Abstract: A hollow fiber membrane module (100) of the present invention includes: a plurality of hollow fiber membranes (10); a binding portion (20) binding the plurality of hollow fiber membranes (10) at one end portions thereof; and a cap (30) having an internal space (30s) that communicates with each of the plurality of hollow fiber membranes (10), the cap (30) being integrated with the binding portion (20); and a housing (40) that houses the plurality of hollow fiber membranes (10) and the binding portion (20), and that has one end portion to which the cap (30) is attached. A unit (70) including the plurality of hollow fiber membranes (10), the binding portion (20), and the cap (30) is detached from the housing (40) and the unit (70) is attached to the housing (40) while integration of the binding portion (20) and the cap (30) is maintained.

Abstract: A hollow fiber membrane module 100 includes: a plurality of hollow fiber membranes 10; a container 20 storing the plurality of hollow fiber membranes 10; and a feed water inlet 201 provided at one end portion of the container 20 such that a direction in which feed water flows into the container 20 is parallel to a longitudinal direction of the plurality of hollow fiber membranes 10. A permeation flux of the hollow fiber membranes 10 at a transmembrane pressure difference of 0.1 MPa is higher than or equal to 850 liter/m2/h.

Abstract: The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (R11 and R12 each independently represent a linear or branched C2-15 alkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and R3 and R4 each independently represent a C1-4 alkyl group or C2-4 alkenyl group, while R3 and R4 may form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R1)(R2)C(OH)—(CH2)a—(O—CO)b—X. (A): (R11)(R12)—CH—(CO—O)c—(CH2)v-. (B):—(CH2)d-N(R3)(R4).

Abstract: A composite semipermeable membrane includes a porous support membrane, a separation functional layer containing a polyamide disposed on the porous support membrane, and a coating layer disposed on the separation functional layer, wherein a water contact angle of a surface of the coating layer is 40° or less, and a protein adsorption force of the surface of the coating layer is 0.4 nN or less.

Abstract: A hollow fiber membrane module (100) of the present invention includes: a plurality of hollow fiber membranes (10); a binding portion (20) binding the plurality of hollow fiber membranes (10) at one end portions thereof; and a cap (30) having an internal space (30s) that communicates with each of the plurality of hollow fiber membranes (10), the cap (30) being integrated with the binding portion (20); and a housing (40) that houses the plurality of hollow fiber membranes (10) and the binding portion (20), and that has one end portion to which the cap (30) is attached. A unit (70) including the plurality of hollow fiber membranes (10), the binding portion (20), and the cap (30) is detached from the housing (40) and the unit (70) is attached to the housing (40) while integration of the binding portion (20) and the cap (30) is maintained.

Abstract: A hollow fiber membrane module 100 includes: a plurality of hollow fiber membranes 10; a container 20 storing the plurality of hollow fiber membranes 10; and a feed water inlet 201 provided at one end portion of the container 20 such that a direction in which feed water flows into the container 20 is parallel to a longitudinal direction of the plurality of hollow fiber membranes 10. A permeation flux of the hollow fiber membranes 10 at a transmembrane pressure difference of 0.1 MPa is higher than or equal to 850 liter/m2/h.