Patents by Inventor Masanao Shinohara

Masanao Shinohara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4831053
    Abstract: A prophylactic or therapeutic composition for hepatitis is disclosed comprising a prophylactically or therapeutically effective amount of a sesquiterpene compound represented by the formula (I) or (II) ##STR1## or a pharmaceutically acceptable salt thereof as an active ingredient, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: August 3, 1987
    Date of Patent: May 16, 1989
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Masanao Shinohara, Hirotsugu Kaise, Yoshimasa Nakano, Taketoshi Izawa, Yasuo Oshiro, Wasei Miyazaki
  • Patent number: 4545988
    Abstract: This invention provides a urokinase complex adsorbable by fibrin characterized in that it comprises heavy chain of high molecular weight urokinase as coupled with heavy chain of plasmin by one or more S-S bonds and a process for preparing the same.
    Type: Grant
    Filed: December 18, 1984
    Date of Patent: October 8, 1985
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Yasuo Nakayama, Wasei Miyazaki, Masanao Shinohara
  • Patent number: 4371524
    Abstract: A pharmaceutical composition having an anticomplementary activity comprising a therapeutically effective amount of at least one soyasapogenol B compound represented by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a group represented by the formula: ##STR2## wherein R.sup.2 represents a hydrogen atom or a hydroxymethyl group, R.sup.3 represents a hydrogen atom or a rhamnopyranosyl group, and R.sup.4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 6, 1981
    Date of Patent: February 1, 1983
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Masanao Shinohara, Yoshimasa Nakano, Hirotsugu Kaise, Taketoshi Izawa, Wasei Miyazaki
  • Patent number: 4229466
    Abstract: A sesquiterpene derivative expressed by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or a lower alkanoyl group; R.sup.2 and R.sup.3, which may be the same or different, each represents a formyl group, a hydroxymethyl group, a hydroxyl group, a carboxyl group, a lower alkanoyloxymethyl group, or a group of the formula --CH.dbd.CR.sup.7 R.sup.8, wherein R.sup.7 and R.sup.8, which may be the same or different, each represents a hydrogen atom, a cyano group, a lower alkoxycarbonyl group or a carboxyl group, or R.sup.2 and R.sup.3 may combine to form a lactone ring of the formula ##STR2## in which R.sup.9 represents a hydrogen atom or a hydroxyl group; R.sup.4 and R.sup.6, which may be the same or different, each represents a hydroxyl group or a lower alkanoyloxy group; R.sup.5 represents a hydrogen atom; R.sup.4 and R.sup.5 may together form an oxo group (.dbd.O); and R.sup.4 and R.sup.
    Type: Grant
    Filed: May 15, 1978
    Date of Patent: October 21, 1980
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Wasei Miyazaki, Hirotsugu Kaise, Yoshimasa Nakano, Taketoshi Izawa, Yasuo Oshiro, Masanao Shinohara
  • Patent number: 4217345
    Abstract: 3-0-(.beta.-D-Glucuronopyranosyl)-soyasapogenol B represented by the formula (I): ##STR1## and salts thereof and process for preparing the same are disclosed. The compound represented by the formula (I) and salts thereof have anticomplementary activity and are useful as therapeutic agents for autoimmune diseases, collagen diseases, and rheumatic diseases.
    Type: Grant
    Filed: March 30, 1979
    Date of Patent: August 12, 1980
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Masanao Shinohara, Yoshimasa Nakano, Hirotsugu Kaise, Taketoshi Izawa, Wasei Miyazaki