Abstract: A rotary tool of the present aspect has a body and a cutting edge positioned on the outer periphery of the body. The cutting edge has a first section and a second section when viewed on an imaginary plane defined by cutting a rotational trajectory of the rotary tool on a plane including a rotational axis. The first section has a first region and a second region. A first radius of curvature of the first region is greater than a second radius of curvature of the second region in at least one of a plurality of the first sections.

Abstract: Provided are an miR-29a-like nucleic acid reagent and a pharmaceutical composition that aim to inhibit liver fibrosis. An miR-29a-like nucleic acid reagent according to the present invention includes nucleic acid having a base sequence of Sequence ID No. 1 that includes DNA and RNA and in which at least one nucleotide residue is a modified residue: Sequence ID No. 1: uagcaccaggctgucc. A liver fibrosis inhibitor and a pharmaceutical composition according to the present invention include the miR-29a-like nucleic acid reagent according to the present invention, and are preferably used for oral administration.

Abstract: A drill may include a body which is extended along a rotation axis from a first end to a second end. The body may include a first cutting edge, a second cutting edge, a thinning surface, a flute, and an outer peripheral surface. The outer peripheral surface may include a first margin surface, a clearance surface, and a second margin surface. In a plan view of the first end, an imaginary straight line connecting the rotation axis and an end part on a side of an outer periphery in the first cutting edge may be a first straight line, and an imaginary straight line which passes through a center of the first straight line and is orthogonal to the first straight line may be a second straight line. The second straight line may intersect with the second margin surface.

Abstract: Provided is a novel carrier for introducing a nucleic acid such as a siRNA into a cell. The carrier for a nucleic acid of the present invention includes vesicles from a plant in the family Malpighiaceae, and preferably vesicles derived from acerola. A method for administering a nucleic acid according to the present invention includes forming a conjugate of the carrier for a nucleic acid of the present invention and a nucleic acid and administering the conjugate.

Abstract: A rotary tool of the present aspect has a body and a cutting edge positioned on the outer periphery of the body. The cutting edge has a first section and a second section when viewed on an imaginary plane defined by cutting a rotational trajectory of the rotary tool on a plane including a rotational axis. The first section has a first region and a second region. A first radius of curvature of the first region is greater than a second radius of curvature of the second region in at least one of a plurality of the first sections.

Abstract: A rotary tool of the present aspect has a body and a cutting edge positioned on the outer periphery of the body. The cutting edge has a first section and a second section when viewed on an imaginary plane defined by cutting a rotational trajectory of the rotary tool on a plane including a rotational axis. The first section has a first region and a second region. A first radius of curvature of the first region is greater than a second radius of curvature of the second region in at least one of a plurality of the first sections.

Abstract: A rotary tool may include a main body having a bar-shape. The main body may include a cutting edge part at a first end, and a shank part at a second end. The cutting edge part may include a base member including a plurality of ridges, and a coating layer located on at least the ridges. The coating layer may include a layer containing SixM1-x(C1-yNy) (where M is at least one kind selected from Ti, Al, Cr, W, Mo, Ta, Hf, Nb, Zr, and Y, 0.01?x?0.55, and 0?y?1). A first region of the coating layer is closer to the first end than a second region of the coating layer, which is further away from the first end than the first region, and a content ratio of Si in the first region is lower than a content ratio of Si in the second region.

Abstract: The invention provides an artificial match-type miRNA utilizing miRNA. In particular, the invention provides a single strand nucleic acid containing an X region and a Y region, wherein the 3?-terminal of the X region and the 5?-terminal of the Y region are linked via a linker region of a non-nucleotide structure, the X region contains a guide strand sequence of a mature miRNA, and the Y region contains a sequence completely complementary to the X region is an artificial match-type miRNA. The artificial match-type miRNA can suppress expression of the target gene.

Abstract: The present disclosure is directed to an artificial mimic miRNA utilizing miRNA. An artificial mimic miRNA is a single-stranded nucleic acid including: a X region; and a Y region, the Y region and the X region being linked, wherein the X region is a guide strand sequence of a mature miRNA or a partial sequence of the guide strand sequence of the mature miRNA and consists of a linking side region (XB) and a non-linking side region (XF) to the Y region, the linking side region (XB) is a sequence that does not cause intramolecular annealing within its region, and the Y region is a sequence that intramolecularly anneals to the non-linking side region (XF) of the X region. According to the artificial mimic miRNA of the present invention, the expression of the target gene can be inhibited.

Abstract: An end mill includes a bar-shaped body, a cutting edge, a gash, a first flute, and a second flute. The body extends from a first end to a second end along a rotation axis. The cutting edge is located at a side of the first end of the body. The gash is located adjacent to the cutting edge. The first flute surrounds the gash and spirally extends from the gash toward the second end. The second flute surrounds the first flute and spirally extends from the first flute toward the second end. A depth of the first flute is greater than a depth of the second flute in a cross section orthogonal to the rotation axis.

Abstract: A rotary tool of the present aspect has a body and a cutting edge positioned on the outer periphery of the body. The cutting edge has a first section and a second section when viewed on an imaginary plane defined by cutting a rotational trajectory of the rotary tool on a plane including a rotational axis. The first section has a first region and a second region. A first radius of curvature of the first region is greater than a second radius of curvature of the second region in at least one of a plurality of the first sections.

