Patents by Inventor Masaki Ohtawa

Masaki Ohtawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compound having inhibitory activity against cholesterol acyltransferase isozyme 2 (ACAT2)
    Patent number: 9896456
    Abstract: This invention provides a novel non-natural pharmaceutical compound having a different mechanism than statin drugs and having a selective inhibitory activity against ACAT2.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: February 20, 2018
    Assignee: School Juridical Person Kitasato Institute
    Inventors: Hiroshi Tomoda, Masaki Ohtawa, Satoshi Omura, Tohru Nagamitsu
  • NOVEL PHARMACEUTICAL COMPOUND HAVING INHIBITORY ACTIVITY AGAINST CHOLESTEROL ACYLTRANSFERASE ISOZYME 2 (ACAT2)
    Publication number: 20170204114
    Abstract: This invention provides a novel non-natural pharmaceutical compound having a different mechanism than statin drugs and having a selective inhibitory activity against ACAT2.
    Type: Application
    Filed: June 18, 2015
    Publication date: July 20, 2017
    Applicant: School Juridical Person Kitasato Institute
    Inventors: Hiroshi Tomoda, Masaki Ohtawa, Satoshi Omura, Tohru Nagamitsu
  • Pyripyropene derivative having ACAT2 inhibiting activity and stable to metabolizing enzymes
    Patent number: 9187492
    Abstract: A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula —O—CH(R7)—R8 where R7 is a lower alkoxy group and R8 is an aryl group, and R2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a —CH2-acyloxy group and R3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R4 and R3 is a group other than acetoxy, or R2 and R3 taken together form a group of the formula —O—CH(R5)—O— where R5 is an aryl group.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: November 17, 2015
    Assignee: School Juridical Person Kitasato Institute
    Inventors: Hiroshi Tomoda, Tohru Nagamitsu, Daisuke Matsuda, Taichi Ohshiro, Masaki Ohtawa, Satoshi Omura
  • Pyripyropene Derivative Having ACAT2 Inhibiting Activity and Stable to Metabolizing Enzymes
    Publication number: 20130085163
    Abstract: A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula —13—O—CH(R7)—R8 where R7 is a lower alkoxy group and R8 is an aryl group, and R2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a —CH2-acyloxy group and R3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R4 and R3 is a group other than acetoxy, or R2 and R3 taken together form a group of the formula —O—CH(R5)—O— where R5 is an aryl group.
    Type: Application
    Filed: March 25, 2011
    Publication date: April 4, 2013
    Applicant: SCHOOL JURIDICAL PERSON KITASATO INSTITUTE
    Inventors: Hiroshi Tomoda, Tohru Nagamitsu, Daisuke Matsuda, Taichi Ohshiro, Masaki Ohtawa, Satoshi Omura