Patents by Inventor Masaki Shiba
Masaki Shiba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9889443Abstract: A sample analyzer including a reagent reservoir configured to store a plurality of reagent containers; a first reagent dispenser configured to aspirate reagent of a first type from the reagent reservoir and dispense the aspirated reagent into a reaction container disposed at a first dispensing position; a second reagent dispenser configured to aspirate reagent of a second type from the reagent reservoir and dispense the aspirated reagent into a reaction container disposed at a second dispensing position; and a support member configured to support the first and the second reagent dispensers; wherein the first and the second reagent dispensers are supported by the support member so as to be movable independently of each other between each dispensing position and the reagent reservoir is disclosed. A sample analyzing method executed by a sample analyzer is also disclosed.Type: GrantFiled: March 26, 2015Date of Patent: February 13, 2018Assignee: SYSMEX CORPORATIONInventors: Toshikatsu Fukuju, Masanori Imazu, Masaki Shiba
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Patent number: 9645160Abstract: The automatic analysis device measures time sequential data on a scattered light amount as reaction process data, and quantitatively determines the concentration of an analyte from a change in light amount. The automatic analysis device has a function of selecting reaction process data to be used for quantitative determination from the reaction process data obtained by measurement using a plurality of light receivers at different angles. As a result of using this function, data is selected from the reaction process data obtained by measurement using the plurality of light receivers at different angles in accordance with the concentration of the analyte and whether the priority is given to high sensitivity in the case where sensitivity is prioritized or a dynamic range, and the result of the quantitative determination is displayed.Type: GrantFiled: May 9, 2012Date of Patent: May 9, 2017Assignee: Hitachi High-Technologies CorporationInventors: Sakuichiro Adachi, Tomonori Mimura, Hajime Yamazaki, Masaki Shiba
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Publication number: 20170010292Abstract: The automatic analyzer includes: a first reagent container storage section storing a plurality of reagent containers; a regent dispensing mechanism for dispensing a reagent from a reagent container stored in the first reagent container storage section; a second reagent container storage section storing a plurality of reagent containers; a reagent container transfer mechanism for transferring a reagent container selected from among reagent containers stored in the second reagent container storage section to the first reagent container storage section; and a controller configured to control the reagent container transfer mechanism to transfer a reagent container from the second reagent container storage section to the first reagent container storage section on the basis of a predetermined priority condition. The predetermined priority condition is one of a reagent provided with an effective calibration curve result, a number of remaining tests, and an expiration date of a reagent.Type: ApplicationFiled: September 26, 2016Publication date: January 12, 2017Inventors: Masaki SHIBA, Masaaki HANAWA, Masaharu NISHIDA, Hitoshi OTAKE
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Patent number: 9513302Abstract: The automatic analyzer includes: a first reagent container storage section storing a plurality of reagent containers; a regent dispensing mechanism for dispensing a reagent from a reagent container stored in the first reagent container storage section; a second reagent container storage section storing a plurality of reagent containers; a reagent container transfer mechanism for transferring a reagent container selected from among reagent containers stored in the second reagent container storage section to the first reagent container storage section; and a controller configured to control the reagent container transfer mechanism to transfer a reagent container from the second reagent container storage section to the first reagent container storage section on the basis of a predetermined priority condition. The predetermined priority condition is one of a reagent provided with an effective calibration curve result, a number of remaining tests, and an expiration date of a reagent.Type: GrantFiled: March 19, 2012Date of Patent: December 6, 2016Assignee: Hitachi High-Technologies CorporationInventors: Masaki Shiba, Masaaki Hanawa, Masaharu Nishida, Hitoshi Otake
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Publication number: 20150330878Abstract: Herewith disclosed is a sample analyzer comprising: a measurement section configured to perform a measurement on a sample and generate a measurement value according to the concentration of an analyte in the sample; a memory storing a calibration curve; an analysis section; an output section; and an instruction receiver. When the instruction receiver receives an instruction to perform a diluting measurement on a calibration sample, the measurement section dilutes the calibration sample by a predetermined ratio and performs a measurement on the diluted calibration sample, and the analysis section determines the concentration of the analyte in the diluted calibration sample by applying a measurement value obtained from the diluted calibration sample to the calibration curve. Information generated based on the determined concentration and the known concentration is output.Type: ApplicationFiled: July 28, 2015Publication date: November 19, 2015Inventors: Masaki SHIBA, Tomoyuki NISHIDA, Yuji WAKAMIYA
