Patents by Inventor Masahisa Shimpo

Masahisa Shimpo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adeno-associated virus-mediated delivery of angiogenic factors
    Publication number: 20070128163
    Abstract: The use of recombinant adeno-associated virus (rAAV) virions for delivery of genes encoding angiogenic factors to muscle tissue is disclosed. The invention describes such methods of delivery and also describes methods for treating an ischemic condition such as myocardial ischemia. The methods include direct delivery of rAAV virions to a muscle via intramuscular injection and indirect delivery to a muscle via an injection into a blood vessel supplying blood to the muscle. The invention provides for sustained expression of the rAAV virion-delivered angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic effect, namely an increase in new blood vessel formation resulting in an increase in blood flow to the ischemic muscle tissue.
    Type: Application
    Filed: May 26, 2006
    Publication date: June 7, 2007
    Inventors: Keiya Ozawa, Masahisa Shimpo, Uichi Ikeda, Yoshikazu Maeda, Kazuyuki Shimada
  • Methods for treating and preventing vascular disease
    Publication number: 20060210541
    Abstract: Methods for treating and/or preventing vascular disease are disclosed. The methods use gene delivery techniques to deliver nucleic acid molecules encoding anti-inflammatory cytokines to a subject.
    Type: Application
    Filed: May 26, 2006
    Publication date: September 21, 2006
    Inventors: Uichi Ikeda, Tohru Yoshioka, Yoshikazu Maeda, Masahisa Shimpo, Kazuyuki Shimada, Keiya Ozawa, Tatsuya Nomoto, Takashi Okada, Hiroaki Mizukami
  • Methods for treating and preventing vascular disease
    Publication number: 20040142893
    Abstract: Methods for treating and/or preventing vascular disease are disclosed. The methods use gene delivery techniques to deliver nucleic acid molecules encoding anti-inflammatory cytokines to a subject.
    Type: Application
    Filed: October 20, 2003
    Publication date: July 22, 2004
    Inventors: Uichi Ikeda, Tohru Yoshioka, Yoshikazu Maeda, Masahisa Shimpo, Kazuyuki Shimada, Keiya Ozawa, Tatsuya Nomoto, Takashi Okada, Hiroaki Mizukami
  • Adeno-associated virus-mediated delivery of angiogenic factors
    Publication number: 20020111324
    Abstract: The use of recombinant adeno-associated virus (rAAV) virions for delivery of genes encoding angiogenic factors to muscle tissue is disclosed. The invention describes such methods of delivery and also describes methods for treating an ischemic condition such as myocardial ischemia. The methods include direct delivery of rAAV virions to a muscle via intramuscular injection and indirect delivery to a muscle via an injection into a blood vessel supplying blood to the muscle. The invention provides for sustained expression of the rAAV virion-delivered angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic effect, namely an increase in new blood vessel formation resulting in an increase in blood flow to the ischemic muscle tissue.
    Type: Application
    Filed: August 17, 2001
    Publication date: August 15, 2002
    Inventors: Keiya Ozawa, Masahisa Shimpo, Uichi Ikeda, Yoshikazu Maeda, Kazuyuki Shimada