a base is disclosed, wherein R1 is a 4-[3-(dimethylamino)azetidin-1-yl]piperidin-1-yl group, a 4-(4-methylpiperazin-1-yl)piperidin-1-yl group, a 3-hydroxyazetidin-1-yl group or a methyl(1-methylpiperidin-4-yl)amino group, R2, R3, R4 and R5 may be the same or different and are each a hydrogen atom or a fluorine atom, and R6 is a hydrogen atom or a halogen atom.
    Type: Application
    Filed: March 27, 2012
    Publication date: January 9, 2014
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventor: Masabumi Takahashi