Patents by Inventor Masahiko Fujioka
Masahiko Fujioka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11964939Abstract: An object of the present invention is to provide a novel compound that provides a curing agent that is less likely to volatilize during curing reaction and is excellent in various properties such as heat resistance. As a solution, an aromatic tetracarboxylic acid compound represented by formula (I) below is provided. (In the formula, each R independently represents an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms, and each n independently represents 0 or an integer of 1 to 4.Type: GrantFiled: October 7, 2019Date of Patent: April 23, 2024Assignee: HONSHU CHEMICAL INDUSTRY CO., LTD.Inventors: Rie Fujioka, Masahiko Saibara
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Patent number: 10093670Abstract: Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, —S—, —O—, —NR5—, —C(?O)— or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.Type: GrantFiled: December 27, 2016Date of Patent: October 9, 2018Assignee: SHIONOGI & CO., LTD.Inventors: Eiichi Kojima, Keisuke Tonogaki, Nobuyuki Tanaka, Manabu Katou, Akira Ino, Masafumi Iwatsu, Masahiko Fujioka, Yu Hinata, Naoki Ohyabu
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Publication number: 20170107219Abstract: Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, —S—, —O—, —NR5—, —C(?O)— or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.Type: ApplicationFiled: December 27, 2016Publication date: April 20, 2017Applicant: Shionogi & Co., Ltd.Inventors: Eiichi KOJIMA, Keisuke Tonogaki, Nobuyuki Tanaka, Manabu Katou, Akira Ino, Masafumi Iwatsu, Masahiko Fujioka, Yu Hinata, Naoki Ohyabu
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Patent number: 9567330Abstract: Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, —S—, —O—, —NR5—, —C(?O)— or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.Type: GrantFiled: July 13, 2012Date of Patent: February 14, 2017Assignee: Shionogi & Co., Ltd.Inventors: Eiichi Kojima, Keisuke Tonogaki, Nobuyuki Tanaka, Manabu Katou, Akira Ino, Masafumi Iwatsu, Masahiko Fujioka, Yu Hinata, Naoki Ohyabu
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Patent number: 9440938Abstract: The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.Type: GrantFiled: February 19, 2015Date of Patent: September 13, 2016Assignee: SHIONOGI & CO., LTD.Inventors: Akira Kugimiya, Masahiko Fujioka, Yuki Tachibana, Takami Murashi, Naohiro Onodera
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Patent number: 9133186Abstract: Disclosed is a compound which is useful as an AMPK activator. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein a group represented by the formula: is a group represented by the formula: R1 is each independently halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like; m is an integer of 0 to 3; R2 is hydrogen, or substituted or unsubstituted alkyl; X is —O—; and Y is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.Type: GrantFiled: September 8, 2011Date of Patent: September 15, 2015Assignee: Shionogi & Co., Ltd.Inventors: Keisuke Tonogaki, Akira Ino, Eiichi Kojima, Manabu Katou, Masafumi Iwatsu, Nobuyuki Tanaka, Masahiko Fujioka
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Publication number: 20150158833Abstract: The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.Type: ApplicationFiled: February 19, 2015Publication date: June 11, 2015Inventors: Akira KUGIMIYA, Masahiko FUJIOKA, Yuki TACHIBANA, Takami MURASHI, Naohiro ONODERA
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Patent number: 8993763Abstract: The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.Type: GrantFiled: September 25, 2006Date of Patent: March 31, 2015Assignee: Shionogi & Co., Ltd.Inventors: Akira Kugimiya, Masahiko Fujioka, Yuki Tachibana, Takami Murashi, Naohiro Onodera
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Publication number: 20140194420Abstract: Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, —S—, —O—, —NR5—, —C(?O)— or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.Type: ApplicationFiled: July 13, 2012Publication date: July 10, 2014Applicant: Shionogi & Co., Ltd.Inventors: Eiichi Kojima, Keisuke Tonogaki, Nobuyuki Tanaka, Manabu Katou, Akira Ino, Masafumi Iwatsu, Masahiko Fujioka, Yu Hinata, Naoki Ohyabu
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Patent number: 8730623Abstract: Disclosed is a head stack assembly, which comprises a pivot bearing assembly having a main body which comprising a first end surface and a second end surface, and a flange extended from the main body and located between the first and second end surfaces, the flange having a first interface adjacent the first end surface of the main body and a second interface opposite to the first interface; a drive arm mounted on the main body and secured on the first interface of the flange; and a fantail spacer mounted on the main body and secured on the second interface of the flange.Type: GrantFiled: January 20, 2010Date of Patent: May 20, 2014Assignee: SAE Magnetics (H.K.) Ltd.Inventors: Yiusing Ho, Masahiko Fujioka
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Publication number: 20130184240Abstract: Disclosed is a compound which is useful as an AMPK activator. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein a group represented by the formula: is a group represented by the formula: R1 is each independently halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like; m is an integer of 0 to 3; R2 is hydrogen, or substituted or unsubstituted alkyl; X is —O—; and Y is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.Type: ApplicationFiled: September 8, 2011Publication date: July 18, 2013Applicant: Shionogi & Co., Ltd.Inventors: Keisuke Tonogaki, Akira Ino, Eiichi Kojima, Manabu Katou, Masafumi Iwatsu, Nobuyuki Tanaka, Masahiko Fujioka
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Patent number: 8153793Abstract: The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.Type: GrantFiled: November 20, 2009Date of Patent: April 10, 2012Assignee: Shionogi & Co., Ltd.Inventors: Akira Kugimiya, Masahiko Fujioka, Yuki Tachibana, Takami Murashi
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Publication number: 20110176239Abstract: Disclosed is a head stack assembly, which comprises a pivot bearing assembly having a main body which comprising a first end surface and a second end surface, and a flange extended from the main body and located between the first and second end surfaces, the flange having a first interface adjacent the first end surface of the main body and a second interface opposite to the first interface; a drive arm mounted on the main body and secured on the first interface of the flange; and a fantail spacer mounted on the main body and secured on the second interface of the flange.Type: ApplicationFiled: January 20, 2010Publication date: July 21, 2011Applicant: SAE Magnetics (H.K.) Ltd.Inventors: Yiusing Ho, Masahiko Fujioka
