Patents by Inventor Masami Okuno

Masami Okuno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radioactive benzodiazepine derivatives
    Patent number: 5216147
    Abstract: The present invention relates to a novel radioactive benzodiazepine derivative represented by the formula: ##STR1## wherein R is hydrogen or a lower alkyl; X* is radioactive iodine or bromine; Y is hydrogen or a halogen; and Z is a halogen or nitro group; and the salt thereof.The compound of the present invention enables to non-invasively detect the presence of benzodiazepine receptors in human or animal brains, other organs or tissues. Additionally, it enables to dynamically trace the change in receptor concentration either. It is very useful as a radioactive diagnostic agent for nuclear medicine in vitro or in vivo or as a radiopharmaceutical.
    Type: Grant
    Filed: October 2, 1989
    Date of Patent: June 1, 1993
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Iwao Nakatsuka, Masami Okuno, Kunio Shiba, Akira Yoshitake
  • Novel radioactive propyl 2-iodospiroperidol and processes for the preparation thereof
    Patent number: 4945162
    Abstract: A radioactive propyl 2-iodospiroperidol of the formula: ##STR1## wherein I* is a radioactive iodine atom. The radioactive compound has a high affinity for dopamine receptors and is very useful as a radioactive diagnostic agent and as a radiopharmaceutical.
    Type: Grant
    Filed: December 4, 1987
    Date of Patent: July 31, 1990
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Iwao Nakatsuka, Masami Okuno
  • Radioactive benzodiazepine derivatives
    Patent number: 4885152
    Abstract: The present invention relates to a novel radioactive benzodiazepine derivative represented by the formula: ##STR1## wherein R is hydrogen or a lower alkyl; X* is radioactive iodine or bromine; Y is hydrogen or a halogen; and Z is a halogen or nitro group; and the salt thereof.The compound of the present invention enables to non-invasively detect the presence of benzodiazepine receptors in human or animal brains, other organs or tissues. Additionally, it enables to dynamically trace the change in receptor concentration either. It is very useful as a radioactive diagnostic agent for nuclear medicine in vitro or in vivo or as a radio-pharmaceutical.
    Type: Grant
    Filed: October 5, 1988
    Date of Patent: December 5, 1989
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Iwao Nakatsuka, Masami Okuno, Kunio Shiba, Akira Yoshitake
  • Radioactive and non-radioactive iodobutyrophenone derivative
    Patent number: 4739060
    Abstract: A radioactive or non-radioactive 2-iodobutyrophenone derivative the formula: ##STR1## wherein X is a radioactive or non-radioactive iodine atom. The radioactive compound has a high affinity for dopamine receptors and is very useful as a radioactive diagnostic agent and as a radiopharmaceutical, and the non-radioactive compound also as a high affinity for dopamine receptors and is very useful as a neuroleptic, a sedative, an anodyne, a tranquilizer, etc.
    Type: Grant
    Filed: August 14, 1986
    Date of Patent: April 19, 1988
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hideo Saji, Iwoa Nakatsuka, Masami Okuno, Akira Yokoyama