Patents by Inventor Masaki Ieda

Masaki Ieda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reagent for differentiating somatic cells into alveolar epithelial cells, and use of said reagent
    Patent number: 11718831
    Abstract: A reagent for differentiating somatic cells into alveolar epithelial cells includes an NK2 homeobox family gene expression vector, and a Fox family gene expression vector, a method for manufacturing alveolar epithelial cells, the method including forcing a somatic cell to express an NK2 homeobox family gene and a Fox family gene and culturing the somatic cell after forced expression, an alveolar epithelial cell manufactured by the manufacturing method, and a cell medicine including the alveolar epithelial cell.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: August 8, 2023
    Assignee: KEIO UNIVERSITY
    Inventors: Makoto Ishii, Tomoko Betsuyaku, Minoru Ko, Masaki Ieda, Masaya Yotsukura, Hisao Asamura, Ahmed Hegab, Yuhki Nakatake, Mayumi Oda
  • REAGENT FOR DIFFERENTIATING SOMATIC CELLS INTO ALVEOLAR EPITHELIAL CELLS, AND USE OF SAID REAGENT
    Publication number: 20200318074
    Abstract: A reagent for differentiating somatic cells into alveolar epithelial cells includes an NK2 homeobox family gene expression vector, and a Fox family gene expression vector.
    Type: Application
    Filed: April 19, 2018
    Publication date: October 8, 2020
    Inventors: Makoto ISHII, Tomoko BETSUYAKU, Minoru KO, Masaki IEDA, Masaya YOTSUKURA, Hisao ASAMURA, Ahmed HEGAB, Yuhki NAKATAKE, Mayumi ODA
  • METHOD FOR PRODUCING CARDIAC PRECURSOR CELL AND MYOCARDIAL CELL FROM PLURIPOTENT STEM CELL
    Publication number: 20190078053
    Abstract: Provided is a method of inducing cardiac progenitor cells or cardiomyocytes from pluripotent stem cells. The present invention provides a method for producing cardiac progenitor cells from pluripotent stem cells, comprising expressing Tbx6 in the pluripotent stem cells. Moreover, the present invention provides a method for producing cardiomyocytes from pluripotent stem cells, comprising: a step of inducing cardiac progenitor cells from pluripotent stem cells, comprising expressing a Tbx6 gene in the pluripotent stem cells; and a step of inducing cardiomyocytes from the cardiac progenitor cells induced in the above step, comprising suppressing the expression of the Tbx6 gene.
    Type: Application
    Filed: March 7, 2017
    Publication date: March 14, 2019
    Applicants: Keio University, National Institute of Advanced Industrial Science and Technology
    Inventors: Masaki IEDA, Taketaro SADAHIRO, Mari ISOMI, Naoki GOSHIMA
  • METHOD FOR DIRECTLY PRODUCING CARDIAC PRECURSOR CELL OR MYOCARDIAL CELL FROM FIBROBLAST
    Publication number: 20190071641
    Abstract: Provided is a method of inducing cardiac progenitor cells or cardiomyocytes from fibroblasts. The present invention provides a method for producing cardiac progenitor cells, comprising introducing one cardiac reprogramming factor into fibroblasts, or a method for producing cardiomyocytes, comprising introducing three cardiac reprogramming factors into fibroblasts.
    Type: Application
    Filed: March 7, 2017
    Publication date: March 7, 2019
    Applicants: Keio University, National Institute of Advanced Industrial Science and Technology
    Inventors: Masaki IEDA, Taketaro SADAHIRO, Mari ISOMI, Naoki GOSHIMA
  • Methods for generating cardiomyocytes
    Patent number: 9517251
    Abstract: The present disclosure provides method of generating cardiomyocytes from post-natal fibroblasts. The present disclosure further provides cells and compositions for use in generating cardiomyocytes.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: December 13, 2016
    Assignee: The J. David Gladstone Institutes
    Inventors: Deepak Srivastava, Masaki Ieda
  • Methods for generating cardiomyocytes
    Patent number: 9517250
    Abstract: The present disclosure provides method of generating cardiomyocytes from post-natal fibroblasts. The present disclosure further provides cells and compositions for use in generating cardiomyocytes.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: December 13, 2016
    Assignee: The J. David Gladstone Institutes
    Inventors: Deepak Srivastava, Masaki Ieda
  • Methods for Generating Cardiomyocytes
    Publication number: 20140235526
    Abstract: The present disclosure provides method of generating cardiomyocytes from post-natal fibroblasts. The present disclosure further provides cells and compositions for use in generating cardiomyocytes.
    Type: Application
    Filed: March 19, 2014
    Publication date: August 21, 2014
    Applicant: The J. David Gladstone Institutes
    Inventors: Deepak Srivastava, Masaki Ieda
  • Methods for Generating Cardiomyocytes
    Publication number: 20130216503
    Abstract: The present disclosure provides method of generating cardiomyocytes from post-natal fibroblasts. The present disclosure further provides cells and compositions for use in generating cardiomyocytes.
    Type: Application
    Filed: April 26, 2011
    Publication date: August 22, 2013
    Applicant: THE J. DAVID GLADSTONE INSTITUTES
    Inventors: Deepak Srivastava, Masaki Ieda