Patents by Inventor Masakazu Fukuda
Masakazu Fukuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240131233Abstract: The purpose of the present invention is to provide a pre-filled syringe formulation with staked needle, which contains an antibody at a high concentration and can be produced on an industrial scale in a simple manner without causing clogging. A pre-filled syringe formulation with staked needle, in which a protein solution is packed. The pre-filled syringe formulation is characterized in that a cap formed with a material having low water vapor permeability is provided at the needle.Type: ApplicationFiled: April 12, 2023Publication date: April 25, 2024Inventors: Rieko SHIOZAKI, Yuji YAMANAKA, Mika TAKAHASHI, Tadao YAMAZAKI, Masakazu FUKUDA, Shogo YAMASHITA
-
Publication number: 20230210991Abstract: In one non-limiting embodiment, the present disclosure is an antibody-containing formulation comprising an anti-IL-6 receptor antibody as an active ingredient, and contains histidine-aspartate buffer or histidine-glutamate buffer, Poloxamer 188, and arginine, and has a pH of 5.5 to 6.6. In one non-limiting embodiment, the present disclosure is a method of stabilizing an antibody-containing solution, a method of suppressing antibody association (e.g., dimerization), and a method of suppressing the generation of insoluble particles, wherein L-aspartic acid or L-glutamic acid, and optionally, Poloxamer 188 are added.Type: ApplicationFiled: May 28, 2021Publication date: July 6, 2023Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Daisuke Kameoka, Masaya Yasutake, Masakazu Fukuda, Atsushi Watanabe, Tomoyuki Igawa, Chifumi Imai, Akira Hayasaka
-
Publication number: 20230055601Abstract: A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.Type: ApplicationFiled: October 19, 2022Publication date: February 23, 2023Applicant: SYSMEX CORPORATIONInventors: Masakazu FUKUDA, Masamichi TANAKA, Yousuke TANAKA
-
Patent number: 11499908Abstract: A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.Type: GrantFiled: January 27, 2020Date of Patent: November 15, 2022Assignee: SYSMEX CORPORATIONInventors: Masakazu Fukuda, Masamichi Tanaka, Yousuke Tanaka
-
Patent number: 11360017Abstract: Provided is a biological sample imaging device and a biological sample imaging method that are capable of disposing a sufficient number of large-sized particles in a biological sample so as to be moderately dispersed within an imaging range. The biological sample imaging method includes: a first step of introducing a biological sample containing particles into a liquid flow channel; a second step of causing the biological sample introduced into the liquid flow channel to flow in a forward direction; a third step of causing the biological sample to flow in a reverse direction after the second step; and an imaging step of taking, in an imaging cell, images of the particles contained in the biological sample that remains in the liquid flow channel after the third step.Type: GrantFiled: July 20, 2018Date of Patent: June 14, 2022Assignee: SYSMEX CORPORATIONInventors: Masakazu Fukuda, Toshikuni Suganuma, Kazuhiro Kanou, Yanyan Liu
-
Patent number: 11059881Abstract: The inventors discovered that viscosity of a protein solution can be estimated by measuring the apparent particle size or apparent molecular weight by a small angle X-ray scattering (SAXS) method or X-ray solution scattering method, which enables measurement of small amounts of samples, and then correlating those measurement results with viscosity of the protein solution.Type: GrantFiled: January 14, 2020Date of Patent: July 13, 2021Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masakazu Fukuda, Akira Hayasaka, Tomoyuki Igawa, Atsuhiko Maeda, Machiko Fujino
-
Patent number: 11053530Abstract: Disclosed is a bacteria analyzing method comprising: irradiating with light a measurement sample prepared by mixing a specimen and a reagent; obtaining two types of optical information from each of at least some particles contained in the measurement sample; and generating a measurement result of the specimen with a flag representing morphological characteristics of bacteria contained in the specimen based on both of: (i) information indicative of a characteristic of a distribution pattern of particles plotted in a first region of a coordinate space including at least two axes, wherein the two types of optical information are scalable along the respective axes, and (ii) information representing a number of particles plotted in a second region being a part of the first region.Type: GrantFiled: June 3, 2014Date of Patent: July 6, 2021Assignee: SYSMEX CORPORATIONInventors: Masamichi Tanaka, Shota Tateyama, Masakazu Fukuda
-
