Patents by Inventor Masakatsu Kaneko
Masakatsu Kaneko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6256552Abstract: A method for setting a tool-based working condition in off-line teaching makes it possible to automatically set an optimum tool-based working condition while referring to specifications of a tool and workpiece-based working conditions so that reduced operation time required for the off-line teaching is efficiently realize.Type: GrantFiled: September 2, 1998Date of Patent: July 3, 2001Assignee: Honda Giken Kabushiki KaishaInventors: Shinji Aoki, Masakatsu Kaneko
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Patent number: 6226567Abstract: An off-line teaching apparatus comprises an operation command-receiving means for receiving an operation command inputted via an input/output port from a key input device or a coordinate input device and successively storing the operation command in a buffer; an operation command-reading means for successively reading the operation command stored in the buffer; an operation command-counting means for counting a number of operation commands stored in the buffer; and a confirmation sound-generating means for generating confirmation sound upon receipt of the operation command by the operation command-receiving means when a counted value obtained by the operation command-counting means is not less than a predetermined number. Accordingly, the operator can be informed, in real time, of the fact that the system responds to the input of the operation command from the operator. Thus, it is possible to improve the operability of the off-line teaching.Type: GrantFiled: August 31, 1998Date of Patent: May 1, 2001Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Masakatsu Kaneko, Shinji Aoki
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Patent number: 5807837Abstract: A composition and method of treatment or prophylaxis of a viral infection in a mammal, such as a human, are provided. The compounds in the composition and which are administered in the method, are oligodeoxyribonucleic acid derivatives of the formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups, and anthraquinonyl groups; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group or an aryl group; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or >NH; Y.sub.2 is oxygen, sulfur, >NH, alkylene or phenylene; X is an alkylene group; m and n are each 0 to 10; and B is an oligodeoxyribonucleotide of a chain length of 3 to 9, or salts thereof.Type: GrantFiled: June 1, 1995Date of Patent: September 15, 1998Assignee: Sankyo Company, LimitedInventors: Hidehiko Furukawa, Kenji Momota, Hitoshi Hotoda, Makoto Koizumi, Masakatsu Kaneko
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Patent number: 5760042Abstract: New griseolic acid derivatives have various groups attached to the sugar part in place of the adenine group of griseolic acid itself. These groups are all purine derivatives or ring-opened purine analogs. The compounds are useful as inhibitors of phosphodiesterases.Type: GrantFiled: October 6, 1994Date of Patent: June 2, 1998Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Yoshinobu Murofushi, Misako Kimura, Mitsuo Yamazaki, Yasuteru Iijima
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Patent number: 5691319Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen atoms, optionally substituted alkanoyl groups and alkenylcarbonyl groups, PROVIDED THAT at least one of R.sup.1, R.sup.2 and R.sup.3 represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R.sup.4 and R.sup.5 represents a hydrogen atom and the other represents a cyano group; have valuable anti-tumor activity.Type: GrantFiled: June 5, 1995Date of Patent: November 25, 1997Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Hitoshi Hotoda, Tomoyuki Shibata, Tomowo Kobayashi, Yoshihiro Mitsuhashi, Akira Matsuda, Takuma Sasaki
