Abstract: Pharmaceutical composition of certain dihydropyridine compounds and salts thereof are provided which exhibit both Ca.sup.2+ -antagonistic and adrenergic beta-receptor blocking activities and therefore are useful for the treatment of ischemic heart diseases and hypertension. The pharmaceutical compositions contains either 4-(2-hydroxy-3-phenoxy-propylamino)-butyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate or 6-(2-hydroxy-3-phenoxypropylamino) hexyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate or their pharmaceutically acceptable salts.

Abstract: Novel benzoxazine derivatives of the formula (I): ##STR1## are provided as well as their pharmaceutically acceptable salts and a method for their use as potassium channel activating agents 2-(3,4-Dihydro-2, 2-dimethyl-6-phenylsulfonyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide is illustrative of a benzoxazine derivative of formula (I).

Abstract: Dihydropyridine compounds and salts thereof are provided which exhibit both Ca.sup.2+ -antagonistic and adrenergic beta-receptor blocking activities and therefore are useful for the treatment of ischemic heart diseases and hypertension. The compounds have the formula ##STR1## wherein A represents a straight or branched carbon chain alkylene group having 1 to 10 carbon atoms which may be interrupted by an oxygen atom(s); R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group; R.sup.2 represents an amino group, ##STR2## R.sup.3 represents a straight or branched carbon chain alkyl group having 1 to 10 carbon atoms which may be interrupted by an oxygen atom(s), or ##STR3## R.sup.5 and R.sup.6, which may be the same or different, each represents a hydrogen atom, a nitro group, a halogen atom, a trifluoromethyl group, a cyano group, a lower alkyl group, a lower alkoxy group or a lower alkenyloxy group; R.sup.

Abstract: Therapeutic agents for ischemic heart diseases are provided and contain as an effective component a glutathione monoalkyl ester. The invention is also directed to the use of such therapeutic agents for the treatment of ischemic heart diseases.

Abstract: A slow-release composite having pyroglutamyl-histidyl-triptophyl-seryl- tyrosyl-D-leucyl-leucyl-arginyl-proline ethylamide or a salt thereof encapsulated in a polymer matrix and a process the same are herein disclosed.

Abstract: A dihydropyridine compound of the following general formula (I) or a salt thereof: ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, each represents a C.sub.1 to C.sub.10 alkyl group, a lower alkyl group which is interrupted by oxygen atom(s), or a lower alkyl group substituted by C.sub.3 to C.sub.6 alicyclic group(s); R.sup.3 and R.sup.4, which are the same or different, each represents a lower alkyl group; R.sup.5 and R.sup.6, which are the same or different, each represents a hydrogen atom, a nitro group, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower alkylsulfonyl group, or a lower alkylsulfinyl group; R.sup.7 and R.sup.8, which are the same or different, each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkoxy group, or a lower alkanoylamino group, or R.sup.7 may combine with R.sup.8 to form a naphthyl group together with the adjacent phenyl group; A represents a single bond, a vinylene group (--CH.dbd.

Abstract: A measurement device for measuring a physical property such as temperature difference, displacement, pressure, fluid flow rate, etc.

Abstract: A system and method for controlling an ignition timing of an internal combustion engine. In the system, an accumulated value of a deviation or a value corelative to the accumulated value is calculated as an error amount whenever the deviation between a crank angle value at a time when pressure in a combustion chamber has reached its maximum and a target value thereof, whether the error amount exceeds a predetermined allowable limit value is determined whether the error amount is calculated, a corrective amount of ignition timing is calculated when the error amount exceeds the predetermined allowable limit value. Consequently, the correction of ignition timing can be carried out in a quick response during the ransient driving state of engine and engine drivability can be improved.

Abstract: A slow-release composite having pyroglutamyl-histidyl-triptophyl-seryl-tyrosyl-D-leucyl-leucyl-arginyl-pro line ethylamide or a salt thereof encapsulated in a polymer matrix and a process the same are herein disclosed.

Abstract: A device and method for measuring a temperature difference at different positions which cancels offset voltages produced by a temperature sensitive element, e.g., a thermocouple used in the device and the device itself.

Abstract: An Estracyt compound having a carcinostatic bound thereto is obtained by reacting an Estracyt compound with a carcinostatic having one or more radicals selected from among COOH, Cl, NH.sub.2 and OH, either directly or after reaction with an amine to replace one or both Cl groups in the nitrogen mustard portion in the Estracyt compound with a NH.sub.2 group, in the presence or absence of a catalyst. The resulting compound is more effective in cancer control than the Estracyt compound associated substance.

Abstract: A process is, herein disclosed, for producing a slow release composite having a physiologically active substance encapsulated therein, which comprises preparing a system wherein one or more physiologically active substances are in contact with protein from one or more protein sources, and bringing said system into direct contact with steam at temperatures between 50.degree. C. and 100.degree. C. to denature the protein and make the same hydrophobic, to thereby make a slow release composite having the physiologically active substance dispersed, fixed and encapsulated therein.

