Patents by Inventor Masami Ezaki

Masami Ezaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic lipopeptide acylase
    Patent number: 6825003
    Abstract: The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: November 30, 2004
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Satoshi Ueda, Miho Tanaka, Masami Ezaki, Kazutoshi Sakamoto, Seiji Hashimoto, Nobutaka Oohata, Masaru Tsuboi, Michio Yamashita
  • Process for the deacylation of cyclic lipopeptides
    Patent number: 6573084
    Abstract: There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase. [wherein R1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: June 3, 2003
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Satoshi Ueda, Miho Tanaka, Masami Ezaki, Kazutoshi Sakamoto, Seiji Hashimoto, Nobutaka Oohata, Masaru Tsuboi, Michio Yamashita
  • Process for the deacylation of cyclic lipopeptides
    Patent number: 6537789
    Abstract: There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase. [wherein R1 is acyl; R2 is hydroxy or acyloxy; R3 is hydrogen or hydroxy; R4 is hydrogen or hydroxy; R5 is hydrogen or hydroxysulfonyloxy; and R6 is hydrogen or carbamoyl.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: March 25, 2003
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Satoshi Ueda, Miho Tanaka, Masami Ezaki, Kazutoshi Sakamoto, Seiji Hashimoto, Nobutaka Oohata, Masaru Tsuboi, Michio Yamashita
  • Compound, WF002, production thereof and use thereof
    Patent number: 6521600
    Abstract: The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprising the compound and pharmaceutically acceptable carrier, a use of the WF002 as a medicament and use of the compound for manufacture of the medicament for treatment of infectious disease.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: February 18, 2003
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Yasuhiro Hori, Masami Ezaki, Yasuhisa Tsurumi, Shigehiro Takase, Motohiro Hino
  • Cyclic lipopeptide acylase
    Publication number: 20020115133
    Abstract: The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase.
    Type: Application
    Filed: January 18, 2002
    Publication date: August 22, 2002
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Satoshi Ueda, Miho Tanaka, Masami Ezaki, Kazutoshi Sakamoto, Seiji Hashimoto, Nobutaka Oohata, Masaru Tsuboi, Michio Yamashita
  • Cyclic lipopeptide acylase
    Patent number: 6372474
    Abstract: The present invention provides a cyclic lipopeptide acrylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: April 16, 2002
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Satoshi Ueda, Miho Tanaka, Masami Ezaki, Kazutoshi Sakamoto, Seiji Hashimoto, Nobutaka Oohata, Masaru Tsuboi, Michio Yamashita
  • Process for the deacylation of cyclic lipopeptides
    Patent number: 6207434
    Abstract: There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: March 27, 2001
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Satoshi Ueda, Miho Tanaka, Masami Ezaki, Kazutoshi Sakamoto, Seiji Hashimoto, Nobutaka Oohata, Masaru Tsuboi, Michio Yamashita
  • Cyclic lipopeptide acylase
    Patent number: 6146872
    Abstract: The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase.
    Type: Grant
    Filed: December 31, 1998
    Date of Patent: November 14, 2000
    Assignee: Fukisawa Pharmaceutical Co., Ltd.
    Inventors: Satoshi Ueda, Miho Tanaka, Masami Ezaki, Kazutoshi Sakamoto, Seiji Hashimoto, Nobutaka Oohata, Masaru Tsuboi, Michio Yamashita
  • Antimicrobial agent, FR109615 and production thereof
    Patent number: 5514715
    Abstract: A method of killing pathogenic fungi by contacting them with an effective amount of (1R,2S)-2-aminocyclopentanecarboxylic acid (FR109615) or a salt thereof.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: May 7, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Michiyo Miyauchi, Eisaku Tsujii, Masami Ezaki, Seiji Hashimoto, Masakuni Okuhara
  • Process for producing WS-9326A and WS-9326B
    Patent number: 5436140
    Abstract: The novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof have useful pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain. A method for the production of the peptides WS-9326A and WS-9326B and derivatives thereof using Streptomyces violaceoniger No. 9326 in a biologically pure form is described herein.
