Patents by Inventor Masakazu Fujio
Masakazu Fujio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110130419Abstract: The invention provides a salt of (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one and a crystal thereof. (R)-3-[2-(2-Hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one monophosphate is a compound which is chemically stable, has high solubility, and shows less weight change due to humidity as compared to a free form and monohydrochloride dihydrate, and is superior as a bulk drug for pharmaceutical products.Type: ApplicationFiled: August 8, 2008Publication date: June 2, 2011Applicant: MITSUBISHI TANABE PHARMA CORPORATIONInventors: Masakazu Fujio, Toshihiko Tanaka, Hisao Takayanagi, Hiroyuki Satoh, Takanori Ito
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Publication number: 20110086053Abstract: This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.Type: ApplicationFiled: December 2, 2010Publication date: April 14, 2011Applicants: THE ROCKEFELLER UNIVERSITY, THE SCRIPPS RESEARCH INSTITUTEInventors: Moriya Tsuji, David D. Ho, Chi-Huey Wong, Douglass Wu, Masakazu Fujio, Xiangming Li
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Patent number: 7923013Abstract: This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.Type: GrantFiled: April 13, 2007Date of Patent: April 12, 2011Assignees: The Rockefeller University, The Scripps Research InstituteInventors: Moriya Tsuji, David D. Ho, Chi-Huey Wong, Douglass Wu, Masakazu Fujio, Xiangming Li
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Patent number: 7812178Abstract: The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.Type: GrantFiled: November 3, 2008Date of Patent: October 12, 2010Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Masakazu Fujio, Hiroyuki Satoh, Shinya Inoue, Toshifumi Matsumoto, Yasuhiro Egi
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Publication number: 20090233875Abstract: This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.Type: ApplicationFiled: February 18, 2009Publication date: September 17, 2009Applicants: The Rockefeller University, The Scripps Research InstituteInventors: Moriya TSUJI, David D. Ho, Chi-Huey Wong, Doug Wu, Masakazu Fujio
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Patent number: 7590651Abstract: The setting of a search condition is supported. Databases 130 and 140 store use frequency information about search conditions, co-occurrence frequency information between search conditions, relationship information unique to a particular field, use history information for each search condition, and simultaneous use history information. Based on a search condition that is already set, the database are referred to so as to calculate the recommendation level of other search conditions, and search conditions that have high recommendation levels and that are likely to be used simultaneously with the already-set search condition are arranged at conspicuous positions. The recommendation level is calculated based on the value of a co-occurrence frequency between search conditions, the history of simultaneous setting, or the estimated number of search results, for example.Type: GrantFiled: August 9, 2006Date of Patent: September 15, 2009Assignee: Hitachi, Ltd.Inventors: Masakazu Fujio, Yoshiki Niwa, Shigeo Sumino
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Patent number: 7534434Abstract: This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.Type: GrantFiled: December 27, 2005Date of Patent: May 19, 2009Assignees: The Rockefeller University, The Scripps Research InsitituteInventors: Moriya Tsuji, David D. Ho, Chi-Huey Wong, Doug Wu, Masakazu Fujio
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Publication number: 20090076276Abstract: The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.Type: ApplicationFiled: November 3, 2008Publication date: March 19, 2009Applicant: MITSUBISHI TANABE PHARMA CORPORATIONInventors: Masakazu FUJIO, Hiroyuki SATOH, Shinya INOUE, Toshifumi MATSUMOTO, Yasuhiro EGI
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Patent number: 7501412Abstract: The present invention relates to an isoquinoline compound represented by the following formula (I) or (II), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction.Type: GrantFiled: November 21, 2003Date of Patent: March 10, 2009Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Masakazu Fujio, Hiroyuki Satoh, Shinya Inoue, Toshifumi Matsumoto, Yasuhiro Egi, Taichi Takahashi
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Patent number: 7459465Abstract: The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.Type: GrantFiled: March 19, 2007Date of Patent: December 2, 2008Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Masakazu Fujio, Hiroyuki Satoh, Shinya Inoue, Toshifumi Matsumoto, Yasuhiro Egi
