Abstract: A method of direct transdifferentiation of somatic cells into other somatic cells may be convenient and still have good reproducibility, excellent production efficiency, and short performed time. Methods for direct transdifferentiation of somatic cells into other somatic cells may include: (a) introducing a GLIS family gene, a mutated GLIS family gene or a gene product thereof into somatic cells; and (b) culturing the gene-introduced somatic cells in a culture medium containing a component that induces differentiation of the somatic cells or precursor cells of the somatic cells into other somatic cells.

Abstract: A method for producing pancreatic endocrine cells, including introducing (A), (B), (C), or (D) into somatic cells: (A) mutated GLIS1 gene having ?85%-sequence-identity to base sequence of SEQ ID NO: 1 or 2 or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, Pdx1 gene or gene product(s) thereof, and MafA gene or gene product(s) thereof, (B) mutated GLIS1 gene having ?85%-sequence-identity to base sequence of SEQ ID NO: 1 or 2 or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, and Pdx1 gene or gene product(s) thereof. (C) GLIS1 gene or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, Pdx1 gene or gene product(s) thereof, and MafA gene or gene product(s) thereof, and (D) mutated GLIS1 gene having ?85%-sequence-identity to base sequence of SEQ ID NO: 1 or 2 or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, and MafA gene or gene product(s) thereof.

Abstract: A method for producing pancreatic endocrine cells, including introducing (A), (B), (C), or (D) into somatic cells: (A) mutated GLIS1 gene having 85%-sequence-identity to base sequence of SEQ ID NO: 1 or 2 or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, Pdx1 gene or gene product(s) thereof, and MafA gene or gene product(s) thereof; (B) mutated GLIS1 gene having 85%-sequence-identity to base sequence of SEQ ID NO: 1 or 2 or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, and Pdx1 gene or gene product(s) thereof (C) GLIS1 gene or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, Pdx1 gene or gene product(s) thereof, and MafA gene or gene product(s) thereof and (D) mutated GLIS1 gene having 85%-sequence-identity to base sequence of SEQ ID NO: 1 or 2 or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, and MafA gene or gene product(s) thereof.

Abstract: A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into somatic cells.

Abstract: A method for producing pancreatic endocrine cells, including introducing (A), (B), (C), or (D) is provided. The pancreatic endocrine cells are produced without undergoing an iPS cell stage. The mutated GLIS1 gene having a sequence identity of 85% or more to a base sequence as set forth in SEQ ID NO: 1 or one or more gene products thereof in (A), (B), or (D) is a mutated GLIS1 gene having at least one of (i) addition of any base(s) to 5?-terminus of the mutated GLIS1 gene having sequence identity of 85% or more to the base sequence as set forth in SEQ ID NO: 1 and (ii) addition of any base(s) to 3?-terminus of the mutated GLIS1 gene having sequence identity of 85% or more to the base sequence as set forth in SEQ ID NO: 1.

Abstract: A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into somatic cells.

Abstract: A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into somatic cells.

Abstract: A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into somatic cells.

Abstract: A method for producing pancreatic endocrine cells, including introducing (A), (B), (C), or (D) into somatic cells: (A) mutated GLIS1 gene having 85%-sequence-identity to base sequence of SEQ ID NO: 1 or 2 or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, Pdx1 gene or gene product(s) thereof, and MafA gene or gene product(s) thereof; (B) mutated GLIS1 gene having 85%-sequence-identity to base sequence of SEQ ID NO: 1 or 2 or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, and Pdx1 gene or gene product(s) thereof (C) GLIS1 gene or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, Pdx1 gene or gene product(s) thereof, and MafA gene or gene product(s) thereof and (D) mutated GLIS1 gene having 85%-sequence-identity to base sequence of SEQ ID NO: 1 or 2 or gene product(s) thereof, Neurogenin3 gene or gene product(s) thereof, and MafA gene or gene product(s) thereof.

Abstract: A method for producing pancreatic endocrine cells, the method including introducing one or more genes of a GLIS family or one or more gene products thereof and a Neurogenin3 gene or one or more gene products thereof into somatic cells.

Abstract: An object of the present invention is to provide a technique that can facilitate setting of an object, such as a favorite team. An information output device includes a database that associates and stores a region on a map and a sport team related to the region, a position acquisition unit that acquires a position of a self-vehicle, and a favorite team setting processing unit that sets a favorite team from among sport teams. Moreover, the information output device includes a determination processing unit that specifies the region corresponding to the self-vehicle position acquired by the position acquisition unit and determines the sport team associated with the specified region in the database as an object to be set by the favorite team setting processing unit or a candidate for the object.

