Abstract: A drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule includes a container body, a fusion-bonded portion which seals a mouth of the container body, and a wrench-off holder tab connected to the fusion-bonded portion. The ampoule is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption/adsorption preventing capability.

Abstract: The present invention provides a drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule (10) according to the present invention includes a container body (11), a fusion-bonded portion (13) which seals a mouth (12) of the container body, and a wrench-off holder tab (14) connected to the fusion-bonded portion. The ampoule (10) is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption/adsorption preventing capability.

Abstract: It is intended to provide a system which is safe to both of patients and medical staffs and by which medical accidents can be prevented. An admixture machine for infusion 1 has an information input unit for inputting predetermined information involving data concerning at least the body surface area, AUC or the body weight of the patient; a liquid delivery does calculation unit for determining the does of a liquid form drug and the amount of a diluent and calculating the delivery does of the liquid form drug and the diluent based upon the determined does; a guide unit for inserting a mixing tube which provides channels of the liquid form drug and the diluent; and liquid delivery units which deliver the liquid form drug and the diluent based on the delivery does of the liquid form drug and the diluent as determined in the liquid delivery does calculation unit.

Abstract: A multilayer sealant film for use in the medical field at least comprises as its innermost layer a first layer comprising at least one resin selected from the group consisting of linear low-density polyethylene, low-density polyethylene, polypropylene and polybutene-1, and a third layer comprising an ethylene-vinyl alcohol copolymer and laminated to the outer side of the first layer with a second layer serving as an adhesive layer and comprising a resin containing, as a main component, at least one of an amorphous polyolefin, adherent polyolefin and ethylene-vinyl acetate copolymer. The ethylene-vinyl alcohol copolymer forming the third layer functions as a barrier for preventing contaminants from migrating from outside of the third layer toward the first layer (innermost layer). Further, it is possible to improve the formability of the multilayer film since the difference in density between the resin for forming the first layer and the resin for forming the second layer is set to be 0.02 g/cm3 or less.

Abstract: A multilayer sealant film for use in the medical field at least comprises as its innermost layer a first layer comprising at least one resin selected from the group consisting of linear low-density polyethylene, low-density polyethylene, polypropylene and polybutene-1, and a third layer comprising an ethylene-vinyl alcohol copolymer and laminated to the outer side of the first layer with a second layer serving as an adhesive layer and comprising a resin containing, as a main component, at least one of an amorphous polyolefin, adherent polyolefin and ethylene-vinyl acetate copolymer. The ethylene-vinyl alcohol copolymer forming the third layer functions as a barrier for preventing contaminants from migrating from outside of the third layer toward the first layer (innermost layer). Further, it is possible to improve the formability of the multilayer film since the difference in density between the resin for forming the first layer and the resin for forming the second layer is set to be 0.02 g/cm3 or less.

Abstract: This invention provides a method for inhibiting adsorption of container-derived contaminants on a powdery or solid drug which comprises establishing a lower alcohol vapor phase within a container made, at least in part, of rubber or a plastic material. The method inhibits adsorption of container-derived substances on a drug to preclude development of insoluble particulate matter owing to said adsorption in an aqueous solution prepared extemporaneously without causing loss of the drug and avoiding the toxic effect of decomposition or degradation of the drug, thus insuring a long-term trouble-free stable shelf-life of the drug.

Abstract: The invention provides a polyolefin drug packaging material characterized in that the content, in the polyolefin, of substances containing 12 to 26 carbon atoms is not more than 150 ppm. The packaging material of the invention is useful because the risk of its reacting with and adversely affecting the drug packaged therewith is minimum.

Abstract: The invention presents an antithrombotic resin which is prepared by blending at least one type of antithrombotics, in polyurethane or polyurethane urea polymerized by using at least one type of polyether diol selected from the group consisting of polyol containing a polyoxyethylene group expressed in formula (I).paren open-st.CH.sub.2 CH.sub.2 O.paren close-st..sub.n (I)(where n is a number-average degree of polymerization of 1 to 100) and polyol containing a polyoxyethylene group expressed in formula (II).paren open-st.CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 O.paren close-st..sub.m(II)(where m is a number-average degree of polymerization of 1 to 100). This antithrombotic resin is capable of eluting the antithrombotic in the blood for a long time at high concentration. By using the antithrombotic resin of the invention, antithrombotic tube, antithrombotic film, antithrombotic coat, and others are obtained.

Abstract: The invention provides a method and a package form for insuring a stabilized bicarbonate-containing pharmaceutical composition, the method comprises filling the bicarbonate-containing powdery pharmaceutical composition in a moisture- and gas-permeable plastic container, wrapping the so-filled container in a moisture- and gas-impermeable plastic wrapper and carrying out at least one procedure selected from the group consisting of the procedure of introducing a carbon dioxide gas into a space between the container and wrapper, the procedure of disposing a carbon dioxide-liberating deoxygenating agent in the space and the procedure of disposing a desiccant previously saturated with carbon dioxide gas by way of adsorption in the space. In accordance with the invention, the inherent objects of incorporating the bicarbonate can be accomplished without inducing the aging and degradation of the bicarbonate-containing powdery pharmaceutical composition.

Abstract: A medical multilayer film chiefly for use in forming medical containers having a plurality of chambers comprises an inner layer, an intermediate layer and an outer layer each made primarily of a polyolefin, the inner layer being formed of resin mixture of an ethylene-alpha-olefin copolymer having a density of 0.930 to 0.945 g/cm.sup.3 and a polypropylene, the intermediate layer including at least one resin mixture layer of resin mixture of an ethylene-alpha-lefin copolymer having a density of 0.920 to 0.945 g/cm.sup.3 and an ethylene-alpha-olefin elastomer having a density of 0.880 to 0.890 g/cm.sup.3 in a mixing ratio by weight of 1:5 to 2:1, the resin mixture layer having a thickness of at least 85% of the overall thickness of the intermediate layer, the outer layer being formed of an ethylene-alpha-olefin copolymer having a density of 0.930 to 0.945 g/cm.sup.3.

Abstract: A container having a plurality of chambers chiefly for use in the field of medicine. The body of the container is made of flexible plastics and has partition means dividing the container body into the chambers and permitting communication between the chambers when required. At least one of the chambers is enclosed with a cover to form a closed space therein around the chamber. The cover is made of a flexible film having barrier properties against moisture and gas. The container is inexpensive, has high quality and is efficient to use and easy to dispose of.