Patents by Inventor Masaji Sezaki
Masaji Sezaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5278052Abstract: Benanomicin A and Benanomicin B are fermentatively produced by the cultivation of a new microorganism Actinomadura spadix, designated as MH193-16F4 strain.Type: GrantFiled: June 14, 1991Date of Patent: January 11, 1994Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Takeshi Hara, Masa Hamada, Shinichi Kondo, Masaji Sezaki, Haruo Yamamoto, Shuichi Gomi
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Patent number: 5219754Abstract: This disclosure describes a novel antibiotic designated Vermisporin produced in a microbiological fermentation using, for example, a new strain of Ophiobolus Vermisporus L-8. This novel antibiotic is an active antibacterial, especially anti-anaerobic bacterial agent.Type: GrantFiled: July 3, 1989Date of Patent: June 15, 1993Assignees: Mitsubishi Kasei Corporation, Meiji Seika Kaisha, LimitedInventors: Takashi Mikawa, Noriko Takahashi, Haruyuki Ohkishi, Yoshikazu Sato, Shinji Miyadoh, Masaji Sezaki
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Patent number: 5210097Abstract: A xanthocillin X monomethyl ether derivative represented by the formula (I) ##STR1## wherein R represents an alkyl group, an alkenyl group, an alkoxycarbonyl group, an aralkyl group, an alkyl group substituted with a pyridyl group or a halogen atom, an aralkyl group substituted with an alkyl group or a halogen atom, or an aroyl group, which exerts an intense effect of inhibiting the proliferation of a tumor, in particular, a solid tumor.Type: GrantFiled: May 18, 1990Date of Patent: May 11, 1993Assignee: Meiji Seika Kaisha Ltd.Inventors: Hiroshi Kurihara, Hiromi Watanabe, Masao Koyama, Masaji Sezaki, Tsutomu Tsuruoka, Harumi Fukuyasu, Haruo Yamamoto
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Patent number: 5194617Abstract: 2,3-disubstituted-4-hydroxyquinoline derivatives of the general formula (I): ##STR1## [wherein R.sup.1 represents a hydrogen atom or R.sup.3 CO-- (wherein R.sup.3 is a lower alkyl group); R.sup.2 represents a hydrogen atom, --CH.sub.3 or --C.sub.2 H.sub.5 ; A represents ##STR2## and W represents a hydrogen atom, or 1- 4 halogen atoms or alkyl groups which are substituted at the nucleus and may be the same or different] have a strong antagonistic action on leukotriene D.sub.4.Type: GrantFiled: December 10, 1991Date of Patent: March 16, 1993Assignee: Meiji Seika Kaisha, Ltd.Inventors: Nobuto Minowa, Tomoya Machinami, Takashi Shomura, Masaji Sezaki, Toru Sasaki, Seiji Shibahara, Shigeharu Inouye
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Patent number: 5116815Abstract: A novel substance having anthelmintic activity, the PF 1022 substance, which is produced by cultivating a fungal strain capable of producing the substance and recovering the substance from the culture.Type: GrantFiled: February 6, 1990Date of Patent: May 26, 1992Assignee: Meiji Seika Kaisha Ltd.Inventors: Masayuki Takagi, Tadaaki Okada, Naotoshi Akai, Takashi Yaguchi, Shinji Miyadoh, Takashi Shomura, Toru Sasaki, Masaji Sezaki, Takao Shimizu, Masashi Niida
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Patent number: 5109122Abstract: Two new antibiotics which are now nominated as benanomicin A and benanomicin B, respectively, are fermentatively produced by the cultivation of a new microorganism, designated as MH193-16F4 strain, of Actinomycetes. Benanomicins A and B each show antifungal activity and are useful as a therapeutic antifungal agent. A new compound, dexylosylbenanomicin B is now produced by chemical conversion of benanomicin B, and this semi-synthetic antibiotic also shows antifungal activity and is useful as a therapeutic antifungal agent.Type: GrantFiled: June 14, 1991Date of Patent: April 28, 1992Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Takeshi Hara, Masa Hamada, Shinichi Kondo, Masaji Sezaki, Haruo Yamamoto, Shuichi Gomi
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Patent number: 5055453Abstract: Two new antibiotics which are now nominated as benanomicin A and benanomicin B, respectively, are fermentatively produced by the cultivation of a new microorganism, designated as MH193-16F4 strain, of Actinomycetes. Benanomicins A and B each show antifungal activity and are useful as a therapeutic antifungal agent. A new compound, dexylosylbenanomicin B is now produced by chemical conversion of benanomicin B, and this semi-synthetic antibiotic also shows antifungal activity and is useful as a therapeutic antifungal agent.Type: GrantFiled: October 31, 1988Date of Patent: October 8, 1991Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Takeshi Hara, Masa Hamada, Shinichi Kondo, Masaji Sezaki, Haruo Yamamoto, Shuichi Gomi
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Patent number: 5037993Abstract: Novel substances exhibiting antimicrobial activity and antitumor activity, a process for producing them by cultivating a microorganism belonging to the genus Streptomyces and capable of producing them and derivatives of such substances.Type: GrantFiled: May 8, 1990Date of Patent: August 6, 1991Assignee: Meiji Seika Kaisha Ltd.Inventors: Kazunori Ohba, Masaji Sezaki, Shinichi Kondo, Masao Koyama, Tadashi Nakazawa, Haruo Yamamoto
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Patent number: 5028601Abstract: Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are a hydrogen atom or a lower alkyl group of 1-5 carbon atoms and A is a hydrogen atom or a nucleophilic compound residue or pharmacologically acceptable salts thereof have excellent antibacterial activity against Gram positive and Gram negative microorganisms.Type: GrantFiled: April 21, 1988Date of Patent: July 2, 1991Assignees: Meiji Saika Kaisha, Ltd., Zaidanhojin Biseibutsu Kagaku KenkyukaiInventors: Shinichi Kondo, Takashi Tsuruoka, Katsuyoshi Iwamatsu, Kiyoaki Katano, Satoru Nakabayashi, Hiroko Ogino, Takashi Yoshida, Masaji Sezaki
