Abstract: Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same.

Abstract: Disclosed herein are a derivative of a substituted cephalosporanic acid, represented by the formula (I): ##STR1## wherein p is 0, 1 or 2 and R.sup.1 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1; n is 0, 1 or 2 and the carboxyl group may have been converted to the salt or the ester thereof, and an antibiotic comprising a derivative of substituted cephalosporanic acid represented by the formula (I).

Abstract: Polysaccharides having antitumor and other useful pharmacological activities and a process for preparing such polysaccharides are disclosed. These polysaccharides are characterized by .alpha.-bonding of the saccharide component and can be produced from the extracts obtained by the extraction of a basidiomycetous fungus belonging to the genus Coriolus or cultures thereof with an aqueous solvent.

Abstract: A process for preventing the agglomeration of agglomerative powder, such as TEDA monomer piperazine, sodium chloride and ammonium chloride, comprising adding TEDA polymer to the agglomerative powder or adding TEDA to a solution from which the powdery material is crystallized.

Abstract: The present invention relates to a platinum compound having the formula ##STR1## wherein R represents hydrogen atom, an alkali metal atom or a lower alkyl group. The platinum compound is effective as an antitumor and antimicrobial drug.

Abstract: An input/output unit modifiable engine ignition control apparatus for controlling ignition timing for engine cylinders at optimum values based on reference position pulses, crank angle pulses generated and a vacuum signal produced by reference position sensors, a crank angle sensor and a vacuum sensor mounted in an engine. The engine ignition control apparatus is divided into an input-output unit and a control unit. The control unit having a control capacity for an engine having a maximum number of the sensors and engine cylinders, so that the control unit can be shared by a variety of engines for their ignition control simply by changing the input-output unit.

Abstract: A control unit modifiable engine ignition control apparatus for controlling ignition timing optimally for each cylinder by processing reference position pulses, crank angle pulses and a vacuum signal generated by a reference position sensor, a crank angle sensor and a vacuum sensor which are mounted on the engine. The engine ignition control apparatus is divided into an input-output section including an input-output unit and a controller comprising a single or a combination of control units each having a minimum capacity to control a single ignition coil.

Abstract: An engine ignition control circuit includes a crank angle sensor and two reference position sensors. The engine ignition control circuit also includes an ignition timing control unit generating primary ignition signals and a replacement ignition signal generator device. The control circuit further includes a crank angle monitoring circuit which detects the failure of the crank angle sensor and generates a malfunction signal. The malfunction signal controls a data selector which outputs either the primary ignition signals or the replacement ignition signals to drivers and ignition coils for the engine.

Abstract: A suppository base composition comprising 5-80% by weight of polyethylene glycol, 5-80% by weight of triglyceride of fatty acid having 6-22 carbon atoms and 5-80% by weight of a specifically limited alkylene oxide derivative has a melting point of 30.degree.-60.degree. C., a compatibility with both of a polar drug component and a non-polar drug component, and can provide suppositories having excellent moldability and storage stability.

Abstract: An engine ignition system connected between an engine crank and ignition coils includes a reference position signal generating device having reference position sensors, and a crank angle sensing device. The ignition system also includes a signal processing device which receives both the reference position signals and crank angle signals, and when one of the reference position signals is absent continues to generate ignition control signals which activate the ignition coils. The signal processing device includes a counter which counts the crank angle signals and which is reset by the reference position signals, and a decoder which produces a signal when a count value reaches a predetermined count. The signal processing device also includes a logic circuit and a flip-flop for producing either primary ignition control signals or replacement ignition control signals. The replacement ignition control signals are generated when one of the reference position signals is absent.

Abstract: A compound having the general formula (I) is derived from a cephalosporin; ##STR1## wherein R' is a hydrogen atom, an alkyl group having 1 to 4 atoms or an alkali metal and R is --CH.sub.2 COOR', --CH.sub.2 CH.sub.2 SR', ##STR2## or --CH.sub.2 CH.sub.2 COOR' wherein R' is defined above. A pharmaceutical composition containing the compound is excellent in an antibacterial activity, the activity being recovered by the action of an activating enzyme in a living body although the compound per se shows a low activity against the beneficial bacterial colonies in a living body.

Abstract: A compound having the general formula (I) is derived from a cephalosporin; ##STR1## wherein R' is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkali metal.A pharmaceutical composition containing the compound is excellent in an antibacterial activity, the activity being recovered by the action of an activating enzyme in a living body although the compound per se shows a low activity against the beneficial bacterial colonies in a living body.

Abstract: Disclosed is a novel pharmaceutical composition having antitumor (anti-cancer) activity without causing pyrexia and anaphylaxis, formed by an amide bonding between an antibody obtained by the purification of the antibody to tumor (cancer) antigen via affinity-chromatography and an antitumor substance (anti-cancer drug).

Abstract: The present invention relates to a platinum compound having the formula ##STR1## wherein R represents hydrogen atom, an alkali metal atom or a lower alkyl group. The platinum compound is effective as an antitumor and antimicrobial drug.

Abstract: A suppository base composition comprising 5-80% by weight of polyethylene glycol, 5-80% by weight of triglyceride of fatty acid having 6-22 carbon atoms and 5-80% by weight of a specifically limited alkylene oxide derivative has a melting point of 30.degree.-60.degree. C., a compatibility with both of a polar drug component and a non-polar drug component, and can provide suppositories having excellent moldability and storage stability.

Abstract: Disclosed is a novel pharmaceutical composition having antitumor activity without causing pyrexia and anaphylaxis formed by an amido bonding between an antibody obtained by the purification of the antibody to tumor antigen via affinity-chromatography and an antitumor substance.

Abstract: A fungus belonging to genus Coriolus of the class Basidiomycetes is subjected to submerged culture in a liquid medium and the obtained culture is dried and extracted with an aqueous solvent, and then the substances with molecular weights of less than 5,000 are eliminated from the extract solution, whereby a polysaccharide having anti-cancer and other pharmacodynamic effects is obtained in a high yield.