Abstract: The present invention aims to provide a culturing method and a method for producing a cell population containing a neural crest cell, the methods being able to stably mass produce the neural crest cell from a pluripotent stem cell with quality that allows the cell to be used in a therapy with a cell, and a method for producing a mesenchymal stem cell and the like using the neural crest cell. The method for selectively culturing a neural crest cell in a cell population containing a neural crest cell and/or a neural crest progenitor cell of the present invention comprises a culturing step of adherent culturing the cell population containing the neural crest cell and/or the neural crest progenitor cell, in the presence of one or more prescribed extracellular matrices.

Abstract: A machine tool is provided capable of detecting an abnormality caused by detaching a spindle. The machine tool includes: the spindle configured to rotate a workpiece or a tool; a sensor configured to output a signal according to a rotation angle of the spindle; and a controller configured to detect occurrence of an abnormality in at least one of the spindle and the sensor when an electrical signal different from the signal output during each of rotation of the spindle and halt of the spindle is output from the sensor.

Abstract: A machine tool is provided capable of detecting an abnormality caused by detaching a spindle. The machine tool includes: the spindle configured to rotate a workpiece or a tool; a sensor configured to output a signal according to a rotation angle of the spindle; and a controller configured to detect occurrence of an abnormality in at least one of the spindle and the sensor when an electrical signal different from the signal output during each of rotation of the spindle and halt of the spindle is output from the sensor.