    Type: Grant
    Filed: April 11, 1994
    Date of Patent: July 25, 1995
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Tohru Kino, Motoaki Nishikawa, Masami Ezaki, Sumio Kiyoto, Masakuni Okuhara, Shigehiro Takase, Satoshi Okada, Nobuharu Shigematsu
  • WS7622A mono- or di-sulfate, process for preparation thereof and use thereof
    Patent number: 5364624
    Abstract: A degenerative disease selected from the group consisting of cystic fibrosis, chronic bronchitis and bronchiectasia is treated by administering to a subject a therapeutically effective amount of WS7622A mono-or disulfate or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: November 15, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara
  • WS7622A mono- or di- sulfate, process for preparation thereof and use thereof
    Patent number: 5292510
    Abstract: WS7622A mono- or di-sulfate and pharmaceutically acceptable salts thereof. WS7622A exhibits human leukocyte elastase-inhibiting activity.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: March 8, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara
  • Prophylactic/therapeutic composition for disseminated intravascular coagulation, chronic respiratory tract infectious disease or chronic bronchitis
    Patent number: 5279826
    Abstract: A method for therapy of disseminated intravascular coagulation, or chronic respiratory tract infectious disease characterized by administering to a patient in need thereof an effective dose suitable for therapeutic treatment of said condition of WS7622A mono- or di-sulfate ester or their pharmaceutically acceptable salt.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: January 18, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Noriaki Inamura, Yasuhiko Shinguh, Kunio Nakahara, Yoshitada Notsu, Masanori Okamoto, Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Nobuharu Shigematsu, Masakuni Okuhara
  • Peptides WS-9326a and WS-9326b, derivatives thereof and uses thereof
    Patent number: 5217952
    Abstract: This invention relates to the novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof which have pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain.
    Type: Grant
    Filed: November 20, 1991
    Date of Patent: June 8, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Tohru Kino, Motoaki Nishikawa, Masami Ezaki, Sumio Kiyoto, Masakuni Okuhara, Shigehiro Takase, Satoshi Okada, Nobuharu Shigematsu
  • WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use for treatment of pulmonary emphysema and adult respiratory distress syndrome
    Patent number: 5167958
    Abstract: A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically acceptable salt.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: December 1, 1992
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara, Shigehiro Takase
  • Antimicrobial agent, FR109615 and production thereof
    Patent number: 5037809
    Abstract: (1R, 2S)-2-Aminocyclopentanecarboxylic acid and its salts useful as antimicrobial agents.
    Type: Grant
    Filed: January 26, 1990
    Date of Patent: August 6, 1991
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Michiyo Miyauchi, Eisaku Tsujii, Masami Ezaki, Seiji Hashimoto, Masakuni Okuhara
  • WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use thereof
    Patent number: 5021240
    Abstract: The present invention relates to new WS7622A, B, C and/or D substances, derivatives thereof and pharmaceutical compositions containing the new substances as active ingredients.
    Type: Grant
    Filed: February 21, 1990
    Date of Patent: June 4, 1991
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara, Shigehiro Takase
  • FR-900493 substance, a process for its production and a pharmaceutical composition containing the same
    Patent number: 4950605
    Abstract: FR-900493 is a compound of molecular formula C.sub.20 H.sub.33 N.sub.5 O.sub.11 which may be recovered from Bacillus cultures, possesses antimicrobial activity, and may be used for the treatment and prevention of infectious diseases in humans and animals.
    Type: Grant
    Filed: March 6, 1989
    Date of Patent: August 21, 1990
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kozo Ochi, Masami Ezaki, Morita Iwami, Tadaaki Komori, Masanobu Kohsaka
  • Amino acid derivatives of antitumor activity
    Patent number: 4939241
    Abstract: The invention relates to compounds of antitumor activity of the formula: ##STR1## ps in which R.sup.1 is hydrogen, lower allkyl, halo(lower)alkyl or aryl,R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen,R.sup.4 is aminocarboxy(lower)alkyl, protected amino(lower)alkyl or protected aminocarboxy(lower)alkyl, andR.sup.5 is hydrogen or lower alkyl, or its pharmaceutical acceptable salt.
    Type: Grant
    Filed: March 25, 1988
    Date of Patent: July 3, 1990
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Toshio Goto, Masami Ezaki, Miho Tanaka, Shigehiro Takase, Hidenori Nakajima, Hideo Hirai, Akira Katayama
  • New compound, FR-900451, production and use thereof
    Patent number: 4654211
    Abstract: Antibiotic FR-900451 is produced by Streptomyces griseorubiginosus No. 43708 (FERM BP-699).
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: March 31, 1987
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masami Ezaki, Seiji Hashimoto, Tadaaki Komori, Kazuyoshi Umehara, Masanobu Kohsaka