Masaki Harada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
Abstract: An object of the present invention is to provide an antibody specifically binding to CDH6 and having a high internalization activity, an antibody-drug conjugate comprising the antibody and a high antitumor activity, a pharmaceutical product having the antibody-drug conjugate and having a therapeutic effect on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like. According to the present invention, it is possible to provide an anti-CDH6 antibody prepared having internalization activity, an anti-CDH6 antibody-drug conjugate prepared by connecting the anti-CDH6 antibody and a novel PBD derivative and exhibiting high anti-tumor activity, a pharmaceutical product and a therapeutic method for treating tumors using these.
November 13, 2019
January 20, 2022
DAIICHI SANKYO COMPANY, LIMITED
Atsuko SAITO, Naoya HARADA, Kozo YONEDA, Ichiro HAYAKAWA, Masaki MEGURO, Fuminao DOI
Abstract: A substrate processing apparatus comprising: a substrate process chamber having a plasma generation space where a processing gas is plasma-excited and a substrate processing space communicating with the plasma generation space; a substrate mounting table installed inside the substrate processing space and for mounting a substrate; an inductive coupling structure provided with a coil installed to be wound around an outer periphery of the plasma generation space; a substrate support table elevating part for raising and lowering the substrate mounting table; a gas supply part for supplying the processing gas to the plasma generation space; and a controller for controlling the substrate support table elevating part, based on a power value of a high-frequency power supplied to the coil, so that the substrate mounted on the substrate mounting table is positioned at a target height according to the power value and spaced apart from a lower end of the coil.
Abstract: A cuff unit, a method for manufacturing the cuff unit, and a blood pressure measuring device that allow suppressing a positional deviation in each of a pressing cuff and a sensing cuff with respect to a curler are provided. A cuff unit includes a pressing cuff joined to a curler and including a plurality of air bags that are layered and each inflated by a fluid, and a sensing cuff that includes one air bag inflated by a fluid and a joining margin formed on the air bag and joined to the air bag 81 adjacent to the air bag.
Abstract: Provided is a blood pressure measurement device including a curler including a cover portion that fixes a device body to a hand back side of the wrist, a pressing cuff including a first bag-like structure and a first flow path body which is integrally formed with the first bag-like structure by joining two sheet members forming the first bag-like structure facing the curler and is fluidly connecting a pump and the first bag-like structure, a sensing cuff including a second bag-like structure and a second flow path body which is integrally formed with the second bag-like structure by joining two sheet members forming the second bag-like structure and is including one end disposed on the wrist side of the cover portion, and a tensile cuff including a third bag-like structure.
Abstract: A blood pressure measurement device includes a device main body, a curler, and a sensing cuff. The curler curves following a circumferential direction of a wrist from a hand back side of the wrist to a region where at least an artery is present on a hand palm side of the wrist. The curler includes a cover portion that fixes the device main body to the hand back side of the wrist. The curler has a curvature of an end portion on a short-hand side from the cover portion set smaller than a curvature of an end portion on a long-hand side from the device main body. The end portion on the short-hand side is separated from the end portion on the long-hand side. The sensing cuff is provided on the long-hand side of the curler and an inner circumferential surface on the hand palm side of the wrist.
Abstract: Provided is a cuff cover for a blood pressure measurement device including a bag body having a stretchable bag-like shape with a length that allows a cuff structure and a curler curving and following along a shape of the wrist to be disposed inside the bag body, a first hole portion extending in a longitudinal direction of the bag body and provided at a portion of the bag body facing the outer circumferential surface of the curler, the first hole portion being configured to allow the curler provided with the cuff structure to be inserted by elongating the bag body, and a second hole portion formed in a shape allowing the power feeding terminal to be exposed, the second hole portion being provided at a portion of the bag body facing the power feeding terminal provided on the outer circumferential surface of the curler.
Abstract: A motor includes a connector detachably connected with an external cable and a resin sealing member which covers the connector. The connector includes a frame part into which a cable side connector is to be inserted and a step part on an outer peripheral face of the frame part. A shape of the step part when viewed in the inserting direction is a ring shape. The resin sealing member covers the connector from the front side and exposes an end face of the step part of the frame part and a portion of the frame part on the rear side to the step part end face to the outside, and an outer peripheral face of the resin sealing member is provided with an outer peripheral face portion which surrounds the frame part and is continuously connected with the step part end face without a step.
Abstract: A motor includes a rotor, a stator having coils, a connector for supplying electrical power to the coils, and a resin sealing member. The resin sealing member comprises an opposite-to-output side sealing part and a connector sealing part covering the connector. The connector comprises a frame part into which the cable side connector is to be inserted, and the opposite-to-output side sealing part comprises a first protruded part and a second protruded part. A tip end face of the first protruded part and a tip end face of the second protruded part are located on one imaginary face intersecting the rotation center line, a tip end on the opposite-to-output side of the frame part is located on the output side with respect to the imaginary face, and the second protruded part is provided at a position closer to the frame part between the first protruded part and the frame part.
Abstract: A motor includes a rotor having an output shaft and a rotor main body, a bearing member for supporting the output shaft movable in an axial line direction and rotatable around the axial line, and a bearing holding member holding the bearing member. The bearing member has a tube part supporting the output shaft and a slidably contacting part capable of slidably contacting with the rotor main body. The bearing holding member has an opposed face facing the rotor main body and a recessed part provided in the opposed face. The tube part of the bearing member is inserted into the recessed part and is separated from a bottom face of the recessed part. A space between the bottom face of the recessed part and the tube part is structured as a lubricant storage part and a communication path is provided between the bearing holding member and the bearing member.
