Abstract: The present invention provides a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and/or cancer including colorectal cancer. The present invention relates to a compound of formula [I-a], [I-b] or [I-c] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification.

Abstract: A gas turbine combustor according to at least one embodiment of the present disclosure includes a first burner with a plurality of first nozzles disposed along an inner circumference of a cylindrical combustion tube, and a second nozzle surrounded by the plurality of first nozzles. The second nozzle has a fuel injection hole capable of injecting fuel. A distance between a centroid of the fuel injection hole and an outer peripheral edge of the fuel injection hole as viewed from an axial direction of the combustion tube differs depending on a position of the outer peripheral edge in a circumferential direction of the combustion tube.

Abstract: Provided are a combustor nozzle, a gas turbine combustor, a gas turbine, a cover ring, and a combustor nozzle manufacturing method. The combustor nozzle includes: a nozzle body provided with a fuel flow passage; a cover ring that is disposed on an outer side of the nozzle body so as to form air flow passages that allow air to jet out toward a front side; and fuel injection nozzles that are provided in a leading end part of the nozzle body at predetermined intervals in a circumferential direction and extend through the cover ring so as to be able to inject fuel from the fuel flow passage toward the front side.

Abstract: A cylinder for a combustor includes a cylindrical member, a first cooling passage defined in the cylindrical member and a second cooling passage defined in the cylindrical member, and a supply port extender. The first cooling passage includes a supply port that opens to an outer peripheral surface of the cylindrical member. The second cooling passage includes a discharge port that opens to the outer peripheral surface of the cylindrical member downstream of the supply port. The supply port extender includes a first wall that is disposed between the supply port and the discharge port and extends away from the outer peripheral surface of the cylindrical member and a second wall that is disposed upstream of the supply port and extends away from the outer peripheral surface of the cylindrical member.

Abstract: Provided are a combustor nozzle, a gas turbine combustor, a gas turbine, a cover ring, and a combustor nozzle manufacturing method. The combustor nozzle includes: a nozzle body provided with a fuel flow passage; a cover ring that is disposed on an outer side of the nozzle body so as to form air flow passages that allow air to jet out toward a front side; and fuel injection nozzles that are provided in a leading end part of the nozzle body at predetermined intervals in a circumferential direction and extend through the cover ring so as to be able to inject fuel from the fuel flow passage toward the front side.

Abstract: A cylinder for a combustor provided with a cylindrical member, a first cooling passage and a second cooling passage formed in the cylindrical member, and a supply port extended portion. The first cooling passage includes a supply port that opens to an outer peripheral surface of the cylindrical member. The second cooling passage includes a discharge port that opens to the outer peripheral surface of the cylindrical member downstream of the supply port. The supply port extended portion includes a first wall portion disposed between the supply port and the discharge port extending away from the outer peripheral surface of the cylindrical member and a second wall portion disposed upstream of the supply port extending away from the outer peripheral surface of the cylindrical member.

Abstract: A pilot nozzle, a gas turbine combustor and a gas turbine are provided with a nozzle main body having a fuel passage, a cover ring arranged at an outside of a front end-outer peripheral portion of the nozzle main body at a predetermined interval to form an inner air passage and capable of injecting air toward a front side of the nozzle main body, a plurality of nozzle tips that includes a fuel injection nozzle attached to a front end portion of the cover ring at a predetermined interval in a circumferential direction to communicate with the fuel passage and is able to inject fuel toward an outside of injection air from the inner air passage, and a swirling force application unit that applies a swirling force to air injected through the inner air passage.

Abstract: A pilot nozzle, a gas turbine combustor and a gas turbine are provided with a nozzle main body having a fuel passage, a cover ring arranged at an outside of a front end-outer peripheral portion of the nozzle main body at a predetermined interval to form an inner air passage and capable of injecting air toward a front side of the nozzle main body, a plurality of nozzle tips that includes a fuel injection nozzle attached to a front end portion of the cover ring at a predetermined interval in a circumferential direction to communicate with the fuel passage and is able to inject fuel toward an outside of injection air from the inner air passage, and a swirling force application unit that applies a swirling force to air injected through the inner air passage.

Abstract: Biphenyl derivatives represented by the following formula (1): wherein R1 represents a C5-7 alkyl group, R2 represents a substituted or unsubstituted aromatic hydrocarbon, or cycloalkyl group, R3 represents a tetrazolyl group, —NHCOCF3, —NHSO2CF3 or —SO2NHCONHR4 in which R4 represents a substituted or unsubstituted aromatic hydrocarbon group, and Z represents a single bond, a C1-4 alkylene group or —SO2NH—, and salts thereof; and ACAT inhibitors and medicines containing them as active ingredients. The compounds according to the present invention possess excellent ACAT inhibitory activities, and are useful as preventives and/or therapeutics for diseases cased by the enhancement of ACAT activity, for example, hypercholesterolemia, atherosclerosis and the like.

Abstract: Biphenyl derivatives represented by the following formula (1): 1

Abstract: A method for inhibiting dopamine re-uptake and treating Parkinson's disease is disclosed comprising administering a compound represented by formula (1) or a physiologically acceptable salt thereof as the active ingredient: ##STR1## wherein R.sup.1 and R.sup.2 represent each hydrogen or halogen, R.sup.3 represents hydrogen, alkyl or acyl, R.sup.4 represents hydrogen, alkyl, acyl, alkylsulfonyl or optionally esterified carboxyl, Ar represents optionally substituted phenyl or nitrogenous monocyclic heteroaromatic group, m represents a number of 1 to 5, and n represents a number of 0 to 5.