Patents by Inventor Masakatsu Ozeki

Masakatsu Ozeki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5496815
    Abstract: Thiazine derivatives of the formula [I]: ##STR1## wherein R.sup.1, R.sup.2, R.sup.4 and R.sup.5 are each hydrogen atom; R.sup.3 is hydrogen atom or a halogen atom; X is sulfur atom; R.sup.6 is naphthyl, a sulfur-containing monoheterocyclic group or a substituted phenyl; Z.sup.1 is two hydrogen atoms; Z.sup.2 is oxygen atom; A is a lower alkylene; R.sup.7 and R.sup.8 are the same or different and are each i) hydrogen atom, ii) a lower alkyl, iii) a lower alkenyl, iv) a lower alkynyl, or v) a lower alkyl which is substituted by a substituted phenyl, or both form together with the adjacent nitrogen atom a nitrogen-containing monoheterocyclic group; except for the compound [I] wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each hydrogen atom, X is sulfur atom, R.sup.6 is a halogenophenyl, Z.sup.1 is two hydrogen atoms, Z.sup.2 is oxygen atom, A is a lower alkylene, R.sup.7 and R.sup.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: March 5, 1996
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Masakatsu Ozeki, Shin-ichi Kodato, Kousuke Yasuda, Yukitsuka Kudo, Kayoko Maeda
  • Patent number: 5281592
    Abstract: Thiazine derivatives of the formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 are both H or form a naphthalene ring together with the benzene ring; R.sup.3 and R.sup.4 are both H, or one of them is halogen and another is H; X is S or O; R.sup.5 and R.sup.6 are each i) H, ii) lower alkyl, iii) cycloalkyl, iv) substituted phenyl, v) naphthyl, vi) lower alkyl which is substituted by substituted or unsubstituted phenyl, or vii) S-containing heterocyclic group; one of Z.sup.1 and Z.sup.2 is O and another is H.sub.2 ; A is lower alkylene; R.sup.7 and R.sup.8 are each i) H, ii) lower alkyl, iii) lower alkenyl, iv) lower alkynyl, or v) lower alkyl which is substituted by substituted or unsubstituted phenyl, or both form together N-containing heterocyclic group; provided that when both of R.sup.1 and R.sup.2 are H, Z.sup.2 is O and either one of R.sup.5 and R.sup.
    Type: Grant
    Filed: September 23, 1992
    Date of Patent: January 25, 1994
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Masakatsu Ozeki, Shin-ichi Kodato, Kousuke Yasuda, Yukitsuka Kudo, Kayoko Maeda
  • Patent number: 5252589
    Abstract: There is disclosed a benzocycloheptene compound of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a halogen atom or a lower alkoxy group, R.sup.2 and R.sup.3 are independently selected from hydrogen atom, a lower alkyl group and a lower alkenyl group, or R.sup.2 and R.sup.3 combine together with adjacent nitrogen atom to form a heteromonocyclic group, or a pharmaceutically acceptable salt thereof, which has an excellent inhibitory activity against contraction of urinary bladder.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: October 12, 1993
    Assignee: Tanabe Seikayu Co., Ltd.
    Inventors: Masakatsu Ozeki, Kosuke Yasuda, Masamichi Morimoto, Tohru Ishizuka, Kunio Nosaka
  • Patent number: 5246929
    Abstract: Thiazine (or oxazine) derivatives of the formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 are both H or form a naphthalene ring together with the benzene ring; R.sup.3 and R.sup.4 are both H, or one of them is halogen and another is H; X is S or O; R.sup.5 and R.sup.6 are each i) H, ii) lower alkyl, iii) cycloalkyl, iv) substituted phenyl, v) naphthyl, vi) lower alkyl which is substituted by substituted or unsubstituted phenyl, or vii) S-containing heterocyclic group; one of Z.sup.1 and Z.sup.2 is O and another is H.sub.2 ; A is lower alkylene; R.sup.7 and R.sup.8 are each i) H, ii) lower alkyl, iii) lower alkenyl, iv) lower alkynyl, or v) lower alkyl which is substituted by substituted or unsubstituted phenyl, or both form together N-containing heterocyclic group; provided that when both of R.sup.1 and R.sup.2 are H, Z.sup.2 is O and either one of R.sup.5 and R.sup.
    Type: Grant
    Filed: January 31, 1991
    Date of Patent: September 21, 1993
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Masakatsu Ozeki, Shin-ichi Kodato, Kousuke Yasuda, Yukitsuka Kudo, Kayoko Maeda
  • Patent number: 4948900
    Abstract: Novel benzoxazole derivatives of the formula: ##STR1## wherein R is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted cycloalkyl group or a substituted or unsubstituted heterocyclic group; Alk is single bond, a substituted or unsubstituted lower alkylene group, a lower alkenylene group or a lower alkynylene group; the group is a group of the formula: --CH.sub.2 -- or --CH.dbd., and a pharmaceutically acceptable salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: August 14, 1990
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Ikuo Iijima, Masakatsu Ozeki, Kunihito Okumura, Masanori Inamasu
  • Patent number: 4897393
    Abstract: Novel benzoxazole derivative of the formula: ##STR1## wherein R is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted cycloalkyl group or a substituted or unsubstituted heterocyclic group; Alk is single bond, a substituted or unsubstituted lower alkylene group, a lower alkenylene group or a lower alkynylene group; the group ##STR2## is a group of the formula: --CH.sub.2 -- or --CH.dbd., and a pharmaceutically aceptable salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: January 30, 1990
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Ikuo Iijima, Masakatsu Ozeki, Kunihito Okumura, Masanori Inamasu
  • Patent number: 4882340
    Abstract: A novel benzofuran derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkoxy group or a halogen atom, one of R.sup.2 and R.sup.3 is a lower alkyl group and the other is a lower alkyl group or a phenyl-lower alkyl group, or R.sup.2 and R.sup.3 combine together with adjacent nitrogen atom to form a heteromonocyclic group, Ring A is a substituted or unsubstituted phenyl group, Y is oxygen atom or sulfur atom and n is an integer of 2 or 3, or a pharmaceutically acceptable salt thereof is disclosed.The compound (I) or a pharmaceutically acceptable salt thereof has a potent inhibitory activity against reflective contractions of urinary bladder.
