Patents by Inventor Masahiro Yagi

Masahiro Yagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the production of 2-hydroxymethyl-3,4,5-trihydroxy piperidine and the corresponding N-methyl derivative
    Patent number: 4339585
    Abstract: Moranoline, or 2-hydroxymethyl-3,4,5-trihydroxy piperidine, is prepared by directly reducing an actinomycetes culture solution containing nojirimycin, followed by isolation, as for example, through the utilization of an ion exchange resin. The corresponding N-methyl derivative can be obtained through the addition of formaldehyde to the culture solution prior to the reduction.
    Type: Grant
    Filed: November 9, 1978
    Date of Patent: July 13, 1982
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoji Ezure, Yoshiaki Yoshikuni, Masahiro Yagi
  • Moranoline derivatives and process for preparation thereof
    Patent number: 4338433
    Abstract: Moranolines are produced which are useful for controlling blood sugar levels.
    Type: Grant
    Filed: December 8, 1980
    Date of Patent: July 6, 1982
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoji Ezure, Yoshiaki Yoshikuni, Masahiro Yagi, Nobutoshi Ojima
  • Quaternary ammonium substituted N-cinnamylpiperidines
    Patent number: 4336374
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxypiperidines bearing a quaternary ammonium-substituted cinnamyl group on the piperidine nitrogen atom and their acid addition salts are antihyperglycemic agents. A typical example is 1-(4-trimethylammoniumcinnamyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine chloride.
    Type: Grant
    Filed: March 26, 1981
    Date of Patent: June 22, 1982
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Masahiro Yagi, Kohei Kura, Ichiro Shirahase
  • Bis-piperidine compounds
    Patent number: 4336373
    Abstract: Bis(2-hydroxymethyl-3,4,5-trihydroxypiperidine-1-yl-propenyl) compounds and their acid addition salts are antihyperglycemic agents. Typical examples are 1,4-bis[3-(2-hydroxymethyl-3,4,5-trihydroxypiperidin-1-yl)prop-2-enyl] benzene and 1,3-bis-{4-[3-(2-hydroxymethyl-3,4,5-trihydroxy-piperidin-1-yl)prop-2-enyl ]phenoxy}propane.
    Type: Grant
    Filed: March 26, 1981
    Date of Patent: June 22, 1982
    Assignee: Nippon Shinyaku Company, Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Masahiro Yagi, Kohei Kura, Ichiro Shirahase
  • Process for the preparation of 2-hydroxymethyl-3,4,5-trihydroxy piperidine
    Patent number: 4198481
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxy piperidine, or moranoline, is prepared by culturing a moranoline-producing strain of microorganism of the genus Streptomyces in an appropriate culture medium and thereafter isolating moranoline from the culture medium.
    Type: Grant
    Filed: November 15, 1978
    Date of Patent: April 15, 1980
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoji Ezure, Yoshiaki Yoshikuni, Masahiro Yagi
  • Antihyperglycemic N-alkyl-3,4,5-trihydroxy-2-piperidine methanol
    Patent number: 4182767
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxy-N-alkylpiperidines and their acid addition salts are antihyperglycemic agents. A typical example is 2-hydroxymethyl-3,4,5-trihydroxy-N-methylpiperidine.
    Type: Grant
    Filed: May 10, 1978
    Date of Patent: January 8, 1980
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Masahiro Yagi, Ichiro Shirahase
  • Process for the isolation of 2-hydroxymethyl-3,4,5-trihydroxypiperidine from plant material
    Patent number: 4137231
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxypiperidine is obtained from the mulberry plant through extraction, optionally with further purification through ion exchange or chromatographic treatment.
    Type: Grant
    Filed: December 20, 1976
    Date of Patent: January 30, 1979
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Hiroshi Enomoto, Yoshiaki Yoshikuni, Tatsuhiko Kono, Masahiro Yagi
  • Method and composition for reducing blood glucose levels
    Patent number: 4065562
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxypiperidine possesses antidiabetic and lipid biosynthesis inhibitory properties. The use of the compound for such indications and pharmaceutical compositions adapted to this use are described.
    Type: Grant
    Filed: December 20, 1976
    Date of Patent: December 27, 1977
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Katsuya Ohata, Hiroshi Enomoto, Yoshiaki Yoshikuni, Tatsuhiko Kono, Masahiro Yagi
  • Method and composition for reducing blood glucose levels
    Patent number: RE30886
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxypiperidine possesses antidiabetic and lipid biosynthesis inhibitory properties. The use of the compound for such indications and pharmaceutical compositions adapted to this use are described.
    Type: Grant
    Filed: December 15, 1978
    Date of Patent: March 23, 1982
    Assignee: Nippon Shinyaku Company Ltd.
    Inventors: Katsuya Ohata, Hiroshi Enomoto, Yoshiaki Yoshikuni, Tatsuhiko Kono, Masahiro Yagi