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Patent number: 5674856Abstract: Compounds for the treatment or prophylaxis of a viral infection in a mammal, which may be human, are provided. The compounds are oligodeoxyribonucleic acid derivatives, and a novel route to such compounds is also provided together with intermediates of more general utility.The active compounds are of the general formula (1): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms, alkyl groups, aryl groups as defined, and anthraquinonyl groups as defined; Z is carbon or silicon; or R.sub.2, R.sub.3 and Z together represent fluorenyl or xanthenyl; R.sub.4 is a hydrogen atom, an alkyl group as defined, an aryl group as defined; Y.sub.1, Y.sub.3 and Y.sub.4 are oxygen, sulfur or >NH; Y.sub.2 is oxygen, sulfur, >NH, alkylene or phenylene; X is alkylene group as defined; m and n are 0 to 10; and B is an oligodeoxyribonucleotide of chain length 3 to 9; or salts thereof.Type: GrantFiled: February 23, 1995Date of Patent: October 7, 1997Assignee: Sankyo Company, LimitedInventors: Hidehiko Furukawa, Kenji Momota, Hitoshi Hotoda, Makoto Koizumi, Masakatsu Kaneko
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Patent number: 5616600Abstract: A compound of the formula (I) is provided ##STR1## wherein A represents a group of the formula: ##STR2## R.sup.1 and R.sup.2 are independently hydrogen, halogen or a group of the formula --OR.sup.9 ; R.sup.9 is hydrogen, alkyl, alkylsulfonyl, haloalkylsulfonyl, arylsulfonyl or a hydroxy-protecting group; R.sup.3 and R.sup.4 are independently carbamoyl or carboxy; R.sup.5 and R.sup.6 both represent hydrogen or together represent an extra carbon-carbon bond between the carbon atoms to which they are attached; and Z represents hydrogen or unsubstituted or substituted hydroxy; or a pharmaceutically acceptable salt or ester thereof. The compounds are useful as inhibitors of phosphodiesterases.Type: GrantFiled: May 9, 1995Date of Patent: April 1, 1997Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Yoshinobu Murofushi, Misako Kimura, Mitsuo Yamazaki, Yasuteru Iijima
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Patent number: 5556975Abstract: A compound of the formula (I) is provided ##STR1## wherein A represents a group of the formula: ##STR2## R.sup.1 and R.sup.2 are independently hydrogen, halogen or a group of the formula --OR.sup.9 ; R.sup.3 and R.sup.4 are independently carbamoyl or carboxy; R.sup.5 and R.sup.a both represent hydrogen or together represent an extra carbon-carbon bond between the carbon atoms to which they are attached; and R.sup.9 is hydrogen, alkyl, alkysulfonyl, haloalkylsulfonyl, arylsulfonyl or a hydroxy-protecting group; or a pharmaceutically acceptable salt or ester thereof. The compounds are useful as inhibitors of phosphodiesterases.Type: GrantFiled: May 9, 1995Date of Patent: September 17, 1996Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Yoshinobu Murofushi, Misako Kimura, Mitsuo Yamazaki, Yasuteru Iijima
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Patent number: 5532369Abstract: A compound of the formula (I) is provided ##STR1## wherein A represents a group of the formula: ##STR2## R.sup.1 and R.sup.2 are independently hydrogen, halogen or a group of the formula --OR.sup.9 ; R.sup.9 is hydrogen, alkyl, alkylsulfonyl, haloalkylsulfonyl, arylsulfonyl or a hydroxy-protecting group; R.sup.3 and R.sup.4 are independently carbamoyl or carboxy; R.sup.5 and R.sup.6 both represent hydrogen or together represent an extra carbon-carbon bond between the carbon atoms to which they are attached; and W represents an alkoxy or aralkoxy; or a pharmaceutically acceptable salt or ester thereof. The compounds are useful as inhibitors of phosphodiesterases.Type: GrantFiled: May 9, 1995Date of Patent: July 2, 1996Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Yoshinobu Murofushi, Misako Kimura, Mitsuo Yamazaki, Yasuteru Iijima
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Patent number: 5498819Abstract: New griseolic acid derivatives have various groups attached to the sugar part in place of the adenine group of griseolic acid itself. These groups are all purine derivatives or ring-opened purine analogs. The compounds are useful as inhibitors of phosphodiesterases.Type: GrantFiled: September 30, 1993Date of Patent: March 12, 1996Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Yoshinobu Murofushi, Misako Kimura, Mitsuo Yamazaki, Yasuteru Iijima
