Abstract: The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to die cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82nd to the 92nd nucleotide from the 5? end of exon 5 of the G6PC gene with c.648C>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).

Abstract: A display apparatus includes: a display; a display driver that drives the display such that the display displays in accordance with display data; and a host controller that transfers update display data of one screen to the display driver. The display driver includes a light-emission controller that causes a self-luminous elements to emit light, and a memory that stores the update display data of the one screen. The display driver reads the update display data on the memory after an elapse of a predetermined period of time from a drive end time at which the display controller finishes driving in accordance with the update display data and drives the screen by using the read update display data. The display driver drives the self-luminous elements once or more at a timing when the update display data from the host controller to the display driver is not updated.

Abstract: A display apparatus includes: a display; a display driver that drives the display such that the display displays in accordance with display data; and a host controller that transfers update display data of one screen to the display driver. The display driver includes a light-emission controller that causes a self-luminous elements to emit light, and a memory that stores the update display data of the one screen. The display driver reads the update display data on the memory after an elapse of a predetermined period of time from a drive end time at which the display controller finishes driving in accordance with the update display data and drives the screen by using the read update display data. The display driver drives the self-luminous elements once or more at a timing when the update display data from the host controller to the display driver is not updated.

Abstract: An audio mixer includes an operation panel having a plurality of faders, a display device, and a first surface, a second surface, and a third surface, the second surface extending from the first surface and the third surface extending from the second surface, in a front-back direction. The plurality of faders are disposed along the first surface and arranged in a left-right direction. The display device is disposed along the third surface. A first reference distance from a common reference point to a first point of the first surface is equal to greater than a second reference distance from the common reference point to a second point of the third surface. The first point is disposed at a frontmost portion of the operation panel. The second point is disposed higher than the first point, at an uppermost portion of the third surface. The common reference position is disposed higher than the second point.

Abstract: A display apparatus includes: a display; a display driver that drives the display such that the display displays in accordance with display data; and a host controller that transfers update display data of one screen to the display driver. The display driver includes a light-emission controller that causes a self-luminous elements to emit light, and a memory that stores the update display data of the one screen. The display driver reads the update display data on the memory after an elapse of a predetermined period of time from a drive end time at which the display controller finishes driving in accordance with the update display data and drives the screen by using the read update display data. The display driver drives the self-luminous elements once or more at a timing when the update display data from the host controller to the display driver is not updated.

Abstract: A display apparatus includes: a display; a display driver that drives the display such that the display displays in accordance with display data; and a host controller that transfers update display data of one screen to the display driver. The display driver includes a light-emission controller that causes a self-luminous elements to emit light, and a memory that stores the update display data of the one screen. The display driver reads the update display data on the memory after an elapse of a predetermined period of time from a drive end time at which the display controller finishes driving in accordance with the update display data and drives the screen by using the read update display data. The display driver drives the self-luminous elements once or more at a timing when the update display data from the host controller to the display driver is not updated.

Abstract: The present invention relates to a method of assisting the diagnosis of metastatic castration resistant prostate cancer, including measuring an amount of an extracellular vesicle having phosphatidylserine and a prostate specific membrane antigen in a biological specimen derived from a subject; and determining whether or not the subject has metastatic castration resistant prostate cancer by using, as an indicator, the amount of the extracellular vesicle having phosphatidylserine and a prostate specific membrane antigen.

Abstract: A display device includes: a display unit; a display driver configured to drive the display unit; and a display-data generator configured to transfer a screenful of update display data to the display driver. The display driver includes a light-emission controller configured to control self-luminous elements to emit light, and a memory storing a screenful of the update display data. After a lapse of a predetermined time period from a driving stop time, the display driver reads the update display data stored in the memory and then uses the update display data to drive a screen, the driving stop time being a time when the display unit is stopped from driving based on the update display data. The display driver causes the self-luminous elements of the display unit to emit light, even during a display update or no display update performed on the display driver by the display-data generator.

Abstract: A control apparatus configured to control a display apparatus including a self-luminous element includes: an image judgment unit configured to determine whether or not a ratio of a number of pixels located in a predetermined area of an image and having gradation levels within a gradation range from a first gradation level not equal to a lowest gradation level to a second gradation level not equal to a highest gradation level is equal to or larger than a threshold value; and a drive change unit configured to determine a refresh rate of the display apparatus including the self-luminous element according to a result of the determination made by the image judgment unit. The image judgment unit is configured to determine at least one of (1) the value of the first gradation level and the value of the second gradation level, and (2) the threshold value.

