Abstract: The present disclosure provides, for example, a compound represented by the general formula below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X1, X2, X3 and X4 are each independently —CR2? or N?, R2 is, for example, a halogen atom, R1 is, for example, —S(?O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.

Abstract: There is provided a calculation method of calculating a starting point (Xs, Ys) of signal rise from a fluorescence signal measured using a biological sample, wherein the fluorescence signal is time-series data including a dataset (measurement time, fluorescence intensity) of the fluorescence intensity for the measurement time and wherein the calculation method includes a process of calculating a temporary starting point (Xs?, Ys?) and a process of calculating the starting point (Xs, Ys) of the signal rise on the basis of the temporary starting point (Xs?, Ys?).

Abstract: Brightness profile data are extracted based on side view image data of an optical fiber, machine learning is performed by using teacher data indicating a correspondence relationship between brightness profile in a radial direction of the optical fiber and a type of the optical fiber, the teacher data being created based on the brightness profile data, a classification model is created to be able to determine the type of the optical fiber for an arbitrary optical fiber based on the brightness profile data indicating brightness profile in the radial direction of the arbitrary optical fiber, and the type of the optical fiber is determined for each of a pair of optical fibers by using the classification model based on the brightness profile data that is extracted based on side view image data of the pair of optical fibers as a target. The pair of optical fibers are fusion-spliced based on a fusion condition that is set in accordance with a combination of respective determined types of the optical fibers.

Abstract: A ceramic element includes: a ceramic body; a first coating layer disposed on a first part of a front surface of the ceramic body; and a second coating layer disposed on a second part of a back surface of the ceramic body. The first coating layer continuously extends from the front surface to a first region of a side surface of the ceramic body, the side surface being a machined surface, and the first region being a front side region of the side surface. The second coating layer continuously extends from the back surface to a second region of the side surface of the ceramic body, the second region being a back side region of the side surface. In the machined surface, one of the first and second coating layers is disposed at least partially on the other of the first and second coating layers.

Abstract: A ceramic element includes: a ceramic body; a first coating layer disposed on a first part of a front surface of the ceramic body; and a second coating layer disposed on a second part of a back surface of the ceramic body. The first coating layer continuously extends from the front surface to a first region of a side surface of the ceramic body, the side surface being a machined surface, and the first region being a front side region of the side surface. The second coating layer continuously extends from the back surface to a second region of the side surface of the ceramic body, the second region being a back side region of the side surface. In the machined surface, one of the first and second coating layers is disposed at least partially on the other of the first and second coating layers.

Abstract: An optical power supply type sensing system includes: an optical directivity coupler (6) mounted in a sensor unit (1); a photo-electric converter (4) connected to a first optical fiber (5) among the first to the third optical fiber (5, 7, 8) connected to the optical directivity coupler (6); an optical output device (3) connected to the second optical fiber (7); and a measurement device (10) connected to the third optical fiber (8) drawn out of the sensor unit (1).

Abstract: A vehicle seat may include a seat back that has a back frame, a cushion pad attached to the back frame, and a massaging unit having a plurality of massaging elements. The cushion pad has a plurality of through bores that pass therethrough in the direction of thickness thereof. The massaging elements are constructed so as to be elastically deformed or compressed along moving axes and to be pneumatically expanded and contracted along the moving axes. The massaging elements are disposed in the through bores in a manner that the moving axes of the massaging elements extend along longitudinal axes of the through bores. The massaging elements have deformability or compressibility identical with or greater than the deformability or compressibility of the cushion pad when the massaging elements are not operated.

Abstract: An optical power supply type sensing system includes: an optical directivity coupler (6) mounted in a sensor unit (1); a photo-electric converter (4) connected to a first optical fiber (5) among the first to the third optical fiber (5, 7, 8) connected to the optical directivity coupler (6); an optical output device (3) connected to the second optical fiber (7); and a measurement device (10) connected to the third optical fiber (8) drawn out of the sensor unit (1).

Abstract: A vehicle seat may include a seat back that has a back frame, a cushion pad attached to the back frame, and a massaging unit having a plurality of massaging elements. The cushion pad has a plurality of through bores that pass therethrough in the direction of thickness thereof. The massaging elements are constructed so as to be elastically deformed or compressed along moving axes and to be pneumatically expanded and contracted along the moving axes. The massaging elements are disposed in the through bores in a manner that the moving axes of the massaging elements extend along longitudinal axes of the through bores. The massaging elements have deformability or compressibility identical with or greater than the deformability or compressibility of the cushion pad when the massaging elements are not operated.