Patents by Inventor Masahiro Fuji
Masahiro Fuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170066754Abstract: The present invention provides an integrase inhibitor. The inventors have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, RC and RD taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxyl, mercapto or amino; Z is O, S or NH; RA is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like).Type: ApplicationFiled: November 18, 2016Publication date: March 9, 2017Applicant: SHIONOGI & CO., LTD.Inventors: Ryuichi KIYAMA, Yasuhiko KANDA, Yukio TADA, Toshio FUJISHITA, Takashi KAWASUJI, Shozo TAKECHI, Masahiro FUJI
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Patent number: 9572813Abstract: The present invention provides an integrase inhibitor. The inventors have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, RC and RD taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxyl, mercapto or amino; Z is O, S or NH; RA is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like).Type: GrantFiled: January 23, 2015Date of Patent: February 21, 2017Assignee: Shionogi & Co., Ltd.Inventors: Ryuichi Kiyama, Yasuhiko Kanda, Yukio Tada, Toshio Fujishita, Takashi Kawasuji, Shozo Takechi, Masahiro Fuji
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Publication number: 20150202208Abstract: The present invention provides an integrase inhibitor. The inventors have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, RC and RD taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxyl, mercapto or amino; Z is O, S or NH; RA is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like).Type: ApplicationFiled: January 23, 2015Publication date: July 23, 2015Inventors: Ryuichi KIYAMA, Yasuhiko KANDA, Yukio TADA, Toshio FUJISHITA, Takashi KAWASUJI, Shozo TAKECHI, Masahiro FUJI
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Patent number: 7759372Abstract: A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.Type: GrantFiled: August 8, 2006Date of Patent: July 20, 2010Assignee: Shionogi & Co., Ltd.Inventors: Masahiro Fuji, Hidenori Mikamiyama, Hitoshi Murai
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Publication number: 20060293334Abstract: A compound of the formula (I): wherein Z4, Z5 and Z9each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.Type: ApplicationFiled: August 8, 2006Publication date: December 28, 2006Inventors: Masahiro Fuji, Hidenori Mikamiyama, Hitoshi Murai
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Patent number: 7148237Abstract: A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.Type: GrantFiled: February 27, 2002Date of Patent: December 12, 2006Assignee: Shionogi & Co., Ltd.Inventors: Masahiro Fuji, Hidenori Mikamiyama, Hitoshi Murai
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Publication number: 20040256376Abstract: A stable and durable heat-generating element and substrate, a method of efficient and highly precise manufacture of same, and equipment utilizing same are obtained. Employing as material a silicon substrate into at least a portion of which boron or another impurity is diffused to impart conductivity, a heater portion, in which are provided one or a plurality of slits the corner portions of which are removed or are rounded, is fabricated integrally on the silicon substrate by etching processes. Simultaneously with this, a depression portion provided below to control the heating state of the heater portion is formed integrally.Type: ApplicationFiled: June 20, 2003Publication date: December 23, 2004Inventors: Katsuji Arakawa, Masahiro Fuji, Hiroshi Koeda
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Publication number: 20040229909Abstract: The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity.Type: ApplicationFiled: January 30, 2004Publication date: November 18, 2004Inventors: Ryuichi Kiyama, Yasuhiko Kanda, Yukio Tada, Toshio Fujishita, Takashi Kawasuji, Shozo Takechi, Masahiro Fuji
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Patent number: 6787545Abstract: The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein R1 is C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocyclic groups or the like; R2 is a hydrogen atom or a group containing 1 to 4 non-hydrogen atoms; RA is —COCONH2 or the like; R3 is -(L2)-(acidic group) wherein L2 is a group connecting with an acid group; R4 is a hydrogen atom or the like, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.Type: GrantFiled: February 20, 2002Date of Patent: September 7, 2004Assignee: Shiongi & Co., Ltd.Inventors: Mitsuaki Ohtani, Masahiro Fuji, Tomoyuki Ogawa
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Publication number: 20040127708Abstract: A compound of the formula (I): 1Type: ApplicationFiled: August 18, 2003Publication date: July 1, 2004Inventors: Masahiro Fuji, Hidenori Mikamiyama, Hitoshi Murai
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Patent number: 6756376Abstract: The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein E is N or C—R4; G is N or C—R25; R1 is a carbocyclic group, heterocyclic group or the like; one of R3 and R4 is —(L2)-(acidic group), the other is a hydrogen atom, wherein L2 is a group connecting with an acid group; A ring is optionally substituted 5-8 membered cyclohexane ring or cyclohexene ring; R24 and R25 are a hydrogen atom or the like, its prodrug, their pharmaceutically acceptable salt, or hydrate thereof.Type: GrantFiled: May 9, 2002Date of Patent: June 29, 2004Assignee: Shionogi & Co., Ltd.Inventors: Masahiro Fuji, Tetsuo Okada, Makoto Adachi