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Publication number: 20110172217Abstract: The present invention provides compounds or a pharmaceutically acceptable salt thereof which inhibit the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and are therefore useful for the prophylaxis/therapy of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. The above problem was solved by providing a ring-fused morpholine compound shown in the present specification, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: September 2, 2009Publication date: July 14, 2011Applicant: Shionogi & Co., Ltd.Inventors: Masahiko Fujioka, Susumu Mitsumori, Akira Kugimiya, Daisuke Taniyama
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Publication number: 20110105457Abstract: The purpose of the present invention is to provide a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prevention/treatment of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. This was achieved by providing a substituted 2-amino-5,6-nitrogenated fused ring compound shown in the present specification, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: April 16, 2009Publication date: May 5, 2011Inventors: Daisuke Taniyama, Kazuya Kano, Kazuya Okamoto, Masahiko Fujioka, Yasunori Mitsuoka
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Publication number: 20100069638Abstract: The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (II): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the ring C is an aromatic carbocyclic ring etc.; R1 is carboxy etc.; R2 is independently a halogen atom etc.; R3 is optionally substituted alkyloxy etc.; R4 is independently a halogen atom etc.; R5 is independently optionally substituted alkyl etc.; M is sulfonyl etc.; Y is a single bond etc.; L1 is a single bond etc.; L2 is a single bond etc.; k is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and q is 0, 1, 2 or 3; provided that a) k is not 0 when the ring B is a 6-membered nitrogen-containing heterocyclic ring containing one or two nitrogen atom(s) and the ring C is a benzene ring, etc.Type: ApplicationFiled: November 20, 2009Publication date: March 18, 2010Inventors: Akira Kugimiya, Masahiko Fujioka, Yuki Tachibana, Takami Murashi
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Patent number: 7626811Abstract: A low profile disk drive unit includes a disk; a HSA cooperating with the disk; a base plate comprising a bottom portion for supporting the disk and the head stack assembly thereon and a base plate sidewall extending from circumference of the bottom portion; and a top cover comprising a top portion and a top cover sidewall extending from circumference of the top portion and assembled with the base plate; wherein the top cover sidewall is thinner than the base plate sidewall, and the base plate sidewall is lower than the disk with the bottom portion as a reference datum so as to define an airflow channel between a periphery of the disk and the top cover sidewall of the top cover.Type: GrantFiled: July 26, 2007Date of Patent: December 1, 2009Assignee: SAE Magnetics (H.K.) Ltd.Inventors: Takehiro Kamigama, Masahiko Fujioka, YiuSing Ho, Yi Wan
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Publication number: 20080180855Abstract: A voice coil motor for use in a disk drive device suitable for causing rotation of a head gimbal assembly connected to a first end of the voice coil motor is provided. At least one protrusion may protrude from a second end of the voice coil motor, with the second end of the voice coil motor being opposed to the first end. The voice coil motor may be rotatable to move a head connected to the head gimbal assembly for a read and/or write operation and for parking. The protrusion may be disposed on the voice coil motor so as to cooperate with a single pin to define first and second maximum positions beyond which the voice coil motor cannot rotate. In certain example embodiments, the first maximum position may be a load position limit beyond which the voice coil motor cannot rotate during a read/write operation, and the second maximum position may be a park position limit beyond which the voice coil motor cannot rotate when the head is parked.Type: ApplicationFiled: January 31, 2007Publication date: July 31, 2008Applicant: SAE Magnetics (H.K.) Ltd.Inventors: Masahiko Fujioka, Yiu Sing Ho, Yi Wan
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Publication number: 20080024973Abstract: A low profile disk drive unit includes a disk; a HSA cooperating with the disk; a base plate comprising a bottom portion for supporting the disk and the head stack assembly thereon and a base plate sidewall extending from circumference of the bottom portion; and a top cover comprising a top portion and a top cover sidewall extending from circumference of the top portion and assembled with the base plate; wherein the top cover sidewall is thinner than the base plate sidewall, and the base plate sidewall is lower than the disk with the bottom portion as a reference datum so as to define an airflow channel between a periphery of the disk and the top cover sidewall of the top cover.Type: ApplicationFiled: July 26, 2007Publication date: January 31, 2008Applicant: SAE Magnetics (H.K.) Ltd.Inventors: Takehiro Kamigama, Masahiko Fujioka, YiuSing Ho, Yi Wan
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Publication number: 20070171578Abstract: A HSA for a disk drive unit includes at least one drive arms, each of which has a mounting hole formed thereon; at least one HGAs, each of which connecting with one of the at least one drive arms; a fantail spacer having a mounting hole; and a bearing assembly; wherein the bearing assembly respectively extends through the mounting holes of the at least one drive arms and the fantail spacer and fastens them together; wherein each of the drive arms has at least one first positioning elements, and the fantail spacer has at least one second positioning elements each of which engaging with one of the first positioning elements. Also disclosed is a manufacturing method of the HSA.Type: ApplicationFiled: March 31, 2006Publication date: July 26, 2007Applicant: SAE Magnetics(H.K.) LtdInventors: Takehiro Kamigama, Masahiko Fujioka, YiuSing Ho, Hiroshi Fukaya