Patent number: 10775362Abstract: The urine analyzer 10 includes a sample preparation unit 30 for mixing a urine sample with a hemolytic agent to prepare a measurement sample, a flow cell 41 for flowing a measurement sample, a light source 42 for irradiating light on the measurement sample flowing through the flow cell 41, a light receiving unit 50 for receiving scattered light given off from the measurement sample by irradiation of light and outputting a scattered light signal, and an analysis unit 12 for detecting fat particles in the measurement sample by using a parameter reflecting the intensity of the scattered light signal output by the light receiving unit 50, and a parameter reflecting the width of the scattered light signal.Type: GrantFiled: May 30, 2018Date of Patent: September 15, 2020Assignee: Sysmex CorporationInventors: Shota Tateyama, Masakazu Fukuda, Mitsumasa Sakamoto
-
Publication number: 20200283544Abstract: As antibody variants and isoforms having reduced FVIII mimetic activity than Emicizumab, the antibody variants having some specific amino acid residues in the variable region cleaved out and missing (Q-CDR-Clipped Variants) and the antibody isoforms having inter-heavy chain disulfide bonds less susceptible to reduction under mild reducing conditions (Protected Disulfide Isoforms) are provided.Type: ApplicationFiled: October 31, 2018Publication date: September 10, 2020Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Kensaku Hosoguchi, Maki Kuwayama, Chifumi Seida, Yosuke Watanabe, Nobuyuki Tanaka, Satoshi Saitoh, Masakazu Fukuda
-
Patent number: 10732168Abstract: Provided are a cell imaging device and a cell imaging method that can shorten the time period of taking images of cells in a liquid sample, compared with conventional techniques. This cell imaging device introduces a urine sample containing cells into an internal space of a sample cell, moves at least one of the sample cell and an objective lens in a second direction while at least one of the sample cell and the objective lens is moved in a first direction, the second direction being different from the first direction, and takes, at a plurality of imaging positions, images of cells contained in the urine sample by means of an imaging unit.Type: GrantFiled: June 20, 2017Date of Patent: August 4, 2020Assignee: SYSMEX CORPORATIONInventors: Masakazu Fukuda, Masamichi Tanaka, Yanyan Liu, Ryosuke Fujii, Takumi Inutsuka, Tomoyuki Tsukahara
-
Publication number: 20200158624Abstract: A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.Type: ApplicationFiled: January 27, 2020Publication date: May 21, 2020Applicant: SYSMEX CORPORATIONInventors: Masakazu FUKUDA, Masamichi TANAKA, Yousuke TANAKA
-
Publication number: 20200131250Abstract: The inventors discovered that viscosity of a protein solution can be estimated by measuring the apparent particle size or apparent molecular weight by a small angle X-ray scattering (SAXS) method or X-ray solution scattering method, which enables measurement of small amounts of samples, and then correlating those measurement results with viscosity of the protein solution.Type: ApplicationFiled: January 14, 2020Publication date: April 30, 2020Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Masakazu Fukuda, Akira Hayasaka, Tomoyuki Igawa, Atsuhiko Maeda, Machiko Fujino
-
Patent number: 10591709Abstract: A cell imaging apparatus captures images of cells contained in a liquid specimen comprising: an image capture unit including an objective lens, specimen cells each including an inner space which is capable of holding a liquid specimen and which is elongated in one direction, the specimen cells arranged such that the inner spaces are aligned in a row in a longitudinal direction of the inner spaces, a drive unit that moves at least one of: a) one or more specimen cells; and b) the objective lens; and a controller that controls the drive unit to move at least one of: a) one or more specimen cells; and b) the objective lens in the longitudinal direction and controls the image capture unit to capture images of cells contained in a liquid specimen held in the inner space of each of the specimen cells at multiple image capture positions.Type: GrantFiled: March 23, 2016Date of Patent: March 17, 2020Assignee: SYSMEX CORPORATIONInventors: Masakazu Fukuda, Yanyan Liu, Toshihiro Ootani
-
Patent number: 10585032Abstract: A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.Type: GrantFiled: September 26, 2017Date of Patent: March 10, 2020Assignee: SYSMEX CORPORATIONInventors: Masakazu Fukuda, Masamichi Tanaka, Yousuke Tanaka
-
Patent number: 10539553Abstract: Provided is a method for detecting a stem cell based on an undifferentiated sugar chain marker having a specific sugar chain structure, wherein the stem cell is detected by detecting podocalyxin contained in a culture supernatant or a lysate of cells by a “lectin-antibody sandwich method” using a combination of a lectin and an antibody and having high sensitivity, the method including steps of: contacting the culture supernatant or the lysate, a lectin capable of binding to a sugar chain represented by (Formula 1) or (Formula 2), and an antibody capable of binding to keratan sulfate to form a complex composed of the lectin, podocalyxin and the antibody; and detecting the complex. wherein R1 represents an OH group or any sugar chain and R2 represents an OH group or any sugar chain, protein, lipid, or another molecule. wherein R1 represents an OH group or any sugar chain and R2 represents an OH group or any sugar chain, protein, lipid, or another molecule.Type: GrantFiled: December 21, 2015Date of Patent: January 21, 2020Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, FUJIFILM WAKO PURE CHEMICAL CORPORATIONInventors: Hiroaki Tateno, Masaki Warashina, Masakazu Fukuda, Kazunari Hirayasu
