Patents by Inventor Masanobu Kohsaka
Masanobu Kohsaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120109072Abstract: There is provided a syringe capable of preventing the occurrence of “link-thread” from the distal end nozzle when the cap is pulled out, even in the case where the medicinal liquid filled has a high viscosity. The inner peripheral surface (631) of the seal cap (63) in the cap (6) is brought into close contact with the outer peripheral surface (214) of the distal end side portion of the distal end nozzle (21) in the barrel (2) so that the distal end opening (211) is hermetically closed off. At the same time, the outer peripheral side of the luer lock adapter (22) is covered with the outer tubular cover (62) of the cap. The bulge part (213) is formed in the distal end side portion of the inner aperture (212) in the distal end nozzle so that the aperture diameter (d) of the distal end opening is reduced to a small aperture diameter and, in addition, the length of seal (s) by the seal cap (63) is made to be a relatively short, predetermined length.Type: ApplicationFiled: August 24, 2009Publication date: May 3, 2012Applicants: Denki Kagaku Kogyo Kabushiki Kaisha, Taisei Kako Co LtdInventors: Kota Tabata, Masanobu Kohsaka, Kazutoshi Hioki, Ippei Matsumoto, Norihiko Asahi
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Publication number: 20100086788Abstract: Provided are a polyvinyl acetal sheet which is excellent in adhesion to glass, easy in control of adhesion, little colored, highly transparent and excellent in penetration resistance even under high-temperature conditions when the sheet is used for laminated glass or the like, a process for its production and a process for producing polyvinyl acetal particles used for the sheet. The polyvinyl acetal sheet is produced by molding polyvinyl acetal particles into a sheet with a degree of acetalization of from 75.0 to 84.0 mass % and with a porosity of from 60 to 85%. The polyvinyl acetal particles are preferably produced by an acetalization reaction of 100 parts by mass of a polyvinyl alcohol and from 40 to 75 parts by mass of an aldehyde in the presence of an acid catalyst at a reaction temperature of from 20 to 60° C.Type: ApplicationFiled: July 27, 2007Publication date: April 8, 2010Applicant: Denki Kagaku Kogyo Kabushiki KaishaInventors: Tsuyoshi Tsuji, Masanobu Kohsaka, Shigeharu Yoshii, Tomoo Saito, Yoshihiro Mashiko
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Patent number: 4950605Abstract: FR-900493 is a compound of molecular formula C.sub.20 H.sub.33 N.sub.5 O.sub.11 which may be recovered from Bacillus cultures, possesses antimicrobial activity, and may be used for the treatment and prevention of infectious diseases in humans and animals.Type: GrantFiled: March 6, 1989Date of Patent: August 21, 1990Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kozo Ochi, Masami Ezaki, Morita Iwami, Tadaaki Komori, Masanobu Kohsaka
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Patent number: 4906618Abstract: This invention relates to a method for promoting the growth of growing animals with compounds selected from WS-1627A; WS-1627B; WS-1627C and WS-1627D or salts thereof.Type: GrantFiled: February 19, 1987Date of Patent: March 6, 1990Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Seiji Hashimoto, Michio Yamashita, Kazuyoshi Umehara, Kiyohiko Kunugita, Masanobu Kohsaka
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Patent number: 4861774Abstract: The invention relates to a method for treatment of carcinoma or sarcoma tumor in mammals which comprises administering to said mammal an effective amount of a tetracyclo compound of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy, aryliminomethyl, hydroxyiminomethyl, alkoxyiminomethyl, acyloxyiminomethyl, semicarbazonomethyl or arylsemicarbazonomethyl,R.sup.2 is hydroxy, alkoxy, or protected hydroxy,R.sup.3 is hydrogen and R.sup.4 is methyl, hydroxymethyl or protected hydroxymethyl, orR.sup.3 and R.sup.4 are combined together to form methylene or oxo,R.sup.5 is hydroxy, alkoxy or protected hydroxy, andR.sup.6 is hydrogen, imino-protective group or alkyl,and pharmaceutically acceptable salts thereof.Type: GrantFiled: December 30, 1986Date of Patent: August 29, 1989Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masanobu Kohsaka, Hiroshi Terano, Tadaaki Komori, Morita Iwami, Michio Yamashita, Masashi Hashimoto, Itsuo Uchida, Shigehiro Takase
