Patents by Inventor Masami Nakane

Masami Nakane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4632931
    Abstract: 7-Oxabicycloheptane substituted amide-sulfonamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is lower alkyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
    Type: Grant
    Filed: September 25, 1985
    Date of Patent: December 30, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Masami Nakane
  • Patent number: 4607048
    Abstract: 7-Oxabicycloheptane substituted aryl amino prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --; m is 1 to 8; n is 1 to 5; R is H, lower alkyl, alkali metal or a polyhydroxyamino salt; R.sup.1 is H, lower alkyl, hydroxyalkyl or aryl; R.sup.2 is H, lower alkyl, aryl or cycloalkyl, R.sup.3 is substituted aryl wherein the aryl group (which may be phenyl or naphthyl) is substituted with one or two of the following groups: hydroxy, ##STR2## SR.sup.4, --CN, --NO.sub.2, ##STR3## wherein R.sup.4 and R.sup.5 may be the same or different and are H or lower alkyl, and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: August 19, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Masami Nakane
  • Patent number: 4595692
    Abstract: Bicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein X is O or ##STR2## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
    Type: Grant
    Filed: May 17, 1985
    Date of Patent: June 17, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Masami Nakane
  • Patent number: 4588742
    Abstract: Thiabicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
    Type: Grant
    Filed: February 20, 1985
    Date of Patent: May 13, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Masami Nakane
  • Patent number: 4588741
    Abstract: 7-Thiabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal, glucamine salt or trihydroxymethylaminomethane salt, R.sup.1 is H (where X.noteq.O), lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, R.sup.2 is hydrogen or lower alkyl, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --, n is 1 to 4, and m is 1 to 8, and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: May 13, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Masami Nakane
  • Patent number: 4533673
    Abstract: 7-Oxabicycloheptane substituted enaminone prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: January 26, 1984
    Date of Patent: August 6, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Masami Nakane
  • Patent number: 4526901
    Abstract: 7-Oxabicycloheptane substituted oxamide prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: January 26, 1984
    Date of Patent: July 2, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Masami Nakane
  • Patent number: 4463015
    Abstract: 7-Oxabicycloheptane and prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: July 31, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Martin F. Haslanger, Masami Nakane
  • Patent number: 4456616
    Abstract: 7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Martin F. YHaslanger, Masami Nakane, Steven E. Hall
  • Patent number: 4456617
    Abstract: 7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: January 12, 1983
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Masami Nakane, Martin F. Haslanger
  • Patent number: 4456615
    Abstract: 7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Masami Nakane, David L. Snitman, Joyce Reid, Martin F. Haslanger
  • Patent number: 4418076
    Abstract: 7-Oxabicycloheptane hydrazone prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. pa The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: May 3, 1982
    Date of Patent: November 29, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Masami Nakane, Joyce Reid, Martin F. Haslanger
  • Patent number: 4416896
    Abstract: 7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: November 22, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Masami Nakane, David L. Snitman, Joyce Reid, Martin F. Haslanger
  • Patent number: 4139297
    Abstract: An electrophotographic copying apparatus incorporating therein an improved slit control device, which control device includes a blade member extending across the width of a photoreceptor drum. The width of the blade member in a direction normal to the axis of the photoreceptor drum is so arranged as to gradually increase toward its opposite ends in comparison with a generally uniform width in its central portion so as to form a slit which is wide in the central portion and gradually narrowed toward opposite ends, by which arrangement a sharp and definite image of an original is formed even on a photoreceptor drum of small diameter.
    Type: Grant
    Filed: May 23, 1977
    Date of Patent: February 13, 1979
    Assignee: Minolta Camera Kabushiki Kaisha
    Inventors: Masamichi Hayashi, Masami Nakane
  • Patent number: 4080057
    Abstract: An apparatus is provided for adjusting the exposure of the photoconductive member of an electrostatic copier, which permits fine adjustment of the exposure of the photoconductive member by providing a shade for the partial control of the light path for exposure, thereby effecting an error adjustment of the photoconductive member, the optical system, the projection lamp, etc., separately from the main exposure value control system.
    Type: Grant
    Filed: March 30, 1976
    Date of Patent: March 21, 1978
    Assignee: Minolta Camera Kabushiki Kaisha
    Inventors: Masami Nakane, Koji Imaizumi
  • Patent number: 4027965
    Abstract: A control mechanism for use in a photoelectrostatic copying machine utilizing a roll of recording medium as a source of material on which an image of the original to be copied is reproduced, which control mechanism controls the sequence of operation of various operating elements of the copying machine. The control mechanism for this purpose utilizes a rotatable cam assembly which, during rotation thereof through first and second predetermined angles, actuates first and second microswitches, respectively, which are electrically coupled to the feeder mechanism, illumination device and electrostatic charger and the drive unit for moving a transparent support structure for support of the original to be copied thereon. A third microswitch electrically coupled to the cutter unit may be actuated by either the cam assemby or an operating member adjustably carried by either of the transparent support structure and illumination device.
    Type: Grant
    Filed: April 28, 1975
    Date of Patent: June 7, 1977
    Assignee: Minolta Camera Kabushiki Kaisha
    Inventors: Yoshio Mikasa, Masami Nakane, Yukio Tokura