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Patent number: 5026547Abstract: A novel compound having an intense insecticidal activity and a process for producing the same which comprises culturing a strain belonging to the genus Humicola and isolating the compound from the culture.Type: GrantFiled: November 9, 1989Date of Patent: June 25, 1991Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kei-ichi Imamura, Shuichi Gomi, Michiaki Iwata, Shinji Miyadoh, Masaru Shimura, Takashi Shomura, Masaji Sezaki, Shigeharu Inoye
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Patent number: 4994578Abstract: Novel substances exhibiting antimicrobial activity and antitumor activity, a process for producing them by cultivating a microorganism belonging to the genus Streptomyces and capable of producing them and derivatives of such substances.Type: GrantFiled: April 28, 1989Date of Patent: February 19, 1991Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kazunori Ohba, Hiroomi Watabe, Mieko Nagasawa, Shiro Sakakibara, Takashi Shomura, Masaji Sezaki, Shinichi Kondo, Masao Koyama, Tadashi Nakazawa, Haruo Yamamoto
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Patent number: 4954641Abstract: An antibiotic substance represented by formula (I) ##STR1## or a pharmaceutically acceptable salt thereof, which is produced by cultivating a microorganism belonging to the genus Streptomyces and isolating the substance from the cultured cells.Type: GrantFiled: January 30, 1989Date of Patent: September 4, 1990Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yoshikazu Sato, Hiroomi Watabe, Shigetaka Ishii, Tadashi Nakazawa, Takashi Shomura, Masaji Sezaki, Shinichi Kondo
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Patent number: 4933180Abstract: This disclosure describes a novel antibiotic designated Vermisporin produced in a microbiological fermentation using, for example, a new strain of Ophiobolus Vermisporus L-8. This novel antibiotic is an active antibacterial, especially anti-anaerobic bacterial agent.Type: GrantFiled: February 2, 1988Date of Patent: June 12, 1990Assignees: Mitsubishi Kasei Corporation, Meiji Seika Kaisha, LimitedInventors: Takashi Mikawa, Noriko Takahashi, Haruyuki Ohkishi, Yoshikazu Sato, Shinji Miyadoh, Masaji Sezaki
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Patent number: 4839378Abstract: Fluorophthalimide compounds represented by the following general formula (I): ##STR1## wherein R each stands for an ethyl group or an isopropyl group, are effective for controlling diseases of agricultural plants, especially diseases caused by microorganisms belonging to the genus Rhizoctonia, represented by sheath blight of rice plants, and diseases caused by Basidomycetes.Type: GrantFiled: April 28, 1987Date of Patent: June 13, 1989Assignee: Meiji Seika Kabushiki KaishaInventors: Masao Koyama, Michiaki Iwata, Kunihiko Kurihara, Masaji Sezaki
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Patent number: 4758557Abstract: Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: ##STR1## wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); ##STR2## or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): ##STR3## or an unsubstituted or substituted pyridinium group of a formula (I-3); ##STR4## or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):--S--Het (I-4).Type: GrantFiled: June 9, 1986Date of Patent: July 19, 1988Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takashi Tsuruoka, Katsuyoshi Iwamatsu, Kiyoaki Katano, Hiroko Ogino, Ryoichi Okamoto, Takashi Yoshida, Masaji Sezaki, Fumio Kai, Shigeharu Inoue, Shinichi Kondo
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Patent number: 4548816Abstract: Novel antibiotic SF-2288 is produced by fermentation of an actinomycete belonging to the genus Actinomadura in nutrient medium. Based on its physico-chemical and biological properties, antibiotic SF-2288 possesses an excellent antimicrobial activity against Gram-positive and Gram-negative microorganisms and antiviral activity.Type: GrantFiled: June 21, 1984Date of Patent: October 22, 1985Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yasumitsu Kondo, Takashi Shomura, Junko Yoshida, Kazuo Okano, Masaji Sezaki, Tatsuo Itoh
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Patent number: 4404218Abstract: An antibiotic SF-2103A substance or a salt thereof, and a process for the production thereof are described, and the process comprises cultivating an antibiotic SF-2103A substance-producing strain in a nutrient medium and recovering the desired substance from the culture broth.Type: GrantFiled: August 17, 1981Date of Patent: September 13, 1983Assignee: Meiji Seika Kaisha Ltd.Inventors: Tatsuo Ito, Takashi Shomura, Michio Kojima, Norio Ezaki, Masaji Sezaki, Tomizo Niwa
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Patent number: 4229448Abstract: 5-Substituted picolinic acid derivatives represented by the formula (I): ##STR1## wherein R.sub.1 represents a straight or branched chain halogen-substituted alkyl group having 2 to 6 carbon atoms or a substituted phenyl group having the formula ##STR2## wherein R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group, an N-alkyl-substituted amino group, an acylamino group, an acetyl group, an acyloxy group, a hydroxy group or a halogen-substituted alkyl group or R.sub.3 and R.sub.4, when taken together, represent a polymethylene chain; and R.sub.Type: GrantFiled: March 23, 1979Date of Patent: October 21, 1980Assignee: Meuji Seika Kaisha Ltd.Inventors: Yasuharu Sekizawa, Takashi Tsuruoka, Mitsugu Hachisu, Masaji Sezaki, Masashi Miyamoto, Uichi Shibata, Kazuko Mizutani, Shigeharu Inouye, Takemi Koeda, Keizo Shimomura, Taro Niida