Abstract: Provided is a pharmaceutical composition for treating a tumor, which is used in combination therapy of lenvatinib and (6S,9aS)—N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide.

Abstract: Biomarkers are provided that predict whether a human subject having a renal cell carcinoma is responsive to a combination therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof (e.g., lenvatinib mesylate) and everolimus. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for and treating a subject having, suspected of having, or at risk of developing a renal cell carcinoma.

Abstract: Provided is a pharmaceutical composition for treating a tumor, which is used in combination therapy of lenvatinib and (6S,9aS)—N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide.

Abstract: A therapeutic agent for biliary tract cancer comprising 4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide or a pharmacologically acceptable salt thereof is provided.

Abstract: A seal washer of the present invention includes a metal washer body including a center hole, an outer resilient material projecting from an outer periphery of the washer body to a location lower than a lower surface of the washer body, and an inner resilient material provided on an inner periphery of the washer body which faces the center hole. If a fastening force in an axial direction is applied, since the lower surface of the washer body metal-touches on a mating member, loosening does not occur unlike a conventional technique. In addition, since no further compression load is applied to the resilient material, a phenomenon that the resilient material is deformed in a crushed manner does not occur.

Abstract: A seal washer of the present invention includes a metal washer body including a center hole, an outer resilient material projecting from an outer periphery of the washer body to a location lower than a lower surface of the washer body, and an inner resilient material provided on an inner periphery of the washer body which faces the center hole. If a fastening force in an axial direction is applied, since the lower surface of the washer body metal-touches on a mating member, loosening does not occur unlike a conventional technique. In addition, since no further compression load is applied to the resilient material, a phenomenon that the resilient material is deformed in a crushed manner does not occur.