Patents by Inventor Masanobu Kawakami

Masanobu Kawakami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for reducing adverse effects of a human 70kDa mediator which results from endotoxin stimulation of macrophages
    Patent number: 6419927
    Abstract: Provided are therapeutic uses of antibodies capable of neutralizing the adverse effects in humans of the about 70 kDa mediator produced upon invasive stimulation of macrophages by, e.g., contact with endotoxin.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: July 16, 2002
    Inventors: Anthony Cerami, Masanobu Kawakami
  • Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay)
    Patent number: 6309640
    Abstract: Pharmaceutical compositions are provided which comprise neutralizing antibodies to the about 70 kDa mediator produced upon invasive stimulation of macrophages by, e.g., contact with endotoxin.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 30, 2001
    Assignee: The Rockefeller University
    Inventors: Anthony Cerami, Masanobu Kawakami
  • AC magnetic flux leakage flaw detecting apparatus for detecting flaws in flat surfaces with rotating leakage detection element
    Patent number: 5130652
    Abstract: An AC magnetic flux leakage type flaw detecting apparatus for use in flat surface flaw detecting comprises AC exciting means having a pair of magnetic poles for exciting a steel material to be flaw detected, a leakage magnetic flux detecting element, and rotatably scanning means for rotatably scanning the magnetic flux leakage detecting element in a surface substantially parallel to the flat surface oppositely to the flat surface to be flaw detected of the steel material in a plane of an exciting magnetic field between the pair of magnetic poles.
    Type: Grant
    Filed: November 20, 1989
    Date of Patent: July 14, 1992
    Assignee: Eddio Corporation
    Inventors: Masanobu Kawakami, Akio Kokubu
  • Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay)
    Patent number: 4822776
    Abstract: A mediator substance exhibiting inhibitory effect upon anabolic enzyme activity in mammals, is prepared by a method comprising gathering a sample of macrophage cells from a mammal, incubating a portion of the macrophage cells with a stimulating mateThis invention was made in the course of a grant from the National Institutes of Health.
    Type: Grant
    Filed: October 29, 1985
    Date of Patent: April 18, 1989
    Assignee: The Rockefeller University
    Inventors: Anthony Cerami, Masanobu Kawakami
  • Lipoprotein lipase suppression by endotoxin-induced mediator (shock assay)
    Patent number: 4603106
    Abstract: A mediator substance exhibiting inhibitory effect upon anabolic enzyme activity in mammals, is prepared by a method comprising gathering a sample of macrophage cells from a mammal, incubating a portion of the macrophage cells with a stimulating material that is associated with an invasive event, and inducing the macrophage cells to produce the mediator substance. The stimulator materials, for example, may include endotoxins, trypanosomes and the like, and the enzymes that may be observed range from lipoprotein lipase, acetyl Coenzyme A carboxylase and fatty acid synthetase, to the inducers for red blood cells growth and differentiation. The mediator substance may be utilized to raise antibodies which would in turn find utility in testing for the presence or amount of various invasive stimuli, such as infection and the like. Testing procedures and appropriate materials in kit form are also contemplated.
    Type: Grant
    Filed: September 7, 1982
    Date of Patent: July 29, 1986
    Assignee: The Rockefeller University
    Inventors: Anthony Cerami, Masanobu Kawakami