Abstract: [Object] To provide a ball end mill in which it is possible to improve wear resistance in the vicinity of the central axis at the tip of a ball-nosed end cutting edge and to suppress vibration of a tool body during machining. [Solution] A ball end mill 10 includes: a tool body 1 that rotates about a central axis O; and an arc-shaped ball-nosed end cutting edge 2 in a side view which is provided to start from the central axis O side on a tip side of the tool body 1 toward a rear side thereof. The ball-nosed end cutting edge 2 has a radius of curvature r that becomes gradually smaller from the central axis O side toward a periphery Q side.

Abstract: An end mill includes end cutting edges located at a front end side of a cutting edge portion of a body including rotation axis, peripheral cutting edges, and helically extending flutes. Each of the peripheral cutting edges and the flutes are alternately located from the front end side to a rear end side, and a first distance between a deepest position of the flute and the rotation axis is equal among the respective flutes in a cross section taken along the rotation axis. The flute includes a first region located at a side of the peripheral cutting edge and includes the deepest position, a second region located at a side of a heel, and a boundary. A second distance from the rotation axis to the boundary located at the rear end side is larger than the second distance located at the front end side.

Abstract: A rotary tool may include a main body having a bar-shape. The main body may include a cutting edge part at a first end, and a shank part at a second end. The cutting edge part may include a base member including a plurality of ridges, and a coating layer located on at least the ridges. The coating layer may include a layer containing SixM1-x(C1-yNy) (where M is at least one kind selected from Ti, Al, Cr, W, Mo, Ta, Hf, Nb, Zr, and Y, 0.01?x?0.55, and 0?y?1). A first region of the coating layer is closer to the first end than a second region of the coating layer, which is further away from the first end than the first region, and a content ratio of Si in the first region is lower than a content ratio of Si in the second region.

Abstract: A end mill includes: an end mill body having a rotation axis, the end mill body including a shank portion and a cutting portion with an outer peripheral cutting edge; an end cutting edge including a first cutting edge and a second cutting edge; a first gash opening between the first cutting edge and the second cutting edge; and a second gash located adjacently to the first gash in the rotational direction, and opening to a side closer to the outside peripheral from the chisel portion. A ratio (L1/L2) of a length (L1) from a distal end of the end mill body to a terminal end of the first gash to a length (L2) from the distal end of the end mill body to a terminal end of the second gash, when viewed from a side, is from 0.8 to 1.1.

Abstract: The drill (1) is provided with a drill body (2) having a rotation center axis (O), two cutting edges (3) provided on the tip side of the drill body (2), and chip evacuation flutes (10) provided behind the two cutting edges (3) in the direction of rotation of the drill (1) from the two cutting edges, the drill tip angle (?) being from 170 to 190°, the web thickness (d) being from 0.10 to 0.25 times the drill diameter (D), the opening angle (?) of the chip evacuation flutes (10) being from 85 to 110°, and the drill (1) comprising a curve having a radius of curvature that gradually decreases from the cutting edge side wall surface (14) to the heel side wall surface (15) of the chip evacuation flutes (10) in a cross-section at a position where the chip evacuation flutes (10) are present.

Abstract: The present invention provides a single-stranded nucleic acid molecule inhibiting expression of a prorenin gene or a prorenin receptor gene, comprising only region (X), linker region (Lx) and region (Xc), wherein the aforementioned linker region (Lx) has a non-nucleotide structure comprising at least one of a pyrrolidine skeleton and a piperidine skeleton, and at least one of the aforementioned region (X) and the aforementioned region (Xc) comprises an expression inhibitory sequence comprising a nucleotide sequence consisting of at least 18 continuous nucleotides in any of an expression inhibitory sequence of a prorenin gene shown in SEQ ID NO: 1 to 5 and an expression inhibitory sequence of prorenin receptor gene shown in SEQ ID NO: 6 to 11.

Abstract: The present invention aims to provide a novel test method for evaluating the possibility of cervical cancer and a novel test reagent for use in the method. The present invention provides a test method for evaluating the possibility of cervical cancer, including the step of: detecting the MUC expression in a biological sample isolated from the uterine cervix.

Abstract: An end mill includes a bar-shaped body, a cutting edge, a gash, a first flute, and a second flute. The body extends from a first end to a second end along a rotation axis. The cutting edge is located at a side of the first end of the body. The gash is located adjacent to the cutting edge. The first flute surrounds the gash and spirally extends from the gash toward the second end. The second flute surrounds the first flute and spirally extends from the first flute toward the second end. A depth of the first flute is greater than a depth of the second flute in a cross section orthogonal to the rotation axis.

Abstract: An end mill includes a body including an axis, first cutting edges on a side of a front end of the body, second cutting edges at a rear side of the respective first cutting edges, flutes located along the second cutting edges, and heels located along the flutes. A shape of each of the flutes in a cross section includes a first concave curve on a side of the second cutting edges, a second concave curve on a side of the heels, and a protrusion located between the two concave curves, the protrusion includes two concave curves intersect each other, and a ratio of a distance from a circle including a maximum diameter in the body centered on the axis to a top of the protrusion to a distance H from the circle to the second cutting edge is 0.1 to 0.4.