Abstract: A failsafe system for an engine-control servomotor compares a servomotor command signal to a feedback signal from the servomotor. When the magnitude of the difference between the two signals is greater than a predetermined value for a predetermined time, the failsafe system shuts down the servomotor or performs some other engine shut-down procedure. The failsafe system includes a comparator for comparing the two signals, the output of which leads to two other op-amp-type comparators connected in parallel, which work on negative or positive outputs of the first-mentioned comparator, respectively. Each of the later comparators receives a reference voltage input against which to compare the output of the first-mentioned comparator. Their outputs lead parallelly to time-delay circuits which check for a positive output for a predetermined length of time by a well-known capacitor-integration technique.

Abstract: A fuel injection means for an internal combustion engine of an automobile is disclosed which comprises a pulse length determination circuit which receives a driving condition signal and develops a signal of a pulse length corresponding to the driving condition, a fuel injection starting signal generator circuit which develops a fuel injection starting signal and a driving signal generator circuit which develops a driving signal of a pulse length corresponding to that of the signal from the pulse length determination circuit. The driving signal thus developed is sent to a fuel injection valve, thereby fuel of a reliably controlled quantity is injected with a reliably controlled timing not only during usual driving condition but also during acceleration.

Abstract: A process is herein disclosed for producing a slow release composite comprising grinding and mixing mechanically in a frozen state one or more polypeptides, one or more proteins and one or more physiologically active substances shaping the blend into a desired form and compressing at a pressure of from 100 to 20,000 kg/cm.sup.2 to thereby produce a slow release composite having the physiologically active substances encapsulated therein.

Abstract: An output signal of a vibration sensor mounted on an internal combustion engine is compared with a background noise reference signal to produce a knock signal which can accurately represent the intensity of knocking. The background noise level signal is produced by averaging a component of the vibration sensor output signal which represents the vibration of the engine other than knock-induced vibration. In order to produce a feedback signal for inhibiting the knock induced component of the sensor output signal, a first comparator compares the sensor output signal with a first reference signal having a sufficiently low level. Knock signal is produced by a second comparator which receives a second reference signal, which is proportional to the first reference signal but having sufficiently higher level, thereby enabling a precise determination of knock intensity.

Abstract: A first circuit is provided for producing an output which changes at a certain rate by an amount corresponding to a predetermined crank angle in the direction of retarding a spark timing each time a knocking determination signal, representing that knocking occurs, is inputted thereto with a frequency higher than a predetermined frequency and an amplitude larger than a predetermined amplitude. The output from the first circuit further changes at a smaller rate than said certain rate in the direction of advancing the spark timing in the absence of the knocking determination signal. A second circuit is provided for outputting a waveform which is reset each time a spark command signal is inputted thereto and which thereafter changes to a predetermined level at a rate depending upon the rotational speed of the engine. A third circuit is provided for comparing the outputs of the first and second circuits to output a pulse signal of a duration depending upon the level of the output of the first circuit.

Abstract: The calculation of an adjustment value, which is determined by the concentration of oxygen in the exhaust gas, the opening of a throttle valve provided in an intake air passage to the engine, the engine temperature, etc., is started every time a predetermined number of repeatedly produced start signals, the repetition rate of which corresponds to the rotational speed of the crankshaft, occur. A basic value for fuel supply, T.sub.p =k Q/N, is calculated from the engine operating parameters; the amount of flow of intake air into the engine, Q the rotational speed of the crankshaft, N, and a constant k, and adjusted according to the adjustment value to obtain a control output signal, in the vicinity of the next start signal after said predetermined number.

Abstract: Disclosed is an air/fuel control system for an internal combustion engine which selectively carries out open loop control and feedback control in which the air/fuel ratio is controlled based on the sensed concentration of an exhaust gas component. The system has a means for generating a variable reference signal corresponding to an exhaust gas sensor output and a means for measuring a period after the air-fuel mixture becomes rich and for generating a signal for switching control operation from feedback control to open loop control. The latter means clears the measured period responsive to interrupting feedback control after the expiration of a given period. This effectively prevents control operation from switching too frequently between feedback control and open loop control.

Abstract: An engine controlling device includes an operating circuit (3) supplied with output signal of a knocking sensor (1) to generate a control signal which is used to effect an optimum control of at least one of ignition timing, exhaust gas recirculation flow rate, fuel injection quantity and fuel injection timing, to optimize combustion state of the engine. The device is further provided with an acceleration detector (5) whose output signal is supplied to the operating circuit (3) to generate a forced control signal during the accelerating condition of the engine regardless of the control signal derived from the knocking sensor (1). The forced control signal is used to control at least one of the above-mentioned control variables, and eliminates adverse influence of delay time in the control device to enable optimization of the combustion state even during a sudden acceleration.