Abstract: The purpose of the present invention is to provide a microneedle array and a microneedle manufacturing method, which improves medical solution delivery efficiency and facilitates manufacturing. The microneedle array is provided with a first divisional element, a second divisional element to be bonded to the first divisional element, a longitudinal passage formed between the first divisional element and the second divisional element bonded to each other; and a horizontal hole, having an orifice on a lateral side and formed in a direction parallel to a bonding surface of the first divisional element with the second divisional element, and communicating to the longitudinal passage.

Abstract: The purpose of the present invention is to provide a microneedle array and a microneedle manufacturing method, which improves medical solution delivery efficiency and facilitates manufacturing. The microneedle array is provided with a first divisional element, a second divisional element to be bonded to the first divisional element, a longitudinal passage formed between the first divisional element and the second divisional element bonded to each other; and a horizontal hole, having an orifice on a lateral side and formed in a direction parallel to a bonding surface of the first divisional element with the second divisional element, and communicating to the longitudinal passage.

Abstract: An object is to provide a method of cutting a laminate film by a circular cutter having a blade around its peripheral edge portion, including rotating the circular cutter at a blade peripheral speed of Vr by a rotational device in a forward rotational direction relative to the cutting direction, while, at the same time, moving the circular cutter at a moving speed of Vc, thereby cutting the laminate film, wherein the relative cutting speed V calculated by subtracting the blade peripheral speed Vr from the moving speed Vc falls within a range of not less than ?50 m/min to not more than 30 m/min.

Abstract: The invention is a method for continuously manufacturing an inspected liquid crystal display panel, includes: a liquid crystal cell feeding step including feeding a liquid crystal cell having a first substrate and a second substrate; a first polarizing plate providing step including providing a first polarizing plate from a first polarizing plate roll; a first polarizing plate laminating step including laminating the first polarizing plate to the first substrate; a second polarizing plate providing step including providing a second polarizing plate from a second polarizing plate roll; a second polarizing plate laminating step including laminating the second polarizing plate to the second substrate to obtain a liquid crystal display panel after laminating the first polarizing plate to the first substrate; and an inspecting step including optically inspecting the liquid crystal display panel without applying voltage to the liquid crystal panel, wherein the first substrate is less susceptible to electrostatic de

Abstract: A method for manufacturing an LCD panel comprises: (a) continuously feeding an LC cell comprising first and second substrates, the first substrate being relatively less susceptible to electrostatic decay than the second substrate, (b) laminating a first polarizing plate to the first substrate of the LC cell while avoiding direct contact between the first laminating member and the first substrate; (c) laminating a second polarizing plate to the second substrate with the first substrate being in contact with a second laminating member through the first polarizing plate laminated to the first substrate in the step (b) while avoiding direct contact between the second laminating member and the first substrate, thereby obtaining an LCD panel, and (d) conducting an inspection of the LCD panel without applying voltage, wherein steps (a), (b), (c) and (d) are performed sequentially in a single continuous feed line.

Abstract: The transdermal administration device of the present invention includes: a needle support with a plurality of microneedles formed at a tip portion thereof; a holder with the needle support placed therein, allowing the needle support to protrude itself therefrom and retract therein; and a cap for covering the microneedles, and further includes: a spring member placed between the needle support and the holder, for biasing the needle support in a protruding direction; an engaging portion at a base of the needle support; and an engaged portion capable of engaging the engaging portion, formed in the holder, where the engaging portion of the needle support can be locked with the engaged portion of the holder when the needle support is retracted in the holder.

Abstract: Disclosed is a substance which has a low molecular weight, can be applied in a simpler manner, and has an immunopotentiating activity against cancer and/or a microorganism-mediated infectious disease. An EP4 agonist exhibits an immunopotentiating activity through the activation of a cytotoxic T cell, and is therefore useful for the prevention and/or treatment of cancer or a microorganism-mediated infection disease.

Abstract: An object is to provide a method of cutting a laminate film by a circular cutter having a blade around its peripheral edge portion, including rotating the circular cutter at a blade peripheral speed of Vr by a rotational device in a forward rotational direction relative to the cutting direction, while, at the same time, moving the circular cutter at a moving speed of Vc, thereby cutting the laminate film, wherein the relative cutting speed V calculated by subtracting the blade peripheral speed Vr from the moving speed Vc falls within a range of not less than ?50 m/min to not more than 30 m/min.

Abstract: The transdermal administration device of the present invention includes: a needle support with a plurality of microneedles formed at a tip portion thereof; a holder with the needle support placed therein, allowing the needle support to protrude itself therefrom and retract therein; and a cap for covering the microneedles, and further includes: a spring member placed between the needle support and the holder, for biasing the needle support in a protruding direction; an engaging portion at a base of the needle support; and an engaged portion capable of engaging the engaging portion, formed in the holder, where the engaging portion of the needle support can be locked with the engaged portion of the holder when the needle support is retracted in the holder.