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Publication number: 20070276857Abstract: The setting of a search condition is supported. Databases 130 and 140 store use frequency information about search conditions, co-occurrence frequency information between search conditions, relationship information unique to a particular field, use history information for each search condition, and simultaneous use history information. Based on a search condition that is already set, the database are referred to so as to calculate the recommendation level of other search conditions, and search conditions that have high recommendation levels and that are likely to be used simultaneously with the already-set search condition are arranged at conspicuous positions. The recommendation level is calculated based on the value of a co-occurrence frequency between search conditions, the history of simultaneous setting, or the estimated number of search results, for example.Type: ApplicationFiled: August 9, 2006Publication date: November 29, 2007Inventors: Masakazu Fujio, Yoshiki Niwa, Shigeo Sumino
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Publication number: 20070238871Abstract: This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.Type: ApplicationFiled: April 13, 2007Publication date: October 11, 2007Applicants: THE ROCKEFELLER UNIVERSITY, THE SCRIPPS RESEARCH INSTITUTEInventors: Moriya Tsuji, David Ho, Chi-Huey Wong, Douglass Wu, Masakazu Fujio
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Publication number: 20070161620Abstract: The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.Type: ApplicationFiled: March 19, 2007Publication date: July 12, 2007Applicant: Mitsubishi Pharma CorporationInventors: Masakazu Fujio, Hiroyuki Satoh, Shinya Inoue, Toshifumi Matsumoto, Yasuhiro Egi
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Patent number: 7220759Abstract: The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.Type: GrantFiled: April 30, 2004Date of Patent: May 22, 2007Assignee: Mitsubishi Pharma CorporationInventors: Masakazu Fujio, Hiroyuki Satoh, Shinya Inoue, Toshifumi Matsumoto, Yasuhiro Egi
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Publication number: 20070100885Abstract: A system functioning between the clinical trial facility (trial site) and the party requesting clinical trial (sponsor) to make clinical trial more efficient. Information relating to the sponsor and information relating to the trial site, and trial basic information including the trial target disease name, the total length of trial (trial period), total number of cases and total budget registered by the sponsor, and trial contract conditions including the trial name, trial period, number of cases and budget are stored in a clinical trial database; and the process and information service unit distributes information on trial contract conditions registered in the contract information storage area to the trial site, registers applicant trial sites for trial relating to the distributed trial contract conditions, and distributes the status of applicant responses for trial contract conditions, to the trial sponsor who registered matching contract conditions.Type: ApplicationFiled: February 3, 2006Publication date: May 3, 2007Inventors: Shigeo Sumino, Masakazu Fujio, Yoshiki Niwa
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Publication number: 20060211856Abstract: This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.Type: ApplicationFiled: December 27, 2005Publication date: September 21, 2006Inventors: Moriya Tsuji, David Ho, Chi-Huey Wong, Doug Wu, Masakazu Fujio
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Patent number: 7047255Abstract: The present invention visualizes the contents of a plurality of documents without a lack of the listing property. Two document units are extracted from a document database and relevance degrees between individual elements of a group of the document units are calculated. The results are displayed on a two-dimensional coordinate plane depending on the relevance degree.Type: GrantFiled: February 27, 2003Date of Patent: May 16, 2006Assignee: Hitachi, Ltd.Inventors: Osamu Imaichi, Tetsuo Nishikawa, Toru Hisamitsu, Makoto Iwayama, Masakazu Fujio
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Publication number: 20060094743Abstract: The present invention relates to an isoquinoline compound represented by the following formula (I) or (II), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction.Type: ApplicationFiled: November 21, 2003Publication date: May 4, 2006Applicant: Mitsubishi Pharma CorporationInventors: Masakazu Fujio, Hiroyuki Satoh, Shinya Inoue, Toshifumi Matsumoto, Yasuhiro Egi, Taichi Takahashi
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Publication number: 20040248931Abstract: The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction.Type: ApplicationFiled: April 30, 2004Publication date: December 9, 2004Applicant: Mitsubishi Pharma CorporationInventors: Masakazu Fujio, Hiroyuki Satoh, Shinya Inoue, Toshifumi Matsumoto, Yasuhiro Egi
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Publication number: 20040176361Abstract: The fused heterocyclic compound of the present invention, which is represented by the formula (I): 1Type: ApplicationFiled: February 24, 2004Publication date: September 9, 2004Inventors: Masakazu Fujio, Hiroyuki Satoh, Atsushi Numata, Shinichi Takanashi, Yasuhiro Egi, Ryou Tatsumi