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Patent number: 9151703Abstract: Herewith disclosed is a sample analyzer comprising: a measurement section configured to perform a measurement on a sample and generate a measurement value according to the concentration of an analyte in the sample; a memory storing a calibration curve; an analysis section; an output section; and an instruction receiver. When the instruction receiver receives an instruction to perform a diluting measurement on a calibration sample, the measurement section dilutes the calibration sample by a predetermined ratio and performs a measurement on the diluted calibration sample, and the analysis section determines the concentration of the analyte in the diluted calibration sample by applying a measurement value obtained from the diluted calibration sample to the calibration curve. Information generated based on the determined concentration and the known concentration is output.Type: GrantFiled: January 18, 2013Date of Patent: October 6, 2015Assignee: SYSMEX CORPORATIONInventors: Masaki Shiba, Tomoyuki Nishida, Yuji Wakamiya
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Publication number: 20150273464Abstract: A sample analyzer including a reagent reservoir configured to store a plurality of reagent containers; a first reagent dispenser configured to aspirate reagent of a first type from the reagent reservoir and dispense the aspirated reagent into a reaction container disposed at a first dispensing position; a second reagent dispenser configured to aspirate reagent of a second type from the reagent reservoir and dispense the aspirated reagent into a reaction container disposed at a second dispensing position; and a support member configured to support the first and the second reagent dispensers; wherein the first and the second reagent dispensers are supported by the support member so as to be movable independently of each other between each dispensing position and the reagent reservoir is disclosed. A sample analyzing method executed by a sample analyzer is also disclosed.Type: ApplicationFiled: March 26, 2015Publication date: October 1, 2015Inventors: Toshikatsu FUKUJU, Masanori IMAZU, Masaki SHIBA
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Publication number: 20140140890Abstract: The automatic analysis device measures time sequential data on a scattered light amount as reaction process data, and quantitatively determines the concentration of an analyte from a change in light amount. The automatic analysis device has a function of selecting reaction process data to be used for quantitative determination from the reaction process data obtained by measurement using a plurality of light receivers at different angles. As a result of using this function, data is selected from the reaction process data obtained by measurement using the plurality of light receivers at different angles in accordance with the concentration of the analyte and whether the priority is given to high sensitivity in the case where sensitivity is prioritized or a dynamic range, and the result of the quantitative determination is displayed.Type: ApplicationFiled: May 9, 2012Publication date: May 22, 2014Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Sakuichiro Adachi, Tomonori Mimura, Hajime Yamazaki, Masaki Shiba
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Publication number: 20130294974Abstract: A light source radiates light onto a reaction vessel in which a sample is caused to react with a reagent. A transmissive-light receiver, located across from the light source with the reaction vessel located therebetween, measures the intensity of transmissive light passing through the reaction vessel. Scattered-light receivers, located on the side of the transmissive-light receiver, are used to measure the intensities of scattered light and scattered light generated from the reaction vessel. Based on the results of the measurement by the scattered-light receivers, the light intensity of the light source is corrected. This allows correction of the intensity of the light incident on the reaction vessel even when an analysis involves the use of scattered light. The use of such analyzers prevents analysis results from varying from analyzer to analyzer due to inaccurate measurement of the incident light.Type: ApplicationFiled: November 29, 2011Publication date: November 7, 2013Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Masaki Shiba, Manabu Ando