Abstract: A display device includes: a display unit; a display driver configured to drive the display unit; and a display-data generator configured to transfer a screenful of update display data to the display driver. The display driver includes a light-emission controller configured to control self-luminous elements to emit light, and a memory storing a screenful of the update display data. After a lapse of a predetermined time period from a driving stop time, the display driver reads the update display data stored in the memory and then uses the update display data to drive a screen, the driving stop time being a time when the display unit is stopped from driving based on the update display data. The display driver causes the self-luminous elements of the display unit to emit light, even during a display update or no display update performed on the display driver by the display-data generator.

Abstract: A display apparatus includes: a display; a display driver that drives the display such that the display displays in accordance with display data; and a host controller that transfers update display data of one screen to the display driver. The display driver includes a light-emission controller that causes a self-luminous elements to emit light, and a memory that stores the update display data of the one screen. The display driver reads the update display data on the memory after an elapse of a predetermined period of time from a drive end time at which the display controller finishes driving in accordance with the update display data and drives the screen by using the read update display data. The display driver drives the self-luminous elements once or more at a timing when the update display data from the host controller to the display driver is not updated.

Abstract: An outermost end of a carcass folded-up portion is located in a tire width direction inside than an end in the tire width direction of the outermost inclined belt layer, in the tire radial direction between a carcass main body portion and the innermost inclined belt layer. A carcass cord in the folded-up portion located on the outermost side of the tire and a belt cord of the outermost inclined belt layer cross each other to be inclined in the same direction in a tire circumferential direction as being from one side toward the other side in the tire width direction, a difference in inclination angle is 30° or less, a width of the outermost inclined belt layer is larger than that of the innermost inclined belt layer, and in-plane rigidity per unit width of the innermost inclined belt layer is higher than that of the outermost inclined belt layer.

Abstract: An audio mixer includes an operation panel having a plurality of faders, a display device, and a first surface, a second surface, and a third surface, the second surface extending from the first surface and the third surface extending from the second surface, in a front-back direction. The plurality of faders are disposed along the first surface and arranged in a left-right direction. The display device is disposed along the third surface. A first reference distance from a common reference point to a first point of the first surface is equal to greater than a second reference distance from the common reference point to a second point of the third surface. The first point is disposed at a frontmost portion of the operation panel. The second point is disposed higher than the first point, at an uppermost portion of the third surface. The common reference position is disposed higher than the second point.

Abstract: A display apparatus comprises a light-transmitting cover that transmits light; a display panel including at least a polarizer and a plurality of layers, the plurality of layers including a display layer, the polarizer having an opening through. which incoming light from the light-transmitting cover is allowed to pass into an imaging device, the imaging device being positioned opposite to the light-transmitting cover with respect to the display panel; and a filler that fills the opening, and transmits the incoming light.

Abstract: This tire improves high traction performance over an extended period of time and/or improves control performance while maintaining traction performance. This tire includes a tread with blocks formed thereon, protrusions (11, 21, 31) extending outward in the tire radial direction and formed on more than one of the blocks, and stepped portions (12, 22) and/or a second concavity (24) formed on a side of the protrusions (11, 21, 31).

Abstract: A display panel that displays an image and a cover panel that is superposed onto a front surface of the display panel and protects the display panel are included. An opening is formed in at least part of the cover panel, a device by which input or output of predetermined information is performed is provided in the opening, and black display is performed in an area of the display panel, which faces the device.

Abstract: A brushless motor device configured to: determine a first upper limit of a current value which flows through a coil when a rotation speed of a rotor is accelerated from a first speed to a second speed, wherein, in a case where the current value of the first upper limit flows through the coil when the rotor is rotated at the second speed, a first time period, which is from a start of a non-energization time period of the coil until an induced voltage reaches a threshold value, is longer than a second time period, which is from the start of the non-energization time period until a counter-electromotive voltage becomes zero; and change switching of each switching element of an inverter circuit by using a second upper limit greater than the first upper limit and the first upper limit.