    Type: Grant
    Filed: September 2, 1988
    Date of Patent: November 21, 1989
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Ikuo Iijima, Masakatsu Ozeki, Yutaka Saiga, Tohru Ishizuka, Kunio Nosaka
  • Patent number: 4829067
    Abstract: Novel benzo-furan(or -thiophene) derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl-lower alkyl group or a substituted or unsubstituted phenyl group, R.sup.2 is hydrogen atom, a lower alkyl group, an acyl group or phenyl group, R.sup.3 is hydrogen atom, a halogen atom, nitro group, a lower alkoxy group, amino group or an acylamino group, R.sup.4 is a group of the formula: ##STR2## A is a lower alkylene group optionally substituted with hydroxy group, B is single bond or a lower alkylene group, one of R.sup.5 and R.sup.6 is hydrogen atom or a lower alkyl group and the other is a lower alkyl group or a phenyl-lower alkyl group, or R.sup.5 and R.sup.6 combine together with adjacent nitrogen atom to form a heteromonocyclic group, R.sup.7 is a lower alkyl group, X is oxygen atom or sulfur atom, Y is oxygen atom, imino group, a lower alkylimino group or a phenyl-lower alkylimino group and a salt thereof are disclosed.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: May 9, 1989
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Ikuo Iijima, Masakatsu Ozeki, Yutaka Saiga, Tohru Ishizuka, Kunio Nosaka
  • Patent number: 4824833
    Abstract: Novel benzoxazine derivative of the formula: ##STR1## wherein R.sup.1 is phenyl group or a substituted thiazolyl group; R.sup.2 is hydrogen atom or a lower alkyl group; Q is single bond or a lower alkylene group, or a salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: April 25, 1989
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Ikuo Iijima, Masakatsu Ozeki, Kunihito Okumura, Masanori Inamasu
  • Patent number: 4241053
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is lower alkoxy, lower alkoxy-methoxy or 2-hydroxy-ethoxy, R.sup.2 is aldo-pentofuranosyl, aldo-pentopyranosyl, aldohexopyranosyl or O-aldo-hexopyranosyl-(1.fwdarw.4)-aldo-hexopyranosyl, and A is straight or branched alkylene of one to four carbon atoms, said alkylene being substituted with from 0 to at least one lower alkoxy group, is disclosed. A new intermediate used in the preparation of this compound is also disclosed. The end products are useful for inhibiting the growth of malignant tumor cells in warm-blooded animals; especially Leukemia and Ejrlich ascites carcinoma. Effectiveness on human beings has not yet been demonstrated.
    Type: Grant
    Filed: August 14, 1979
    Date of Patent: December 23, 1980
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kenji Tsujihara, Masakatsu Ozeki, Yoshihisa Arai
  • Patent number: 4241052
    Abstract: A nitrosourea compound of the formula: ##STR1## wherein R.sup.1 is an alicyclic group having 3 to 6 carbon atoms, phenyl, phenyl substituted with one to substituents selected from halogen, lower alkyl, lower alkoxy, hydroxy and nitro, or a heteromonocyclic group selected from oxiranyl, tetrahydrofuryl, 1,3-dioxolanyl, 1,4-dioxanyl, morpholino, tetrahydro-S,S-dioxo-thienyl, furyl, thienyl and pyridyl; R.sup.2 is aldopentofuranosyl, aldo-pentopyranosyl, aldo-hexopyranosyl or O-aldo-hexopyranosyl-(1.fwdarw.4)-aldo-hexopyranosyl; and A is a single bond or straight or branched alkylene having one to 3 carbon atoms, is prepared by nitrosation of a compound of the formula: ##STR2## wherein R.sup.1, R.sup.2 and A are the same as above. Said nitrosourea compound is useful as an anti-tumor or anti-leukemic agent however, effectiveness in human beings has not yet been demonstrated.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: December 23, 1980
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kenji Tsujihara, Masakatsu Ozeki, Yoshihisa Arai
  • Patent number: 4182757
    Abstract: A nitrosourea compound of the formula: ##STR1## wherein R.sup.1 is alkyl of one to six carbon atoms, hydroxyalkyl of one to six carbon atoms, alkenyl of three to five carbon atoms or alkynyl of three to five carbon atoms, R.sup.2 is aldopentofuranosyl, aldo-pentopyranosyl, aldo-hexopyranosyl, O-aldo-hexopyranosyl-(1.fwdarw.4)-aldo-hexopyranosyl or a group of the formula: --CH.sub.2 (CHOH).sub.n CH.sub.2 OH, and wherein n is zero or an integer of one to four. A method of preparation is disclosed whereby said nitrosourea compound is prepared by the nitrosation of a compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are the same as above. Said nitrosourea compound is useful as an anti-tumor or anti-leukemic agent.
    Type: Grant
    Filed: July 10, 1978
    Date of Patent: January 8, 1980
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kenji Tsujihara, Masakatsu Ozeki, Yoshihisa Arai