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Patent number: 6703385Abstract: The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocyclic groups or the like; R2 is COCONH2 or the like; Q1 is a nitrogen atom or C—R4; one of R3 and R4 is —(L2)-(acidic group) wherein L2 is a group connecting with an acid group and the length of the connecting groups 1 to 5 atoms, and the other is a hydrogen atom; R21 and R22 are hydrogen atoms or the like; X is —CR23R24— or the like wherein R23 and R24 are hydrogen atoms or the like; Y is —CR25R26— or the like wherein R25 and R26 are hydrogen atoms or the like; Z is CH2 or the like; a broken line ( - - - ) represents the presence or absence of a bond, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.Type: GrantFiled: January 22, 2002Date of Patent: March 9, 2004Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Masahiro Fuji, Makoto Adachi, Tomoyuki Ogawa
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Patent number: 6673781Abstract: The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocyclic groups or the like; R2 is CONH2 or CONHNH2; one of R3 and R4 is —(L2)-(acidic group) wherein L2 is a group connecting with an acid group and the length of the connecting groups 1 to 5 atoms, and the other is a hydrogen atom; its prodrug, their pharmaceutically acceptable salt, or solvate thereof.Type: GrantFiled: February 1, 2002Date of Patent: January 6, 2004Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Masahiro Fuji, Tetsuo Okada, Makoto Adachi, Tomoyuki Ogawa
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Patent number: 6472389Abstract: The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein R1 is —(L1)—R6 wherein L1 is a divalent linking group of 1 to 18 atoms or the like, and R6 is a carbocyclic ring substituted by at least one non-interfering substituent or the like; R2 is C1 to C3 alkyl or the like; R3 is —(L2)-(acidic group); R4 and R5 are hydrogen atoms, non-interfering substituents, carbocyclic groups or the like; X is independently oxygen atom of sulfur atom; and RA is —C(═X)—C(═X)—NH2 or the like; the prodrugs thereof, their pharmaceutically acceptable salts, or their solvates, and a composition for inhibiting sPLA2 containing them as effective ingredients.Type: GrantFiled: October 18, 2000Date of Patent: October 29, 2002Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Masahiro Fuji, Yoshikazu Fukui, Makoto Adachi
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Patent number: 6407104Abstract: wherein R1 is —(L1)—R6 wherein L1 is a divalent linking group of 1 to 18 atoms or the like, and R6 is a carbocyclic ring substituted by at least one non-interfering substituent or the like; R2 is C1 to C3 alkyl, C3 to C4 cycloalkyl or the like group; R3 is —(L2)-(acidic group); R4 and R5 are hydrogen atoms, non-interfering substituents, carbocyclic groups or the like; RA is —C(═X)—C(═X)—NH2 or the like; and X is independently oxygen atom or sulfur atom; the prodrugs thereof, their pharmaceutically acceptable salts, or their solvates, and a composition for inhibiting sPLA2 containing them as effective ingredients.Type: GrantFiled: September 5, 2000Date of Patent: June 18, 2002Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Masahiro Fuji, Tetsuo Okada
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Patent number: 5981778Abstract: A method of producing an ether-type thio-phospholipid of the formula (I): ##STR1## wherein: n is an integer of 13 to 17;A is C.sub.14 -C.sub.20 acyl group;G is a group selected from the group consisting of: ##STR2## which is useful as synthetic substrate of cytosolic phospholipase A.sub.2 inhibitors, said method being applicable to mass production of the compound (I), intermediates therefor and the preparation of the same are provided.Type: GrantFiled: March 23, 1998Date of Patent: November 9, 1999Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Masahiro Fuji
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Patent number: 5760270Abstract: A method of producing an ether-type thio-phospholipid of the formula (I): ##STR1## wherein: n is an integer of 13 to 17;A is C.sub.14 -C.sub.20 acyl group;G is a group selected from the group consisting of: ##STR2## which is useful as synthetic substrate of cytosolic phospholipase A.sub.2 inhibitors, said method being applicable to mass production of the compound (I), intermediates therefor and the preparation of the same are provided.Type: GrantFiled: April 23, 1997Date of Patent: June 2, 1998Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Masahiro Fuji
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Patent number: 5663405Abstract: A method of producing an ether-type thio-phospholipid of the formula (I): ##STR1## wherein: n is an integer of 13 to 17;A is C.sub.14 -C.sub.20 acyl group;G is a group selected from the group consisting of: ##STR2## which is useful as synthetic substrate of cytosolic phospholipase A.sub.2 inhibitors, said method being applicable to mass production of the compound (I), intermediates therefor and the preparation of the same are provided.Type: GrantFiled: September 19, 1995Date of Patent: September 2, 1997Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Masahiro Fuji