Abstract: The invention is a method for continuously manufacturing an inspected liquid crystal display panel, includes: a liquid crystal cell feeding step including feeding a liquid crystal cell having a first substrate and a second substrate; a first polarizing plate providing step including providing a first polarizing plate from a first polarizing plate roll; a first polarizing plate laminating step including laminating the first polarizing plate to the first substrate; a second polarizing plate providing step including providing a second polarizing plate from a second polarizing plate roll; a second polarizing plate laminating step including laminating the second polarizing plate to the second substrate to obtain a liquid crystal display panel after laminating the first polarizing plate to the first substrate; and an inspecting step including optically inspecting the liquid crystal display panel without applying voltage to the liquid crystal panel, wherein the first substrate is less susceptible to electrostatic de

Abstract: The transdermal administration device of the present invention includes: a device body including a needle form body, which includes a plurality of microneedles formed on a surface thereof and is provided with a fluid passage hole through the front surface to a back surface thereof, and a medical fluid filling section for providing a medical fluid to the back surface of the needle form body; a stratum corneum peeling system; and a connection section for connecting the device body and the stratum corneum peeling system, where the stratum corneum peeling system is connected to the device body by the connection section such that the microneedles of the needle form body of the device body are positioned in an area of a skin surface in which a stratum corneum is peeled by the stratum corneum peeling system.

Abstract: An EP1 agonist has an immunopotentiating effect mediated by cytotoxic T lymphocyte activation and/or natural killer cell activation, and is thus useful for the prevention and/or treatment of cancers, microbial infectious diseases and the like.

Abstract: Disclosed is a substance which has a low molecular weight, can be applied in a simpler manner, and has an immunopotentiating activity against cancer and/or a microorganism-mediated infectious disease. An EP4 agonist exhibits an immunopotentiating activity through the activation of a cytotoxic T cell, and is therefore useful for the prevention and/or treatment of cancer or a microorganism-mediated infection disease.

Abstract: As a remedy for prurigo, IFN-.gamma. is administered systemically, preferably intravenously and still preferably via drip infusion, in a daily dose of from 250,000 JRU to 4,000,000 JRU preferably once a day or in several portions depending on the conditions of the patient and side effects. The administration method and dose can be changed depending on the conditions, age, etc., of the patient.IFN-.gamma. is highly effective in the treatment of prurigo. The action of IFN-.gamma. to normalize the imbalance in peripheral lymphocytes is suggested as the mechanism for the efficacy of IFN-.gamma. in the treatment of prurigo.

Abstract: A gas ventilation system for an internal combustion engine is provided which includes a downstream intake pipe communicating with cylinders of the engine, an upstream intake pipe communicating with the downstream intake pipe through a throttle valve, and a gas ventilation pipe for recirculating a given gas to the engine. The system also has an inner hollow cylinder connected to the upstream intake pipe, disposed within the downstream intake pipe to define a gas passage between the periphery of the inner cylinder and an inner wall of the downstream intake pipe. The gas passage communicates with the gas ventilation pipe and serves as an isolating member for isolating flow of the gas entering the downstream intake pipe through the gas ventilation pipe from swirls produced by intake air flowing downstream of the throttle valve from the upstream intake pipe.

Abstract: A gas/liquid separator device includes a separator, such as a cyclone type separator, provided in a blowby gas passage for introducing a blowby gas from a blowby gas chamber of an internal combustion engine, an oil accumulator in the form of a container for accumulating separated and condensed oil mist, another passage provided separately from the blowby gas passage for returning the oil from the oil accumulator to an oil collection chamber, and a communication blocking element for blocking a communication between the oil accumulator and the oil collection chamber while the engine is running.

Abstract: A spot welding robot including a base and an arm assembly mounted on the base. The arm assembly includes a lower arm mounted at a lower end on the base for a swingable movement about a substantially horizontal first axis, a swingable member mounted on the lower arm at an upper end portion of the lower arm for a swingable movement about a second axis which is parallel with the first axis, and an upper arm mounted at one end portion on the swingable member for a swingable movement about a third axis which is perpendicular to the second axis. The swingable member has a portion extending in a direction opposite to the direction in which the upper arm extends. A driving motor is provided on the swingable member for driving the upper arm to produce the swingable movement of the upper arm about the third axis.

Abstract: A spot welding robot including a base and an arm assembly mounted on the base. The arm assembly includes a lower arm mounted at a lower end on the base for a swingable movement about a substantially horizontal first axis, a swingable member mounted on the lower arm at an upper end portion of the lower arm for a swingable movement about a second axis which is parallel with the first axis, and an upper arm mounted at one end portion on the swingable member for a swingable movement about a third axis which is perpendicular to the second axis. The swingable member has a portion extending in a direction opposite to the direction in which the upper arm extends. A driving motor is provided on the swingable member for driving the upper arm to produce the swingable movement of the upper arm about the third axis.