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Patent number: 4801580Abstract: The invention relates to novel peptides, of pharmacological activity, of the formula: ##STR1## wherein R.sup.1 is hydrogen,R.sub.b.sup.1 is methyl,R.sup.2 is carboxy, carboxymethylcarbamoyl, 1-carboxyethylcarbamoyl or ethoxycarbonylmethylcarbamoyl,R.sup.q is carboxy or 3-t-butoxycarbonylcarbazoyl,R.sup.p is carboxy or methoxycarbonyl,R.sup.r is hydrogen, t-butoxycarbonyl or benzyloxycarbonyl,m is the integer 2, andn is the integer 1, or its pharmaceutically acceptable salt.Type: GrantFiled: May 13, 1982Date of Patent: January 31, 1989Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
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Patent number: 4797417Abstract: The invention relates to novel furanone derivatives, having an aldose reductase-inhibitory activity, of the formula ##STR1## wherein A is a lower alkylene group,R.sup.1 is a carboxy, hydroxy, protected hydroxy or lower alkoxycarbonyl group,R.sup.2 is a hydrogen or halogen atom or a halo (lower) alkyl group, andR.sup.3 is a hydrogen atom or a hydroxy, carboxy, lower alkoxy or lower alkoxycarbonyl group.Type: GrantFiled: March 27, 1987Date of Patent: January 10, 1989Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masanori Okamoto, Itsuo Uchida, Kazuyoshi Umehara, Masanobu Kohsaka, Hiroshi Imanaka
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Patent number: 4782088Abstract: The invention relates to compounds of antihypertensive and antithrombotic activity of the formula or its pharmaceutically acceptable salt: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, or lower alkoxyphenyl,R.sup.2 is hydrogen or lower alkyl,R.sup.4 is lower alkyl,R.sup.6 is hydrogen or lower alkyl,R.sup.7 is lower alkyl which is optionally substituted by hydroxy or lower alkanoyloxy, andR.sup.10 is hydrogen or lower alkyl which is optionally substituted by carboxy or esterified carboxy.Type: GrantFiled: December 29, 1986Date of Patent: November 1, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masanori Okamoto, Morita Iwami, Shigehiro Takase, Itsuo Uchida, Kazuyoshi Umehara, Masanobu Kohsaka, Hiroshi Imanaka
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Patent number: 4778804Abstract: New nitro aliphatic compounds and their pharmaceutically acceptable salts are disclosed.Type: GrantFiled: October 11, 1985Date of Patent: October 18, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masanori Okamoto, Morita Iwami, Shigehiro Takase, Itsuo Uchida, Kazuyoshi Umehara, Masanobu Kohsaka, Hiroshi Imanaka
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Patent number: 4767768Abstract: New Nitro aliphatic compounds and their pharmaceutically acceptable salts are disclosed.Type: GrantFiled: December 8, 1983Date of Patent: August 30, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masanori Okamoto, Morita Iwami, Shigehiro Takase, Itsuo Uchida, Kazuyoshi Umehara, Masanobu Kohsaka, Hiroshi Imanaka
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Patent number: 4749691Abstract: The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R.sup.1 is hydroxyalkanoyl,R.sup.2 and R.sup.q are each hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy, R.sup. 2 is hydrogen or lower alkyl; R.sup.p is hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy or a group of the formula: ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above; R.sup.r is hydrogen or amino protective group; m is an integer 1 to 3;or its pharmaceutically acceptable salt.Type: GrantFiled: April 13, 1987Date of Patent: June 7, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
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Patent number: 4743555Abstract: A biologically pure culture of Streptomyces sandaensis which is capable of producing an antitumor and antimicrobial compound, designated FR-900482 substance, is disclosed.Type: GrantFiled: September 30, 1986Date of Patent: May 10, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masanobu Kohsaka, Hiroshi Terano, Tadaaki Komori, Morita Iwami, Michio Yamashita, Masashi Hashimoto, Itsuo Uchida, Shigehiro Takase
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Patent number: 4743614Abstract: Novel compounds of the following formula have restorative pharmacological activities in immuno-deficient hosts, ##STR1## wherein R.sup.1 is amino or a protected amino group,R.sup.2 is hydrogen, carboxy or a protected carboxy group,R.sup.3 is hydrogen, carboxy or a protected carboxy group,R.sup.4 is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, carbamoyl(lower)alkyl or protected carbamoyl(lower)alkyl,R.sup.5 is hydrogen or lower alkyl, andR.sup.6 is hydrogen, hydroxyphenyl(lower)alkyl, imidazolyl(lower)alkyl or indolyl(lower)alkyl.Type: GrantFiled: March 4, 1986Date of Patent: May 10, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroshi Terano, Yasuhisa Tsurumi, Hiroyuki Setoi, Masashi Hashimoto, Masanobu Kohsaka
