Abstract: The present invention provides a method for selecting a cancer patient for whom a combination therapy with a retinoid and a cancer treatment agent is effective, which comprises a step of selecting a cancer patient having a malignant tumor with the infiltration of cancer-associated fibroblasts in the stroma. In addition, the present invention provides a medicament which comprises a cancer patient having a malignant tumor with the infiltration of cancer-associated fibroblasts in the stroma is a subject and is administered in combination of a retinoid and a cancer therapeutic agent.

Abstract: An anti-MEFLIN antibody and a pharmaceutical composition comprising the antibody is described. The pharmaceutical composition may comprise an antibody-drug conjugate (ADC) of the anti-MEFLIN antibody and a cytotoxic agent, which may be connected to each other by a linker. The pharmaceutical composition may be used in the treatment of a cancer in a subject.

Abstract: An object of the present invention is to provide a novel marker that can be used to predict the effect of anti-PD-1 antibody/anti-PD-L1 antibody therapy with high sensitivity, and use thereof. Provided is a biomarker for predicting the effect of anti-PD-1 antibody/anti-PD-L1 antibody therapy, including an immunoglobulin superfamily containing leucine-rich repeat (ISLR).

Abstract: Provided are a knockout mouse, a method for screening a substance for suppressing mesial temporal lobe epilepsy, and a method for selecting a technique for suppressing mesial temporal lobe epilepsy. A knockout mouse 30 or more days of age that has lost the function of the Girdin gene in at least the nervous tissues and exhibits the phenotypes of (1), (2), and (3) below. (1) hippocampal sclerosis should be present, (2) extrahippocampal brain damage should be limited, and (3) spontaneous epilepsy that can be said to be of hippocampal origin should be present.

Abstract: Provided are a knockout mouse, a method for screening a substance for suppressing mesial temporal lobe epilepsy, and a method for selecting a technique for suppressing mesial temporal lobe epilepsy. A knockout mouse 30 or more days of age that has lost the function of the Girdin gene in at least the nervous tissues and exhibits the phenotypes of (1), (2), and (3) below. (1) hippocampal sclerosis should be present, (2) extrahippocampal brain damage should be limited, and (3) spontaneous epilepsy that can be said to be of hippocampal origin should be present.

Abstract: Provided is an embedding medium for specimen preparation that, when preparing a curable base material nonpenetrating specimen, involves no thermal invasion of the tissue, minimizes wrinkling and tearing during thin slicing, and makes it possible to confirm the position of the tissue in the embedding medium, and also for preparing a curable base material penetrating specimen on the same plane as a curable base material nonpenetrating specimen. The problem can be solved by using an embedding medium for specimen preparation that includes gelatin that is in a liquid state at 15° C.-25° C. and assumes a solid state at 4° C. when made into an aqueous solution.

Abstract: A wireless communication network system including: mobile radios mounted on a moving body moving along a predetermined route; and a plurality of immobile radios arranged along the route, adjacent immobile radios wirelessly communicating with each other, to transmit information from a transmission source to a terminal by relaying the information. The mobile radios and the immobile radios communicate with each other by a time division multiple access method, in which time synchronization is performed to allow each of the mobile radios and the immobile radios to communicate in an allocated time slot. The mobile radios are disposed on front and rear parts of the moving body and are capable of communicating with each other. When the moving body is between the immobile radios arranged to be capable of wirelessly communicating with each other, the two mobile radios is capable of relaying information propagation between the immobile radios.

Abstract: Antibodies are provided that specifically bind to Acting Binding Protein Girdin (Akt Phosphorylation Enhancer), a new substrate of serine/threonine kinase. Additionally, methods of making hybridomas for producing said antibodies and methods of detecting girdin using said antibodies are provided herein. The antibodies and methods are useful for detecting girdin in tissue samples, such as tissue samples from subjects having or suspected of having a disorder in which any of cell motility, cell movement, and angiogenesis is involved.