Abstract: A sensor relating to the present invention includes: a first electrode; a second electrode; a first attracting portion positioned between the first electrode and the second electrode and configured to receive conductive abrasion powder contained in a detection region and attracted onto the first attracting portion; a sensing unit for sensing a change in electrical resistance between the first electrode and the second electrode caused by the conductive abrasion powder; and at least one second attracting portion positioned within the detection region and configured to attract the conductive abrasion powder contained in the detection region.
Abstract: The present application discloses an engine room structure of a vehicle including: a partitioning wall configured to partition a storage space in which an engine is stored from a piping space to form an intake passage for supplying air to a combustion chamber of the engine; and an intake pipe which partially forms the intake passage in the piping space, wherein the intake pipe extends along the partitioning wall, the intake pipe being integrally formed with the partitioning wall.
Abstract: A sensor relating to one embodiment of the present invention includes a first electrode, a second electrode, an attracting portion arranged between the first electrode and the second electrode, where the attracting portion attracts conductive particles smaller than a gap between the first electrode and the second electrode to cause a change in electrical resistance between the first electrode and the second electrode, and a short circuit preventing portion for preventing a large-diameter conductive piece from causing a short circuit between the first electrode and the second electrode, where the large-diameter conductive piece has a larger dimension than the gap between the first electrode and the second electrode.
March 25, 2020
October 29, 2020
Kazuhiko SAKURAI, Masaki HARADA, Koki AKAI, Shuichi KAMAGATA
Abstract: A method for manufacturing a blood pressure measurement cuff includes preparing an outer cloth, preparing an inner cloth, and forming a bag-shaped portion. The bag-shaped portion has an opening on a peripheral edge of the bag-shaped portion. A curler is inserted into the bag-shaped portion through the opening, the curler being flexible and configured to curve and conform to the measurement site. An air bladder is formed by welding the opening of the bag-shaped portion such that the air bladder surrounds an inner side and an outer side of the curler thereby containing the curler. The outer cloth is attached to an outer surface on a first side of the air bladder configured to be opposite to the measurement site, and the inner cloth is attached to an outer surface on a second side of the air bladder configured to be towards the measurement site.
Abstract: One object is to increase the amount of abrasion powder accumulated in a sensing region to improve the sensitivity in sensing the abrasion powder. Provided is a sensor for sensing reduction of electric resistance between electrodes, a magnetic field being applied between the electrodes to accumulate magnetic powder floating in a lubricant between the electrodes, wherein at least one sensing region in which the magnetic powder is to be accumulated is provided in at least a part of a region between the electrodes, and the magnetic powder is inhibited from being accumulated in a non-sensing region constituted by a space around the electrodes other than the at least one sensing region.
Abstract: Provided is an aluminum alloy clad material including an aluminum alloy core material, an intermediate layer material that is clad on one surface of the core material, and a first brazing filler metal that is clad on a surface of the intermediate layer material, the surface not being on the core material side, wherein the core material, the intermediate layer material, and the first brazing filler metal each include an aluminum alloy having a predetermined composition, the existence density of Al—Mn based intermetallic compounds having a circle-equivalent diameter between 0.1 and 1.0 ?m inclusive in the intermediate layer material before brazing heating is at least 1.0×105 pieces/mm2, and the existence density of Al—Mn based intermetallic compounds having a circle-equivalent diameter between 0.1 and 1.0 ?m inclusive in the intermediate layer material after brazing heating is at least 1.0×104 pieces/mm2. Further provided is a method for producing the aluminum alloy clad material.
Abstract: A motor may include a rotor provided with a rotating shaft that protrudes to a first side in an axial direction; a stator disposed on an outer peripheral side of the rotor; a resin sealing member that covers the stator; and a cover member that is disposed on the first side of the resin sealing member and supports the rotating shaft. The cover member may include a plurality of gate marks disposed at different angular positions and a plurality of ribs that protrude to a second side in the axial direction.
Abstract: A rotor may include a rotation shaft, a magnet on an outer peripheral side, a holding member holding the rotation shaft and the magnet, and a plurality of recessed parts provided in an end face of the magnet in an axial line direction of the rotation shaft so as to be separated from each other in a circumferential direction. A surface of each of the recessed parts is formed in a spherical shape, the holding member has a flange portion which covers the end face of the magnet from an end on an inner peripheral side of the end face of the magnet to an outer peripheral side with respect to the plurality of the recessed parts, and the flange portion is adhered to the surfaces of the recessed parts.
Abstract: An intercooler includes a heating portion in which flow path tubes and fins are stacked with each other. A second cooling medium flow path of the flow path tubes is located upstream of a first cooling medium flow path of the flow path tubes with respect to a flow direction of supercharged intake air. The second cooling medium flow path includes a second U-turn portion in which the second cooling medium makes a U-turn. In the second cooling medium flow path, a downstream flow path located downstream of the second U-turn portion is located upstream, in the flow direction of the supercharged intake air, of an upstream flow path located upstream of the second U-turn portion. The fins include a heat exchange limiting portion at least in a part adjacent to a most upstream part, in the flow direction of the supercharged intake air, of the downstream flow path.
Abstract: Provided is an aluminum alloy clad material including an aluminum alloy core material and a first brazing filler metal that is clad on one surface or both surfaces of the core material, wherein the core material and the first brazing filler metal each include an aluminum alloy having a predetermined composition, the existence density of Al—Mn based intermetallic compounds having a circle-equivalent diameter of at least 0.1 ?m in the first brazing filler metal before brazing heating is at least 1.0×105 pieces/mm2, and the existence density of Al—Mn based intermetallic compounds having a circle-equivalent diameter of at least 2 ?m in the first brazing filler metal after brazing heating is at least 300 pieces/mm2. Further provided are a method for producing the aluminum alloy clad material and a heat exchanger employing the aluminum alloy clad material.