Patents by Inventor Masaki Sunami
Masaki Sunami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080305169Abstract: [Problems] The present invention provides pharmaceutical composition which is effective for the prophylaxis or treatment of pathology showing involvement of uric acid (hyperuricemia, gouty tophus, acute gout arthritis, chronic gout arthritis, gouty kidney, urolithiasis, renal function disorder, coronary arterial disease, ischemic heart disease and the like) and the like, and is superior in the time-course stability and dissolution property (disintegration property). [Solving Means] The pharmaceutical composition of the present invention is a pharmaceutical composition comprising a nitrogen-containing fused ring compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable additives, wherein the nitrogen-containing fused ring compound or a pharmaceutically acceptable salt thereof is not in contact with a basic additive: wherein each symbol is as described in the specification.Type: ApplicationFiled: May 24, 2007Publication date: December 11, 2008Applicant: Japan Tobacco Inc.Inventors: Kazuki Miki, Fuyuki Arimoto, Masaki Sunami
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Publication number: 20060153913Abstract: The present invention relates to a solid formulation with improved solubility and maintained stability including a chemical substance poorly soluble in water as a pharmaceutically active ingredient formulated in an improved manner. More specifically, the present invention relates to a solid formulation having improved water-solubility which comprises a chemical substance poorly soluble in water as a pharmaceutically active ingredient, a water-soluble polymer substance and an inorganic porous substance, characterized in that (1) the chemical substance poorly soluble in water forms a solid dispersion together with the water-soluble polymer substance, (2) the water-soluble polymer substance forming the solid dispersion is in the form of fine pieces, and (3) the water-soluble polymer substance is in the form of fine pieces is maintained to be adsorbed on and/or adhered to the surface of the inorganic porous substance.Type: ApplicationFiled: October 24, 2005Publication date: July 13, 2006Inventors: Shogo Yamane, Hirofumi Yamane, Masaki Sunami
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Publication number: 20040225018Abstract: The invention provides pharmaceutical compositions comprising a cholesteryl ester transfer protein (CETP) inhibitor and a water-insoluble concentration-enhancing additive, which exhibit improved bioavailability. The invention also provides methods of treating cardiovascular disorders comprising the administration of the pharmaceutical compositions comprising a CETP inhibitor.Type: ApplicationFiled: March 17, 2004Publication date: November 11, 2004Applicant: Japan Tobacco Inc.Inventors: Masaki Sunami, Takanori Serigano
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Patent number: 5830497Abstract: Medicated plasters composed of a flexible support and a pressure-sensitive adhesive layer laminated thereon, in which said pressure-sensitive adhesive layer has an exposed surface with pH of 7 or higher and contains one of the following three components:i) a basic physiologically active agent and an acidic substance,ii) a salt of a basic physiologically active agent and a basic substance, andiii) a basic physiologically active agent and a salt of a basic physiologically active agent.Type: GrantFiled: May 29, 1996Date of Patent: November 3, 1998Assignee: Nitto Denko CorporationInventors: Akihito Yamanaka, Takashi Kinoshita, Masaki Sunami
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Patent number: 5368860Abstract: A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight %. Since the ratio of the amount of the undissolved local anesthetic (Ac) to that of the dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration of the present invention is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.Type: GrantFiled: November 26, 1991Date of Patent: November 29, 1994Assignee: Nitto Denko CorporationInventors: Masaki Sunami, Koji Maruyama, Mitsuhiko Hori, Shoichi Tokuda, Kenichiro Saito, Ikuo Kishi
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Patent number: 4937326Abstract: A novel reactive monoazo dye, which can give to cellulose fiber materials a deep orange to scarlet color superior in build-up property and chlorine fastness, represented by a free acid of the formula, ##STR1## wherein D is a phenyl group substituted with 1 to 3 substitutes selected from methyl, ethyl, methoxy, ethoxy, halogen, acetylamino, propionylamino, benzoylamino, succinylamino, maleinylamino, nitro, suflonic acid and carboxyl groups; R.sub.1 is a hydrogen atom, or a methyl or ethyl group; R.sub.2 is an alkyl group having 1 to 4 carbon atoms which is unsubstituted or substituted with a hydroxy, cyano, alkoxy, halogen, carboxy, alkoxycarbonyl or sulfonic acid group; Z is a hydrogen atom or a sulfonic acid group; A is a phenylene residue which is unsubstituted or substituted with 1 or 2 substituents selected from methyl, ethyl, methoxy, ethoxy, chlorine, bromine and sulfonic acid groups; or a naphthylene residue which is unsubstituted or substituted with one sulfonic acid group; and X is --SO.sub.2 CH.dbd.Type: GrantFiled: March 22, 1985Date of Patent: June 26, 1990Assignee: Sumitomo Chemical Company, LimitedInventors: Yutaka Kayane, Masaki Sunami, Katsumasa Otake, Yasuo Tezuka