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Publication number: 20130132022Abstract: An automatic analyzer is capable of reducing the influence of scattered light having noise components to enhance the S/N ratio properties of a light reception signal. Data is obtained at a plurality of angles by a plurality of detectors and a signal obtained by one detector selected from among the detectors is selected as a reference signal. An approximation is applied by an approximation selection unit, and an approximation calculation unit calculates an approximation using the selected approximation. A degree of variability of the reference signal is determined and a data correction unit corrects the signal of the detector by dividing the signal of the detector by the degree of variability of the reference signal. A concentration calculation processing unit performs the concentration calculation by use of the corrected signal data, and a result output unit outputs the results on a display.Type: ApplicationFiled: June 15, 2011Publication date: May 23, 2013Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Takuo Tamura, Masaki Shiba, Sakuichiro Adachi
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Publication number: 20130108509Abstract: Disclosed is an automatic analysis device including light detectors that detect scattered light, whereby highly reliable analysis results can be obtained by reduction of the effect of noise components. Highly reliable concentration analysis with little effect from noise components can be achieved by calculating the correlation between scattered light detected by a plurality of light detectors before calculating concentration, and by performing concentration analysis using scattered light with high correlation.Type: ApplicationFiled: June 13, 2011Publication date: May 2, 2013Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Masaki Shiba, Takuo Tamura, Sakuichiro Adachi
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Publication number: 20120183438Abstract: The automatic analyzer includes: a first reagent container storage section storing a plurality of reagent containers; a regent dispensing mechanism for dispensing a reagent from a reagent container stored in the first reagent container storage section; a second reagent container storage section storing a plurality of reagent containers; a reagent container transfer mechanism for transferring a reagent container selected from among reagent containers stored in the second reagent container storage section to the first reagent container storage section; and a controller configured to control the reagent container transfer mechanism to transfer a reagent container from the second reagent container storage section to the first reagent container storage section on the basis of a predetermined priority condition. The predetermined priority condition is one of a reagent provided with an effective calibration curve result, a number of remaining tests, and an expiration date of a reagent.Type: ApplicationFiled: March 19, 2012Publication date: July 19, 2012Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Masaki SHIBA, Masaaki HANAWA, Masaharu NISHIDA, Hitoshi OTAKE
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Patent number: 8158058Abstract: An automatic analyzer is disclosed that includes a supplementary reagent storage section and reagent bottle transfer mechanism besides an analysis reagent storage section, and that, by managing information on reagents stored in these two reagent storage sections, is capable of automating reagent management such as reagent replacing work, thereby reducing the burden on an operator, minimizing the interruption of an analysis due to reagent registration and reagent replacement, mounting many reagents thereon, and achieving a high throughput.Type: GrantFiled: May 13, 2004Date of Patent: April 17, 2012Assignee: Hitachi High-Technologies CorporationInventors: Masaki Shiba, Masaaki Hanawa, Masaharu Nishida, Hitoshi Otake
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Publication number: 20110104810Abstract: It is checked whether a liquid undulation prevention mechanism is present or absent in a reagent vessel at the start of an operation (steps 601 and 602). When the liquid leakage prevention mechanism is absent in the reagent vessel, the size of the opening of the reagent vessel is judged (step 604). A nozzle is inserted and lowered into the reagent vessel to judge the contact of the nozzle to the liquid surface. When the opening is larger size, a capacitance method is used (step 607). When the opening is small size, a pressure detection is used (step 608). When the liquid leakage prevention mechanism is present, the size of the opening is judged (step 604). When the opening is larger size, a capacitance method is used (step 605). When the opening is small size, a pressure detection is used (step 606).Type: ApplicationFiled: May 12, 2009Publication date: May 5, 2011Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Masaki Shiba, Tomonori Mimura, Yuko Hamazumi
