Patents by Inventor Masahira Hattori

Masahira Hattori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180140645
    Abstract: The diatheses of animals vary depending on genetic backgrounds of the animals, and the microbial structure of an enterobacterial flora inherent in a host and the behavior of the concentration of a biological molecule sometimes vary depending on the diathesis of the host. In this case, it is needed to administer a proper probiotic. Provided is a microbial preparation for controlling the proportion of the population of bacteria belonging to the division Bacteroidetes, Firmicutes or Proteobacteria or the proportion of the population of bacteria belonging to the genus Clostridium, Lactobacillus, Bifidobacterium or Bacteroidetes in the enterobacterial florae in an animal body, and for controlling the concentration of a functional molecule contained in a living body, said microbial preparation containing a microorganism P01931 (International Accession No. BP-1931), MK-01A (International Accession No. BP-02066) or MK-03A (International Accession No. BP-02067) or a component of the microorganism.
    Type: Application
    Filed: March 4, 2016
    Publication date: May 24, 2018
    Inventors: Hirokuni MIYAMOTO, Hiroaki KODAMA, Hiroshi OHNO, Shinji FUKUDA, Masahira HATTORI, Kenshiro OSHIMA, Wataru SUDA, Toshiyuki ITO, Hisashi MIYAMOTO
  • Publication number: 20170216378
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Application
    Filed: April 14, 2017
    Publication date: August 3, 2017
    Applicants: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: KENYA HONDA, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Publication number: 20170209502
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Application
    Filed: March 28, 2017
    Publication date: July 27, 2017
    Applicants: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Patent number: 9649345
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: May 16, 2017
    Assignees: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Patent number: 9642881
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: May 9, 2017
    Assignees: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Publication number: 20170028061
    Abstract: Strains of human-derived bacteria have been obtained from complex fecal samples and shown to induce accumulation of Th17 cells in the intestine and promote immune functions. Pharmaceutical compositions containing these bacteria can be used as anti-infectives and as adjuvants in mucosal vaccines.
    Type: Application
    Filed: April 10, 2015
    Publication date: February 2, 2017
    Applicants: RIKEN, The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Masahira Hattori, Hidetoshi Morita
  • Publication number: 20160193257
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Application
    Filed: February 9, 2016
    Publication date: July 7, 2016
    Applicants: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Publication number: 20160193256
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Application
    Filed: February 9, 2016
    Publication date: July 7, 2016
    Applicants: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Publication number: 20160145564
    Abstract: Provided are a functional microbial material and a method for producing a fermentation product, wherein the functional microbial material and the fermentation product are environment-friendly and improve the quality of crops. The present invention relates to a microbial material and a method for producing a fermentation product wherein the microbial material and the fermentation product are obtained by fermentation of a fermentation raw material including a plant-derived raw material and an animal-derived raw material using a population of microorganisms including a plurality of species of thermophilic microorganisms, and lead to a remedy for soil and water pollution and to the inhibition of greenhouse gas generation, as well as contribute to improvements in the functionality of plants, particularly the expression of genes involved in biophylaxis and resistant to high-temperature disorder, and an increase in antioxidant components.
    Type: Application
    Filed: June 28, 2013
    Publication date: May 26, 2016
    Inventors: Hirokuni Miyamoto, Kiroaki Kodama, Hisashi Miyamoto, Takumi Nishiuchi, Kazuto Ishikawa, Kazuo Ogawa, Toshiyuki Ito, Takuya KAMITAI, Kenshiro Oshima, Wataru Suda, Masahira Hattori
  • Publication number: 20150306153
    Abstract: To provide a mixture, a dissolving solution and a pharmaceutical agent, which contain a thermophilic microorganism to make it possible to regulate a mucous membrane immune system gene cluster and metabolism-related gene clusters of the intestines and the liver. Each of them is prepared by fermentation of an organic material containing a thermophilic microorganism at a temperature of 50° C. or more and 90° C. or less. By being administered to the animal, it regulates at least one of a mucous membrane immune system gene cluster, a metabolism-related gene cluster in the intestines, and a metabolism-related gene cluster in the liver of the animal. The microorganism includes at least one species of the genus Bacillus, Oceanobacillus, Paenibacillus, Anoxybacillus, Lysinibacillus, Methanopyrus, Geogemma, Pyrolobus, Pyrodictium, Hyperthermus, Pyrococcus, Pyrobaculum, Thermococcus, Aeropyrum, Aquifex, Thermotoga, Thermodesulfobacterium, Thermus, Geobacillus, and Thermomyces.