Abstract: Methods and compositions are provided for stimulating insulin production, increasing beta cell mass, or decreasing beta cell loss in a subject. For example, methods of the embodiments can comprise administration of a corticotropin-releasing factor (CRF)1 receptor agonist and a CRF2 receptor agonist. Also provided are pharmaceutical compositions comprising a selective CRF1 receptor agonist and a selective CRF2 receptor agonist.

Abstract: An object of the present invention is to provide a technique that can facilitate setting of an object, such as a favorite team. An information output device includes a database that associates and stores a region on a map and a sport team related to the region, a position acquisition unit that acquires a position of a self-vehicle, and a favorite team setting processing unit that sets a favorite team from among sport teams. Moreover, the information output device includes a determination processing unit that specifies the region corresponding to the self-vehicle position acquired by the position acquisition unit and determines the sport team associated with the specified region in the database as an object to be set by the favorite team setting processing unit or a candidate for the object.

Abstract: There is provided a device that receives a broadcast providing a data distribution service from a broadcast station, registers data related to facilities acquired through the data distribution service in a primary database, extracts from the primary database data related to facilities near the position of the host vehicle every time a host vehicle has run a predetermined distance, registers the extracted data in a secondary database, and presents data for presentation extracted from the secondary database to a user.

Abstract: A mold for producing a hollow thermoplastic resin molded article includes a set of female and male mold members and a gas passage provided in at least one of the mold members which opens directly onto a surface of the mold member. Alternatively, a gas introducing member for introducing gas into a cavity may be provided in communication with the gas passage such that the tip of the gas introducing member does not protrude into the cavity of the mold. A lagging material, such as an insulating material or a local heater is preferably provided in the area of the mold adjacent the gas passage or gas introducing member. A method of producing a thermoplastic resin molded article using a mold of this nature is also disclosed.

Abstract: A multilayer molded article constitutes a resin body and a skin material which covers a part of the surface of the resin body so that an edge part of the skin material present on the surface of the resin body is placed in a groove formed on the surface of the resin body. The article is produced by providing an unclosed mold having a lower mold having at least one pin for fixing the edge part of the skin material at a position where the edge part of the skin material is placed and an upper mold having a kick for forming the groove, placing the skin material on the lower mold and fixing the edge part of the skin material with the pin, supplying a mass of resin melt between the skin material and the lower mold, and closing the upper and lower molds to form the multilayer molded article.

Abstract: The present invention relates to a metal mold for producing a synthetic resin molded product in a compression-molding method, which is comprises a pair of male and female molds which are allowed to mutually slide over a contact face, with the outer circumferential face of the male mold and the inner circumferential face of the female mold serving as sliding portions at the time of mold-clamping, characterized in that either the male mold or the female mold or both of the molds is constituted by a mold main body and a sliding member. The sliding member forms a portion of the metal mold over the entire sliding portions or on a portion thereof, and is removably attached to the mold main body. The same metal mold may be used for production of a non-laminated synthetic resin molded product and a laminated product having the same design by replacing only the sliding member, without the need for using different molding devices corresponding to the respective production processes.

Abstract: The present invention relates to a metal mold for producing a synthetic resin molded product in a compression-molding method.

Abstract: A multilayer molded article comprises a resin body and a skin material which covers a part of the surface of the resin body so that an edge part of the skin material present on the surface of the resin body is placed in a groove formed on the surface of the resin body. The article is produced by providing an unclosed mold comprising a lower mold having at least one pin for fixing the edge part of the skin material at a position where the edge part of the skin material is placed and an upper mold having a kick for forming the groove, placing the skin material on the lower mold and fixing the edge part of the skin material with the pin, supplying a mass of resin melt between the skin material and the lower mold, and closing the upper and lower molds to form the multilayer molded article.

Abstract: An instrument panel is provided having a skin material integrally bonded to the surface of a thermoplastic resin core material. The panel is obtained by feeding the skin material to a cavity between a pair of male and female molds having been designed so as to give a desired instrument panel shape, and press-molding a molten thermoplastic resin after or while feeding the molten thermoplastic resin to the cavity between the skin material and the male mold or the female mold. Brackets are formed integrally, by press-molding, with the core material resin on opposing end portions and at a back portion of the instrument panel.