-
Patent number: 10444439Abstract: An optical connector is disclosed. The optical connector includes an optical fiber, a ferrule that holds the optical fiber, the ferrule having a flat ferrule end surface facing a counterpart optical connector, and a spacer provided on the ferrule end surface so as to define a clearance between the ferrule end surface and the counterpart optical connector. A tip surface of the optical fiber is exposed at the ferrule end surface. Respective normal directions to the tip surface of the optical fiber and the ferrule end surface are inclined with respect to an optical-axis direction of the optical fiber in a section along an optical axis of the optical fiber. The spacer includes an opening configured to allow an optical path extending from the tip surface of the optical fiber to pass therethrough.Type: GrantFiled: October 18, 2016Date of Patent: October 15, 2019Assignee: SUMITOMO ELECTRIC INDUSTRIES, LTD.Inventors: Hajime Arao, Tomomi Sano, Osamu Shimakawa, Masakazu Fukuda, Takako Hosokawa
-
Publication number: 20180356330Abstract: Provided is a biological sample imaging device and a biological sample imaging method that are capable of disposing a sufficient number of large-sized particles in a biological sample so as to be moderately dispersed within an imaging range. The biological sample imaging method includes: a first step of introducing a biological sample containing particles into a liquid flow channel; a second step of causing the biological sample introduced into the liquid flow channel to flow in a forward direction; a third step of causing the biological sample to flow in a reverse direction after the second step; and an imaging step of taking, in an imaging cell, images of the particles contained in the biological sample that remains in the liquid flow channel after the third step.Type: ApplicationFiled: July 20, 2018Publication date: December 13, 2018Inventors: Masakazu FUKUDA, Toshikuni SUGANUMA, Kazuhiro KANOU, Yanyan LIU
-
Publication number: 20180348200Abstract: The urine analyzer 10 includes a sample preparation unit 30 for mixing a urine sample with a hemolytic agent to prepare a measurement sample, a flow cell 41 for flowing a measurement sample, a light source 42 for irradiating light on the measurement sample flowing through the flow cell 41, a light receiving unit 50 for receiving scattered light given off from the measurement sample by irradiation of light and outputting a scattered light signal, and an analysis unit 12 for detecting fat particles in the measurement sample by using a parameter reflecting the intensity of the scattered light signal output by the light receiving unit 50, and a parameter reflecting the width of the scattered light signal.Type: ApplicationFiled: May 30, 2018Publication date: December 6, 2018Inventors: Shota TATEYAMA, Masakazu FUKUDA, Mitsumasa SAKAMOTO
-
Publication number: 20180321446Abstract: An optical connector is disclosed. The optical connector includes an optical fiber, a ferrule that holds the optical fiber, the ferrule having a flat ferrule end surface facing a counterpart optical connector, and a spacer provided on the ferrule end surface so as to define a clearance between the ferrule end surface and the counterpart optical connector. A tip surface of the optical fiber is exposed at the ferrule end surface. Respective normal directions to the tip surface of the optical fiber and the ferrule end surface are inclined with respect to an optical-axis direction of the optical fiber in a section along an optical axis of the optical fiber. The spacer includes an opening configured to allow an optical path extending from the tip surface of the optical fiber to pass therethrough.Type: ApplicationFiled: October 18, 2016Publication date: November 8, 2018Applicant: SUMITOMO ELECTRIC INDUSTRIES, LTD.Inventors: Hajime ARAO, Tomomi SANO, Osamu SHIMAKAWA, Masakazu FUKUDA, Takako HOSOKAWA
-
Patent number: 9989469Abstract: Disclosed is a sample analyzer comprising: a sample measuring section including a detecting section for detecting a component contained in a sample and a flow path for feeding the sample to the detecting section; and a control section. The control section is programmed to automatically control the sample measuring section to flow a sample blank free of particles to the detecting section and detect a component contained in the sample blank to check a background of the detection after the sample measuring section performs washing of the flow path.Type: GrantFiled: March 29, 2013Date of Patent: June 5, 2018Assignee: SYSMEX CORPORATIONInventors: Masakazu Fukuda, Masamichi Tanaka, Rumi Takata