Abstract: It is intended to identity a protein involved in a molecular mechanism between Akt and cell motility as well as to elucidate its function and find its application. In the present teachings, for achieving the above object, protein or partial peptide thereof containing an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID: 2 is utilized in the screening of a compound or a salt thereof that activates or inhibits any of cell motility, cell migration and angiogenesis.

Abstract: A ground device 1 transmits train control information to an on-board device mounted on a train. The ground device 1 receives a train detection signal (TD signal) from a train with an ATC/TD on-board device mounted thereon through loop coils 21 to 2m, and receives a train position signal from a train with a CBTC on-board device mounted thereon through wayside radio sets 61 to 6n. Based on the input train detection signal and train position signal, the ground device 1 detects the position of each train traveling on a route R, generates control information on each train based on the detected position of each train, and converts the control information to an ATC signal and a CBTC signal. The ATC signal is transmitted to the loop coils 21 to 2m through information transmission units 4, and the CBTC signal is transmitted through the wayside radio sets 61 to 6n.

Abstract: An on-board device capable of receiving train control signals from ground-side equipment of train control systems of different types or the like to control the speed of a train and the like appropriately, is provided. An on-board device 10 mounted on a train 1 includes ATC/TD antennas 11a, 11b that receive an ATC signal including train control information from loop coils installed along a route of the train 1, a vehicle radio set 12 that receives a CBTC signal including train control information from wayside radio sets installed along the route, an ATC control unit 141 that controls the train 1 based on the train control information in the ATC signal, a CBTC control unit 142 that controls the train 1 based on the train control information in the CBTC signal, and a selection unit 143 that selects the ATC control unit 141 or the CBTC control unit 142.

Abstract: Disclosed is a means for improving the clinical outcomes of cancer therapy. Specifically disclosed is an activity potentiator comprising a compound capable of inhibiting the expression of RFP (RET finger protein) gene or the activity of RFP as an active ingredient. The activity of an anti-cancer agent having an oxidative stress inducing ability can be potentiated by using the anti-cancer agent in combination with the activity potentiator. Further specifically disclosed are a biomarker useful for the recognition of prognosis in a cancer patient and use of the biomarker.

Abstract: An on-board device capable of receiving train control signals from ground-side equipment of train control systems of different types or the like to control the speed of a train and the like appropriately, is provided. An on-board device 10 mounted on a train 1 includes ATC/TD antennas 11a, 11b that receive an ATC signal including train control information from loop coils installed along a route of the train 1, a vehicle radio set 12 that receives a CBTC signal including train control information from wayside radio sets installed along the route, an ATC control unit 141 that controls the train 1 based on the train control information in the ATC signal, a CBTC control unit 142 that controls the train 1 based on the train control information in the CBTC signal, and a selection unit 143 that selects the ATC control unit 141 or the CBTC control unit 142.

Abstract: A ground device 1 transmits train control information to an on-board device mounted on a train. The ground device 1 receives a train detection signal (TD signal) from a train with an ATC/TD on-board device mounted thereon through loop coils 21 to 2m, and receives a train position signal from a train with a CBTC on-board device mounted thereon through wayside radio sets 61 to 6n. Based on the input train detection signal and train position signal, the ground device 1 detects the position of each train traveling on a route R, generates control information on each train based on the detected position of each train, and converts the control information to an ATC signal and a CBTC signal. The ATC signal is transmitted to the loop coils 21 to 2m through information transmission units 4, and the CBTC signal is transmitted through the wayside radio sets 61 to 6n.

Abstract: A wireless communication network system including: mobile radios mounted on a moving body moving along a predetermined route; and a plurality of immobile radios arranged along the route, adjacent immobile radios wirelessly communicating with each other, to transmit information from a transmission source to a terminal by relaying the information. The mobile radios and the immobile radios communicate with each other by a time division multiple access method, in which time synchronization is performed to allow each of the mobile radios and the immobile radios to communicate in an allocated time slot. The mobile radios are disposed on front and rear parts of the moving body and are capable of communicating with each other. When the moving body is between the immobile radios arranged to be capable of wirelessly communicating with each other, the two mobile radios is capable of relaying information propagation between the immobile radios.