    Type: Application
    Filed: July 9, 2015
    Publication date: October 29, 2015
    Inventors: Hirokuni Miyamoto, Hiroaki Kodama, Takumi Nishiuchi, Teruo Matsushita, Hisashi Miyamoto, Sankichi Horiuchi, Manami Seta, Kenichi Mori, Masahira Hattori, Kazuo Ogawa
  • Publication number: 20140341921
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Application
    Filed: November 29, 2012
    Publication date: November 20, 2014
    Applicants: The University of Tokyo, School Corporation , Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Publication number: 20120301450
    Abstract: To provide a mixture, a dissolving solution and a pharmaceutical agent, which contain a thermophilic microorganism to make it possible to regulate a mucous membrane immune system gene cluster and metabolism-related gene clusters of the intestines and the liver. Each of them is prepared by fermentation of an organic material containing a thermophilic microorganism at a temperature of 50° C. or more and 90° C. or less. By being administered to the animal, it regulates at least one of a mucous membrane immune system gene cluster, a metabolism-related gene cluster in the intestines, and a metabolism-related gene cluster in the liver of the animal. The microorganism includes at least one species of the genus Bacillus, Oceanobacillus, Paenibacillus, Anoxybacillus, Lysinibacillus, Methanopyrus, Geogemma, Pyrolobus, Pyrodictium, Hyperthermus, Pyrococcus, Pyrobaculum, Thermococcus, Aeropyrum, Aquifex, Thermotoga, Thermodesulfobacterium, Thermus, Geobacillus, and Thermomyces.
    Type: Application
    Filed: February 9, 2011
    Publication date: November 29, 2012
    Inventors: Hirokuni Miyamoto, Hiroaki Kodama, Takumi Nishiuchi, Teruo Matsushita, Hisashi Miyamoto, Sankichi Horiuchi, Manami Seta, Kenichi Mori, Masahira Hattori, Kazuo Ogawa
  • Patent number: 7630836
    Abstract: Novel polynucleotides derived from microorganisms belonging to actinomycetes and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: December 8, 2009
    Assignees: The Kitasato Institute, National Institute of Technology and Evaluation
    Inventors: Satoshi Omura, Haruo Ikeda, Jun Ishikawa, Hiroshi Horikawa, Tadayoshi Shiba, Yoshiyuki Sakaki, Masahira Hattori
  • Patent number: 7238796
    Abstract: Human BMCC1 protein having an amino acid sequence set forth in SEQ ID NO:1 in the Sequence Listing and its variant protein, as well as human BMCC1 gene having a base sequence set forth in SEQ ID NO:2 in the Sequence Listing and its variant gene.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: July 3, 2007
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Akira Nakagawara, Masahira Hattori, Yoshiyuki Sakaki
  • Publication number: 20050064413
    Abstract: Human BMCC1 protein having an amino acid sequence set forth in SEQ ID NO:1 in the Sequence Listing and its variant protein, as well as human BMCC1 gene having a base sequence set forth in SEQ ID NO:2 in the Sequence Listing and its variant gene.
    Type: Application
    Filed: August 23, 2002
    Publication date: March 24, 2005
    Applicant: Hisamitsu Pharmaceutical co., Inc.
    Inventors: Akira Nakagawara, Masahira Hattori, Yoshiyuki Sakaki
  • Patent number: 6632935
    Abstract: The present invention provides a genomic DNA of Buchnera. That is, this invention provides genes derived from Buchnera sp., comprising DNA of the following (a) or (b); (a) a DNA selected from a group consisting of a DNA having a nucleotide sequence ranging from a start point to an end point as shown in Table 1 in a nucleotide sequence represented by SEQ ID NO:1, or a DNA complementary thereto, and (b) a DNA hybridizing to the DNA of (a) under stringent conditions and encoding a protein having a function same as that of the product expressed by the DNA.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: October 14, 2003
    Assignee: Riken
    Inventors: Shuji Shigenobu, Hidemi Watanabe, Hajime Ishikawa, Masahira Hattori, Yoshiyuki Sakaki
  • Publication number: 20030119018
    Abstract: Novel polynucleotides derived from microorganisms belonging to actinomycetes and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them.
    Type: Application
    Filed: May 29, 2002
    Publication date: June 26, 2003
    Inventors: Satoshi Omura, Haruo Ikeda, Jun Ishikawa, Hiroshi Horikawa, Tadayoshi Shiba, Yoshiyuki Sakaki, Masahira Hattori
  • Publication number: 20020127687
    Abstract: The present invention provides genomic DNA of Buchnera. That is, this invention provides genes derived from Buchnera sp.
    Type: Application
    Filed: February 23, 2001
    Publication date: September 12, 2002
    Inventors: Shuji Shigenobu, Hidemi Watanabe, Hajime Ishikawa, Masahira Hattori, Yoshiyuki Sakaki