Patents by Inventor Masaki KUROGOCHI

Masaki KUROGOCHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing glycan-hydrolyzed antibody, and homogeneous glycosylated antibody
    Patent number: 9550834
    Abstract: The present invention is aimed to provide a method for preparing an acceptor that is N-glycan hydrolyzed antibody or a Fc fragment thereof used for producing antibody having a homogeneous N-glycan structure; a method for determining a combination of endoglycosidases for use in said preparation; and a method for measuring N-glycans linked to an antibody. The present invention is directed to a method for producing a N-glycan hydrolyzed antibody or Fc fragment thereof, comprising reacting the antibody or the Fc fragment thereof with several endoglycosidases; and a method for determining quantitative information of an objective N-glycan with a desired structure linked to an antibody or a Fc thereof, comprising a protease treatment step and a glycopeptide measurement step, etc.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: January 24, 2017
    Assignees: THE NOGUCHI INSTITUTE, IMMUNO-BIOLOGICAL LABORATORIES CO., LTD.
    Inventors: Takashi Shirai, Masako Mori, Masaki Kurogochi, Masahiro Tomita
  • METHOD FOR PREPARING GLYCAN-HYDROLYZED ANTIBODY, AND HOMOGENEOUS GLYCOSYLATED ANTIBODY
    Publication number: 20160032010
    Abstract: The present invention is aimed to provide a method for preparing an acceptor that is N-glycan hydrolyzed antibody or a Fc fragment thereof used for producing antibody having a homogeneous N-glycan structure; a method for determining a combination of endoglycosidases for use in said preparation; and a method for measuring N-glycans linked to an antibody. The present invention is directed to a method for producing a N-glycan hydrolyzed antibody or Fc fragment thereof, comprising reacting the antibody or the Fc fragment thereof with several endoglycosidases; and a method for determining quantitative information of an objective N-glycan with a desired structure linked to an antibody or a Fc thereof, comprising a protease treatment step and a glycopeptide measurement step, etc.
    Type: Application
    Filed: April 17, 2015
    Publication date: February 4, 2016
    Applicants: THE NOGUCHI INSTITUTE, IMMUNO-BIOLOGICAL LABORATORIES CO., LTD.
    Inventors: Takashi SHIRAI, Masako MORI, Masaki KUROGOCHI, Masahiro TOMITA