Abstract: A honeycomb carrier for an exhaust gas-cleaning catalyst to clean e.g. an exhaust gas of an automobile particularly containing NOx, wherein the material for the honeycomb carrier is an aluminum magnesium titanate sintered product obtained by firing at from 1,000 to 1,700° C. a molded product formed from a raw material mixture comprising 100 parts by mass, as calculated as oxides, of a mixture comprising a Mg-containing compound, an Al-containing compound and a Ti-containing compound in the same metal component ratio as the metal component ratio of Mg, Al and Ti in an aluminum magnesium titanate represented by the empirical formula MgxAl2(1+x)Ti(1+x)O5 (wherein 0?x?1), and from 1 to 10 parts by mass of an alkali feldspar represented by the empirical formula (NayK1?y)AlSi3O8 (wherein 0?y?1).

Abstract: To provide an aluminum magnesium titanate crystal structure which can be used stably in variable high temperatures, because of its excellent heat resistance, thermal shock resistance, high thermal decomposition resistance and high mechanical property, and a process for its production. An aluminum magnesium titanate crystal structure, which is a solid solution wherein at least some of Al atoms in the surface layer of aluminum magnesium titanate crystal represented by the empirical formula MgxAl2(1?x)Ti(1+x)O5 (wherein 0.1?x<1) are substituted with Si atoms, and which has a thermal expansion coefficient of from ?6×10?6 (1/K) to 6×10?6 (1/K) in a range of from 50 to 800° C. at a temperature raising rate of 20° C./min, and a remaining ratio of aluminum magnesium titanate of at least 50%, when held in an atmosphere of 1,100° C. for 300 hours.

Abstract: To provide an aluminum magnesium titanate crystal structure which can be used stably in variable high temperatures, because of its excellent heat resistance, thermal shock resistance, high thermal decomposition resistance and high mechanical property, and a process for its production. An aluminum magnesium titanate crystal structure, which is a solid solution wherein at least some of Al atoms in the surface layer of aluminum magnesium titanate crystal represented by the empirical formula MgxAl2(1?x)Ti(1+x)O5 (wherein 0.1?x<1) are substituted with Si atoms, and which has a thermal expansion coefficient of from ?6×10?6(1/K) to 6×10?6(1/K) in a range of from 50 to 800° C. at a temperature raising rate of 20° C./min, and a remaining ratio of aluminum magnesium titanate of at least 50%, when held in an atmosphere of 1,100° C. for 300 hours.

Abstract: Disclosed is a means for improving the clinical outcomes of cancer therapy. Specifically disclosed is an activity potentiator comprising a compound capable of inhibiting the expression of RFP (RET finger protein) gene or the activity of RFP as an active ingredient. The activity of an anti-cancer agent having an oxidative stress inducing ability can be potentiated by using the anti-cancer agent in combination with the activity potentiator. Further specifically disclosed are a biomarker useful for the recognition of prognosis in a cancer patient and use of the biomarker.

Abstract: A molded oxide product of the present invention contains an oxide region and an organic cross-linked region and has at least a surface layer formed of an inorganic glassy material. The molded oxide product can combine both organic and inorganic advantages such as good workability of organic materials and high weather resistance, heat resistance and hardness of inorganic materials. The molded oxide product can be produced through the following steps: step A for preparing a precursor R2-M-O-M? having a polymerizable functional group-containing organic group R2 and a M-O-M? bond; step B for applying an application liquid containing the precursor; step C for hardening the application liquid by photocuring and/or thermosetting; and step D for performing oxidation treatment on at least a surface layer of the hardened product in such a manner as to convert at least the surface layer of the hardened product to be of inorganic glassy material.