Abstract: There are provided pharmaceutical formulations with improved oral absorptivity and injections that contain, as active ingredients, high concentrations of benzamide derivatives and their pharmaceutically acceptable salts, which are useful as histone deacetylase inhibitors. A pharmaceutical solution is prepared by dissolving a benzamide derivative or a pharmaceutically acceptable salt thereof in an organic solvent and/or acidic liquid, and a pharmaceutical formulation is prepared by adding a surfactant, an acidic substance and/or a polyethylene glycol. The present invention has enabled dissolution of benzamide derivatives or their pharmaceutically acceptable salts at high concentrations, to prepare practical injections and oral liquid formulations and improve absorptivity with oral administration.

Abstract: A thrombolytic composition containing tissue type plasminogen activator or a derivative thereof in combination with an anionic polymer or a salt thereof and an amine compound or a salt thereof or in combination with an anionic polymer or a salt thereof, an amine compound and an acid or a salt thereof. The composition is an aqueous solution or a lyophilized preparation which can be stably dissolved on dilution at near neutral pH in both pharmaceutical solutions having high salt concentrations, such as physiological saline, and pharmaceutical solutions having low salt concentrations, such as a 5% glucose solution. Clinically useful products for infusion or injection are prepared to be used at a pH near neutral.