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Patent number: 4725582Abstract: The invention concerns peptides, having the pharmaceutical property of enhancing the immune response, having the structure: ##STR1## wherein R.sup.1 is alkanoyl,R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl,R.sup.2 is hydrogen, carboxy, protected carboxy or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety is substituted by hydroxy or not substituted,R.sub.b.sup.2 is hydrogen or lower alkyl,R.sup.p is hydrogen, carboxy or protected carboxy,R.sup.q is carboxy, protected carboxy or a group of the formula ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above, R.sup.r is hydrogen or amino protective group,m is an integer 1 to 3, andn is an integer 1.Type: GrantFiled: May 13, 1982Date of Patent: February 16, 1988Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Takeno Hidekazu, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
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Patent number: 4680178Abstract: The invention relates to a pharmaceutical composition for treating lymphocytic leukemia, melanoma or mammary carcinoma comprising an effective amount of FR-900216.Type: GrantFiled: July 16, 1984Date of Patent: July 14, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Sumio Kiyoto, Masakuni Okuhara, Eiko Kino, Hirokazu Tanaka, Hatsuo Aoki, Masanobu Kohsaka, Hiroshi Imanaka
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Patent number: 4670259Abstract: The invention relates to a new compound, designated FR-68504. The compound has antitimor activities and is effective in the treatment of various tumors in both human beings and animals.There is also provided a process for preparing FR-68504 compound which comprises culturing a FR-68504 producing strain belonging to the genus Amauroascus in a nutrient medium.Pharmaceutical composition comprising FR-68504 as an active ingredient is also described.Type: GrantFiled: December 24, 1985Date of Patent: June 2, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Sumio Kiyoto, Hidetsugu Murai, Yasuhisa Tsurumi, Hiroshi Terano, Masanobu Kohsaka
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Patent number: 4666890Abstract: The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R.sup.1 is alkanoyl;R.sup.2 and R.sup.q are each hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy,R.sub.b.sup.2 is hydrogen or lower alkyl;R.sup.P is hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy or a group of the formula: ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above; R.sup.r is hydrogen or amino protective group;m is an integer 1 to 3;or its pharmaceutically acceptable salt.Type: GrantFiled: May 20, 1982Date of Patent: May 19, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
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Patent number: 4661352Abstract: This invention relates to a biologically active WS-7739-A substance and a biologically active WS-7739-B substance which have pharmacological activities and are useful for the treatment of asthma, thrombosis and the alike.Type: GrantFiled: October 19, 1984Date of Patent: April 28, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Motoaki Nishikawa, Morita Iwami, Keizo Yoshida, Masanobu Kohsaka
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Patent number: 4654211Abstract: Antibiotic FR-900451 is produced by Streptomyces griseorubiginosus No. 43708 (FERM BP-699).Type: GrantFiled: November 30, 1984Date of Patent: March 31, 1987Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masami Ezaki, Seiji Hashimoto, Tadaaki Komori, Kazuyoshi Umehara, Masanobu Kohsaka
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Patent number: RE32992Abstract: The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. Included is the peptide FR900156 having the structure: ##STR1## as well as the peptides of the structure ##STR2## wherein R.sup.1 is acyl;R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl;R.sup.2 is hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR3## wherein R.sub.a.sup.2 is mono- or di-carboxy lower alkyl or ar(carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy,R.sub.b.sup.2 is hydrogen or lower alkyl;R.sup.p and R.sup.q are each hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy;R.sup.r is hydrogen or amino protective group; m is an integer 1 to 3, and n is 1 .Iadd.provided that when R.sup.1 is benzyloxycarbonyl R.sub.5.sup.1 is methyl, m is an integer 2 and n is an integer 1, then R.sup.Type: GrantFiled: May 18, 1984Date of Patent: July 18, 1989Assignee: Fujisawa Pharaceutical Co., Ltd.Inventors: Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka, Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto