Patents by Inventor Masahiro Sakaitani

Masahiro Sakaitani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIARYL SULFONAMIDE DERIVATIVE HAVING FILOVIRUS CELL ENTRY INHIBITION ACTIVITY
    Publication number: 20210107871
    Abstract: The objective of the present invention is to provide a novel compound inhibiting the entry of a filovirus into a cell, a medical composition, an anti-filovirus agent, or a filovirus entry inhibitor containing the compound, as well as a method for inhibiting a filovirus cell entry process in vitro, a method for treating a filovirus infectious disease, and the like. The objective has been achieved by providing: the compound represented by formula (I) or a hydrate thereof; or a pharmaceutically acceptable salt of the compound or a hydrate thereof.
    Type: Application
    Filed: March 30, 2018
    Publication date: April 15, 2021
    Applicant: National University Corporation Hokkaido University
    Inventors: Ayato Takada, Masahiro Sakaitani, Wakako Furuyama
  • Quinazolinone and isoquinolinone derivative
    Patent number: 10005739
    Abstract: The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: June 26, 2018
    Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Takeshi Murata, Sousuke Hara, Satoshi Niizuma, Kihito Hada, Hatsuo Kawada, Masahiro Sakaitani, Hideaki Shimada, Yoshito Nakanishi
  • QUINAZOLINONE AND ISOQUINOLINONE DERIVATIVE
    Publication number: 20160272595
    Abstract: The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: October 23, 2014
    Publication date: September 22, 2016
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Takeshi MURATA, Sousuke HARA, Satoshi NIIZUMA, Kihito HADA, Hatsuo KAWADA, Masahiro SAKAITANI, Hideaki SHIMADA, Yoshito NAKANISHI
  • p27 protein inducer
    Patent number: 8569378
    Abstract: The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from —N? etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from —CH2— etc., and R2 is selected from C1-6 alkyl etc.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: October 29, 2013
    Assignees: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Toshiyuki Sakai, Hitoshi Iikura, Ikumi Hyoudoh, Toshihiro Aoki, Noriyuki Furuichi, Masayuki Matsushita, Fumio Watanabe, Sawako Ozawa, Masahiro Sakaitani, Pil-Su Ho, Yasushi Tomii, Kenji Takanashi, Naoki Harada
  • Coumarin derivative having antitumor activity
    Patent number: 8278465
    Abstract: The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N? etc., Y3 and Y4 are selected from —CH? etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: October 2, 2012
    Assignees: Chugai Seiyaku Kabushiki Kaisha, Sakai Toshiyuki
    Inventors: Hitoshi Iikura, Ikumi Hyoudoh, Toshihiro Aoki, Noriyuki Furuichi, Masayuki Matsushita, Fumio Watanabe, Sawako Ozawa, Masahiro Sakaitani, Pil-Su Ho, Yasushi Tomii, Kenji Takanashi, Naoki Harada
  • Glucitol derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
    Patent number: 7943748
    Abstract: The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R1 to R4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: May 17, 2011
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hiroharu Matsuoka, Tsutomu Sato, Masahiro Nishimoto, Yasuhara Kato, Masahiro Sakaitani, Sang-Hak Lee
  • Novel Coumarin Derivative Having Antitumor Activity
    Publication number: 20110092700
    Abstract: The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N? etc., Y3 and Y4 are selected from —CH? etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
    Type: Application
    Filed: December 3, 2010
    Publication date: April 21, 2011
    Inventors: Hitoshi Iikura, Ikumi Hyoudoh, Toshihiro Aoki, Noriyuki Furuichi, Masayuki Matsushita, Fumio Watanabe, Sawako Ozawa, Masahiro Sakaitani, Pil-Su Ho, Yasushi Tomii, Kenji Takanashi, Naoki Harada
  • Coumarin derivative having antitumor activity
    Patent number: 7897792
    Abstract: The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N? etc., Y3 and Y4 are selected from —CH? etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: March 1, 2011
    Assignees: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hitoshi Iikura, Ikumi Hyoudoh, Toshihiro Aoki, Noriyuki Furuichi, Masayuki Matsushita, Fumio Watanabe, Sawako Ozawa, Masahiro Sakaitani, Pil-Su Ho, Yasushi Tomii, Kenji Takanashi, Naoki Harada
  • ?-amino acid derivatives and medicaments containing the same as an active ingredient
    Patent number: 7879887
    Abstract: The present invention provides novel ?-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have ?ARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: February 1, 2011
    Assignees: Nissan Chemical Industries, Ltd., Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kazuhiko Ohrai, Michiaki Adachi, Koji Toyama, Takanori Shimizu, Keishi Hayashi, Masataka Minami, Yoshiyuki Suzuki, Masakazu Sugiyama, Masateru Ohta, Shojiro Kadono, Takuya Shiraishi, Haruhiko Sato, Yoshiaki Watanabe, Nobuya Ishii, Masahiro Sakaitani, Masami Hasegawa
  • p27 Protein Inducer
    Publication number: 20110009398
    Abstract: The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G1, G2, G3 and G8 are each independently selected from —N? etc., Ring G6 is selected from divalent aryl etc., A is selected from amino etc., G4 is selected from oxygen etc., G5 is selected from oxygen etc., G7 is selected from —CH2— etc., and R2 is selected from C1-6 alkyl etc.
    Type: Application
    Filed: July 18, 2008
    Publication date: January 13, 2011
    Inventors: Toshiyuki Sakai, Hitoshi Iikura, Ikumi Hyoudoh, Toshihiro Aoki, Noriyuki Furuichi, Masayuki Matsushita, Fumio Watanabe, Sawako Ozawa, Masahiro Sakaitani, Pil-Su Ho, Yasushi Tomii, Kenji Takanashi, Naoki Harada
  • NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY
    Publication number: 20100004233
    Abstract: The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N? etc., Y3 and Y4 are selected from —CH? etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
    Type: Application
    Filed: February 9, 2007
    Publication date: January 7, 2010
    Inventors: Hitoshi Iikura, Ikumi Hyoudoh, Toshihiro Aoki, Noriyuki Furuichi, Masayuki Matsushita, Fumio Watanabe, Sawako Ozawa, Masahiro Sakaitani, Pil-Su Ho, Yasushi Tomii, Kenji Takanashi, Naoki Harada
  • ALPHA-AMINO ACID DERIVATIVES AND MEDICAMENTS CONTAINING THE SAME AS AN ACTIVE INGREDIENT
    Publication number: 20090275623
    Abstract: The present invention provides novel ?-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have ?ARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.
    Type: Application
    Filed: June 29, 2007
    Publication date: November 5, 2009
    Inventors: Kazuhiko Ohrai, Michiaki Adachi, Koji Toyama, Takanori Shimizu, Keishi Hayashi, Masataka Minami, Yoshiyuki Suzuki, Masakazu Sugiyama, Masateru Ohta, Shojiro Kadono, Takuya Shiraishi, Haruhiko Sato, Yoshiaki Watanabe, Nobuya Ishii, Masahiro Sakaitani, Masami Hasegawa
  • Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes
    Publication number: 20080319047
    Abstract: The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R1 to R4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.
    Type: Application
    Filed: July 27, 2005
    Publication date: December 25, 2008
    Inventors: Hiroharu Matsuoka, Tsutomu Sato, Masahiro Nishimoto, Yasuharu Kato, Masahiro Sakaitani, Sang-Hak Lee
  • N-substituted carbamoyloxyalkyl-azolium derivatives
    Patent number: 7459561
    Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: December 2, 2008
    Assignee: Basilea Pharmaceutica AG
    Inventors: Hiroshi Fukuda, Tadakatsu Hayase, Eisaku Mizuguchi, Nobuo Shimma, Jun Ohwada, Nobuhiro Oikawa, Masahiro Sakaitani, Masao Tsukazaki, Isao Umeda
  • N-phenyl substituted carbamoyloxyalkyl-azolium derivatives
    Patent number: 7189858
    Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives Which have antifungal activity and are useful for the treatment of fungal diseases.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: March 13, 2007
    Assignee: Basilea Pharmaceutica AG
    Inventors: Hiroshi Fukuda, Tadakatsu Hayase, Eisaku Mizuguchi, Nobuo Shimma, Jun Ohwada, Nobuhiro Oikawa, Masahiro Sakaitani, Masao Tsukazaki, Isao Umeda
  • N-substituted carbamoyloxyalkyl-azolium derivatives
    Publication number: 20070027322
    Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.
    Type: Application
    Filed: August 15, 2006
    Publication date: February 1, 2007
    Inventors: Hiroshi Fukuda, Tadakatsu Hayase, Eisaku Mizuguchi, Nobuo Shimma, Jun Ohwada, Nobuhiro Oikawa, Masahiro Sakaitani, Masao Tsukazaki, Isao Umeda
  • Intermediates for N-substituted carbamoyloxyalkyl-azolium derivatives
    Patent number: 7151182
    Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: December 19, 2006
    Assignee: Basilea Pharmaceutica AG
    Inventors: Hiroshi Fukuda, Tadakatsu Hayase, Eisaku Mizuguchi, Nobuo Shimma, Jun Ohwada, Nobuhiro Oikawa, Masahiro Sakaitani, Masao Tsukazaki, Isao Umeda
  • Intermediates for N-substituted carbamoyloxyalkyl-azolium derivatives
    Publication number: 20050038075
    Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.
    Type: Application
    Filed: September 3, 2004
    Publication date: February 17, 2005
    Inventors: Hiroshi Fukuda, Tadakatsu Hayase, Eisaku Mizuguchi, Nobuo Shimma, Jun Ohwada, Nobuhiro Oikawa, Masahiro Sakaitani, Masao Tsukazaki, Isao Umeda
  • N-phenyl substituted carbamoyloxyalkyl-azolium derivatives
    Publication number: 20050038038
    Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives Which have antifungal activity and are useful for the treatment of fungal diseases.
    Type: Application
    Filed: September 3, 2004
    Publication date: February 17, 2005
    Inventors: Hiroshi Fukuda, Tadakatsu Hayase, Eisaku Mizuguchi, Nobuo Shimma, Jun Ohwada, Nobuhiro Oikawa, Masahiro Sakaitani, Masao Tsukazaki, Isao Umeda
  • N-substituted carbamoyloxyalkyl-azolium derivatives
    Patent number: 6812238
    Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: November 2, 2004
    Assignee: Basilea Pharmaceutica AG
    Inventors: Hiroshi Fukuda, Tadakatsu Hayase, Eisaku Mizuguchi, Nobuo Shimma, Jun Ohwada, Nobuhiro Oikawa, Masahiro Sakaitani, Masao Tsukazaki, Isao Umeda