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Patent number: 5391564Abstract: Rhizoxin and rhizoxin-2-ene derivatives of formula (I): ##STR1## in which: n is 1 to 25: A is an extra bond or oxygen, X is oxygen, sulfur, nitrogen or carbonyl; and R is hydrogen, carboxylic acyl having from 1 to 25 carbon atoms, alkoxycarbonyl group having from 2 to 26 carbon atoms, phosphono, alkylphosphono group in which the alkyl part has from 1 to 25 carbon atoms, dialkylphosphono group in which each alkyl part has from 1 to 25 carbon atoms, alkyl group having from 1 to 25 carbon atoms, aralkyl, cycloalkyl, heterocyclic, alkylthio group in which the alkyl part has from 1 to 25 carbon atoms, aralkylthio, or heterocyclylthio, or when X represents a nitrogen atom, R is R.sup.1 and R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, acyl, alkoxycarbonyl, phosphono, alkylphosphono or dialkylphosphono have valuable anti-tumor activity. They may be prepared by acylation of rhizoxin or rhizoxin-2-ene.Type: GrantFiled: February 14, 1994Date of Patent: February 21, 1995Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Makoto Kamokari, Tomowo Kobayashi, Kazuhiko Sasagawa
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Patent number: 5352689Abstract: Rhizoxin and rhizoxin-2-ene derivatives of formula ##STR1## in which: n is 1 to 25; A is an extra bond or oxygen, X is oxygen, sulfur, nitrogen or carbonyl; and R is hydrogen, carboxylic acyl having from 1 to 25 carbon atoms, alkoxycarbonyl group having from 2 to 26 carbon atoms, phosphono, alkylphosphono group in which the alkyl part has from 1 to 25 carbon atoms, dialkylphosphono group in which each alkyl part has from 1 to 25 carbon atoms, alkyl group having from 1 to 25 carbon atoms, aralkyl, cycloalkyl, heterocyclic, alkylthio group in which the alkyl part has from 1 to 25 carbon atoms, aralkylthio, or heterocyclylthio, or when X represents a nitrogen atom, R is R.sup.1 and R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, acyl, alkoxycarbonyl, phosphono, alkylphosphono or dialkylphosphono, have valuable anti-tumor activity. They may be prepared by acylation of rhizoxin or rhizoxin-2-ene.Type: GrantFiled: September 27, 1993Date of Patent: October 4, 1994Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Makoto Kamokari, Tomowo Kobayashi, Kazuhiko Sasagawa
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Patent number: 5341458Abstract: In a method and system for generating teaching data for robots, a plurality of virtual target points are disposed in the vicinity of each of target points allowable on design, where a tool center point of a robot is to be positioned. The virtual target points and the original target point are combined into "target points taken in a broad sense". Each of the target points taken in the broad sense is given as a point which has been confirmed as a tool-attainable point on an off-line teaching apparatus. When a necessary correction is made on-line to teaching data generated by the off-line teaching apparatus, including as data the target points taken in the broad sense, an operator can select a suitable point from the target points taken in the broad sense and carry out a process of correcting the teaching data, regarding the suitable point as being a starting point.Type: GrantFiled: September 10, 1992Date of Patent: August 23, 1994Assignee: Honda Giken Kogyo Kabushiki KaishaInventors: Masakatsu Kaneko, Hidetaka Nosse, Katsumi Takeishi
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Patent number: 4783532Abstract: Griseolic acid and dihydrodesoxygriseolic acid derivatives having an alkyl or aralkyl group as a substituent on the amino group at the 6-position are prepared by reacting the unsubstituted compound with a compound R.sup.7 -X (where R.sup.7 is alkyl or aralkyl and X is halogen or sulfonyloxy). The group first substitutes and quaternizes the 1-nitrogen atom. The compound is then subjected to an appropriate combination of temperature and pH to cause ring cleavage, rearrangement and ring closure involving the 6-amino group and this quaternized 1-nitrogen to give a 6-alkylamino or 6-aralkylamino derivative.Type: GrantFiled: April 25, 1986Date of Patent: November 8, 1988Assignee: Sankyo Company LimitedInventors: Masakatsu Kaneko, Misako Kimura, Yoshinobu Murofushi