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Patent number: 4720542Abstract: A formazan reactive blue dye represented by a free acid of the formula, ##STR1## wherein X.sub.1 and X.sub.2 are each a hydrogen atom, a methyl, methoxy or sulfonic acid group, m and l are each an integer of 0 or 1 and n is an integer of 0 to 2, provided that the sum of m, n and l is 2 or 3. This dye is usable for dyeing cellulose fibers in a brilliant blue color with good fastness, particularly, against chlorine, light and perspiration-light, as well as good white dischargeability.Type: GrantFiled: January 28, 1986Date of Patent: January 19, 1988Assignee: Sumitomo Chemical Company, LimitedInventors: Takashi Omura, Yasuo Tezuka, Masaki Sunami
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Patent number: 4663440Abstract: A brown reactive dye represented by a free acid of the formula, ##STR1## wherein R is a hydrogen atom or a C.sub.1 to C.sub.4 alkyl group, X is --SO.sub.2 CH.sub.2 CH.sub.2 Cl, --SO.sub.2 CH.dbd.CH.sub.2, --SO.sub.2 CH.sub.2 CH.sub.2 OSO.sub.3 H or --SO.sub.2 CH.sub.2 CH.sub.2 OPO.sub.3 H.sub.2, rings A, B and C are each a benzene or naphthalene ring which may have other substituent, m is 0 to 3 and n is 0 to 1.This dye is suitable for dyeing cellulose fibers brown to afford dyeings superior in fastnesses, acid stability, build-up property and level dyeing property.Type: GrantFiled: May 26, 1981Date of Patent: May 5, 1987Assignee: Sumitomo Chemical Company, LimitedInventors: Takashi Omura, Masaki Sunami, Yasuo Tezuka
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Patent number: 4412948Abstract: A bisazo reactive dye represented by a free acid of the formula, ##STR1## wherein X.sub.1 and X.sub.2 are each a hydrogen atom, a methyl or methoxy group, a chlorine atom, or a carboxylic acid or sulfonic acid group, Y is a hydrogen atom, a methyl or sulfonic acid group, Z is --CH.sub.2 CH.sub.2 OSO.sub.3 H, --CH.sub.2 CH.sub.2 OPO.sub.3 H.sub.2, --CH.sub.2 CH.sub.2 Cl or --CH.dbd.CH.sub.2, and Z.sub.1, Z.sub.2 and Z.sub.3 are each a hydrogen or chlorine atom, a methyl, methoxy, sulfonic acid or carboxylic acid group. This dye is usable for dyeing cellulose fibers in a deep blue color with good fastnesses, particularly, chlorine, light and perspiration-light fastnesses, a high acid stability, good white dischargeability as well as level dyeing properties.Type: GrantFiled: June 30, 1980Date of Patent: November 1, 1983Assignee: Sumitomo Chemical Company, LimitedInventors: Takashi Omura, Yasuo Tezuka, Masaki Sunami
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Patent number: 4384868Abstract: A reactive dye composition containing a dye mixture comprising 60 to 97 wt. % of C.I. Reactive Orange 16 and 40 to 3 wt. % of C.I. Reactive Orange 7, and 5 to 100 parts by weight per 100 parts by weight of said dye mixture of a naphthalenesulfonic acid/formaldehyde condensate having a sulfonation degree of 100 to 200%, which is very readily soluble in water and an aqueous alkaline solution and useful for dyeing cellulose fibers with a high color yield.Type: GrantFiled: March 9, 1982Date of Patent: May 24, 1983Assignee: Sumitomo Chemical Company, LimitedInventors: Masaki Sunami, Takemi Tokieda, Sadaharu Abeta
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Patent number: 4378313Abstract: The compounds represented, in the form of free acid, by the following general formula (I): ##STR1## (wherein A is ##STR2## (wherein R.sub.3 and R.sub.4 are each hydrogen or a methyl, ethyl, methoxy, ethoxy, acetylamino, propionylamino, benzoylamino or ureido group, and R.sub.5 and R.sub.6 are each hydrogen or a methyl or methoxy group), R.sub.1 and R.sub.2 are each hydrogen or a methyl, ethyl or sulfomethyl group, X.sub.1 and X.sub.2 are each hydrogen, chlorine or a methyl, methoxy, carboxyl or sulfonic acid group, m is a number of 0, 1 or 2, and n is a number of 1 or 2, provided that the sum of m and n is 1, 2 or 3).These compounds are capable of dyeing cellulose fibers in yellow with excellent color fastness to hypochlorite, light, perspiration and sunlight and high acid stability.Type: GrantFiled: May 27, 1980Date of Patent: March 29, 1983Assignee: Sumitomo Chemical Company, LimitedInventors: Yutaka Kayane, Masaki Sunami, Yasuo Tezuka
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Patent number: 4341699Abstract: A dye represented by a free acid of the formula, ##STR1## wherein A is ##STR2## in which Z is --CH.sub.2 CH.sub.2 OSO.sub.3 H or --CH.dbd.CH.sub.2. This dye is usable for dyeing cellulose fibers in brilliant red color with good fastness, particularly, too chlorine, light and perspiration-light and possesses level dyeing properties.Type: GrantFiled: July 7, 1980Date of Patent: July 27, 1982Assignee: Sumitomo Chemical Company, LimitedInventors: Yasuo Tezuka, Masaki Sunami, Takashi Omura, Yutaka Kayane