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Patent number: 7776264Abstract: An automatic analyzer capable of replenishing a reagent even during an analysis and minimizing a suspension of the analysis. The automatic analyzer includes a plurality of reaction cells and a unit for holding reagents used in analyses. A plurality of reagents are dispensed to a sample in each reaction cell with a time difference to develop a reaction, and a liquid after the reaction is measured. After temporarily stopping the operation of dispensing the sample for a preset time during the analysis, the sample dispensing operation is restarted. Then, the sample dispensing operation is temporarily stopped again for the preset time at the timing in the dispensing of the reagent corresponding to the timing at which the sample dispensing operation was temporarily stopped. In the automatic analyzer, therefore, an analysis suspension due to registration and replacement of reagents during the analysis can be minimized, a larger number of reagents can be loaded, and a throughput per unit time can be increased.Type: GrantFiled: January 12, 2005Date of Patent: August 17, 2010Assignee: Hitachi High-Technologies CorporationInventors: Masaki Shiba, Hideyuki Yanami, Masaharu Nishida, Hitoshi Ohtake
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Patent number: 7749441Abstract: An automatic analyzer is disclosed that dispenses a sample and a reagent into each of a plurality of reaction vessels to allow them to react with each other, and that measures the liquid formed as a result of the reaction. This automatic analyzer includes a first reagent storage case for storing the reagent to be used for the reaction, a second reagent storage case for storing the reagent for supplemental purpose, and a reagent conveying unit for conveying the reagent from the second reagent storage case to the first reagent storage case.Type: GrantFiled: July 15, 2004Date of Patent: July 6, 2010Assignees: Hitachi High-Technologies Corporation, Roche Diagnostics Operations, Inc.Inventors: Masaaki Hanawa, Isao Yamazaki, Hitoshi Tokieda, Masaharu Nishida, Masaki Shiba, Heino Eikmeier, Dietmar Kappelhoff, Christoph Möllers, Stephan Sattler
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Publication number: 20050207938Abstract: An automatic analyzer is disclosed that dispenses a sample and a reagent into each of a plurality of reaction vessels to allow them to react with each other, and that measures the liquid formed as a result of the reaction. This automatic analyzer includes a first reagent storage case for storing the reagent to be used for the reaction, a second reagent storage case for storing the reagent for supplemental purpose, and a reagent conveying unit for conveying the reagent from the second reagent storage case to the first reagent storage case.Type: ApplicationFiled: July 15, 2004Publication date: September 22, 2005Inventors: Masaaki Hanawa, Isao Yamazaki, Hitoshi Tokieda, Masaharu Nishida, Masaki Shiba, Heino Eikmeier, Dietmar Kappelhoff, Christoph Mollers, Stephan Sattler
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Publication number: 20050175503Abstract: An automatic analyzer capable of replenishing a reagent even during an analysis and minimizing a suspension of the analysis. The automatic analyzer includes a plurality of reaction cells and a unit for holding reagents used in analyses. A plurality of reagents are dispensed to a sample in each reaction cell with a time difference to develop a reaction, and a liquid after the reaction is measured. After temporarily stopping the operation of dispensing the sample for a preset time during the analysis, the sample dispensing operation is restarted. Then, the sample dispensing operation is temporarily stopped again for the preset time at the timing in the dispensing of the reagent corresponding to the timing at which the sample dispensing operation was temporarily stopped. In the automatic analyzer, therefore, an analysis suspension due to registration and replacement of reagents during the analysis can be minimized, a larger number of reagents can be loaded, and a throughput per unit time can be increased.Type: ApplicationFiled: January 12, 2005Publication date: August 11, 2005Inventors: Masaki Shiba, Hideyuki Yanami, Masaharu Nishida, Hitoshi Ohtake
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Publication number: 20040253146Abstract: An automatic analyzer is disclosed that includes a supplementary reagent storage section and reagent bottle transfer mechanism besides an analysis reagent storage section, and that, by managing information on reagents stored in these two regent storage sections, is capable of automating reagent management such as reagent replacing work, thereby reducing the burden on an operator, minimizing the interruption of an analysis due to reagent registration and reagent replacement, mounting many reagents thereon, and achieving a high throughput.Type: ApplicationFiled: May 13, 2004Publication date: December 16, 2004Inventors: Masaki Shiba, Masaaki Hanawa, Masaharu Nishida, Hitoshi Otake
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Patent number: 6522976Abstract: An automatic analysis system that, even if one module out of a plurality of analysis modules becomes analysis-incapable, allows the analysis to be continued without stopping the entire system. The automatic analysis system has a plurality of analysis modules 5, 6, 7, and 8, and a transferring line 3 for transferring specimens to these analysis modules. During the analysis operation by the entire system, each analysis module is controllable as a standby state, namely, as a single-body analysis module in a state of being independent and being cut off from the control of the entire system.Type: GrantFiled: February 26, 2001Date of Patent: February 18, 2003Assignee: Hitachi, Ltd.Inventors: Masaki Shiba, Katsuaki Takahashi