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Patent number: 4634706Abstract: Griseolic acid derivatives of formula (I): ##STR1## wherein A represents: ##STR2## have enzyme-inhibitory activity, especially against cAMP PDE and cGMP PDE. When formulated as compositions with appropriate carriers or diluents, they may be used for the treatment of a variety of organic disorders and show toxicities less than griseolic acid itself.Type: GrantFiled: October 25, 1984Date of Patent: January 6, 1987Assignee: Sankyo Company LimitedInventors: Masakatsu Kaneko, Misako Kimura, Yoshinobu Murofushi, Mitsuo Yamazaki, Nobuyoshi Iwata, Fumio Nakagawa
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Patent number: 4248999Abstract: 5-Fluorouracil compounds having a glycoside substituent connected to the 5-fluorouracil nucleus through a bridging oxygen atom; and having anti-tumor activity.Type: GrantFiled: October 31, 1977Date of Patent: February 3, 1981Assignee: Sankyo Company LimitedInventors: Tsuneo Baba, Masakatsu Kaneko, Bunji Shimizu, Masao Arakawa
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Patent number: 4126745Abstract: A compound having the formula ##STR1## wherein Y represents a 2-carboxyethylthio group or a trifluoromethylthio group and a nontoxic pharmaceutically acceptable salt thereof are useful as antibacterial agents. They may be prepared by (a) reacting a compound having the formula ##STR2## wherein X.sub.1 represents a halogen atom with a compound having the formulaY -- Hwherein Y has the same meaning as defined above, or (b) reacting a compound having the formula ##STR3## wherein R represents a protective group for the carboxyl group with a compound having the formulaY -- CH.sub.2 COX.sub.2wherein X.sub.2 represents a halogen atom and Y has the same meaning as defined above and removing the protective group for the carboxyl group from the resulting product, or (c) reacting a compound having the formula ##STR4## wherein A represents an acetoxy group or a carbamoyloxy group and Y has the same meaning as defined above with 5-mercapto-1-methyl-1H-tetrazole or its alkali metal salt.Type: GrantFiled: April 13, 1976Date of Patent: November 21, 1978Assignee: Sankyo Company LimitedInventors: Hideo Nakao, Hiroaki Yanagisawa, Bunji Shimizu, Masakatsu Kaneko, Mitsuo Nagano, Shinichi Sugawara
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Patent number: 4051129Abstract: A process for preparing 7.alpha.-methoxycephalosporin compounds which comprises reacting a salt of a 7.beta.-benzylideneamino-7.alpha.-methoxy-3-cephem-4-carboxylic acid with a hydrazine compound to give a salt of a 7.beta.-amino-7.alpha.-methoxy-3-cephem-4-carboxylic acid and reacting the latter compound with a carboxylic acid or its reactive derivative. The products are useful as antibacterial agents.Type: GrantFiled: November 11, 1975Date of Patent: September 27, 1977Assignee: Sankyo Company LimitedInventors: Bunji Shimizu, Akio Saito, Masakatsu Kaneko, Hiroaki Yanagisawa, Hideo Nakao
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Patent number: 4007177Abstract: A compound of the formula ##STR1## wherein A represents acetoxy group, carbamoyloxy group or (1-metyl-1H-tetrazol-5-yl)thio group and Y represents propargylthio group, azidomethylthio group, 2-hydroxyethylthio group, 3-isoxazolyloxy group, 3-isoxazolylthio group, methylsulfonyl group, ethylsulfonyl group, 2-cyanoethyl-sulfonyl group or sydnon-3-yl group and nontoxic pharmaceutically acceptable salts thereof are prepared by a process which comprises reacting a compound of the formula ##STR2## wherein R represents a protective group for a carboxyl group and A has the same meaning as defined above with a carboxylic acid of the formulaY - CH.sub.2 COOHwherein Y has the same meaning as defined above or a reactive derivative thereof to give a compound having the formula ##STR3## wherein A, R and Y have the same meanings as defined above and removing the protective group for the carboxyl group from said compound.The compounds are antibacterial agents.Type: GrantFiled: November 14, 1974Date of Patent: February 8, 1977Assignee: Sankyo Company LimitedInventors: Hideo Nakao, Hiroaki Yanagisawa, Mitsuo Nagano, Bunji Shimizu, Masakatsu Kaneko, Shinichi Sugawara