Abstract: Although compounds for treating or ameliorating malignant diseases have been proposed, patients had to endure a large burden since many of such compounds could not be orally ingested. Mangiferin has an effect of ameliorating malignant diseases through oral ingestion. However, such effect is minor and realistically it was not easy to ingest mangiferin. Further, in order to develop more effective pharmaceutical agents and the like for treating malignant diseases, it has been considered constantly necessary to obtain new or improved forms of an existing medical agent for inhibiting kinases such as NIK. Compounds represented by formula (1), formula (2), formula (3), formula (4), formula (5), formula (6), formula (7), formula (8), formula (9), formula (10), formula (11), and formula (12) have an effect of ameliorating malignant diseases through oral ingestion, and can exhibit said effect with an amount less than that for mangiferin.

Abstract: [Problem] COVID-19 caused by coronavirus SARS-CoV-2, cytokine release syndrome, cytokine release syndrome with CAR (chimeric antigen receptor)-T therapy, sepsis, systemic inflammatory response syndrome, hemophagocytic syndrome, macrophage activation syndrome, influenza, GVHD, systemic vasculitis, Kawasaki disease, Takayasu arteritis, and other diseases, if severe, can cause acute respiratory distress syndrome, disseminated intravascular coagulation syndrome, acute circulatory insufficiency, multi-organ failure, and other symptoms which are one of the causes of death. [Solution to Problem] Compounds represented by formulas (1) to (4) are effective when taken orally and can be expressed in smaller amounts than mangiferin.

Abstract: A region of a drug to be identified is detected from a captured image generated by imaging the drug to be identified that is imparted with engraved mark and/or print. The region of the drug to be identified in the captured image is processed to acquire an engraved mark and print extraction image that is an extracted image of the engraved mark and/or print of the drug to be identified. The engraved mark and print extraction image is input, and a drug type of the drug to be identified is inferred to acquire a candidate of the drug type of the drug to be identified.

Abstract: There is provided a medicine management system capable of checking a receipt status and a dosage stage of delivered medicines even at a delivery source. The medicine management system includes a management server for managing a receipt status and a dosage status of medicines to be delivered, a first terminal having a function of notifying the management server of information indicating receipt of medicines when the medicines have been received, a second terminal having a function of notifying the management server of information indicating dosage of medicines when the medicines have been taken, and a third terminal having a function of acquiring from the management server and displaying information on a receipt status and a dosage status of medicines.

Abstract: Provided are a drug recognizing apparatus, a drug recognizing method, and a drug recognizing program capable of enhancing robustness of a master image in a case where a drug is recognized. The drug recognizing apparatus includes an illumination unit that illuminates a drug; an imaging unit that images the illuminated drug; a storage unit that stores a master image for each drug type; a drug position acquiring unit that acquires a position of the drug on the basis of a captured image obtained by the imaging unit; a master image generating unit that generates the master image from a drug area in the captured image; an updating determination unit that determines whether to update the master image on the basis of the position of the drug acquired by the drug position acquiring unit; and a registration unit that registers the master image in the storage unit in a case where it is determined that the master image is to be updated.

Abstract: To provide a medicine collation device, a medicine collation system, a medicine management method, and a program, capable of collecting medicine images that are candidates for master images. The medicine collation device includes: a medicine image acquiring unit configured to acquire a medicine image generated by imaging a medicine to be collated; a first master image storing unit configured to store a master image of the medicine; a collating unit configured to collate the medicine image with the master image; an associating unit configured to associate the medicine image collated by the collating unit, with identification information on the medicine image; and a transmitting unit configured to transmit the medicine image and the identification information that are associated in the associating unit, to an outside.

Abstract: There is provided a medicine management system capable of checking a receipt status and a dosage stage of delivered medicines even at a delivery source. The medicine management system includes a management server for managing a receipt status and a dosage status of medicines to be delivered, a first terminal having a function of notifying the management server of information indicating receipt of medicines when the medicines have been received, a second terminal having a function of notifying the management server of information indicating dosage of medicines when the medicines have been taken, and a third terminal having a function of acquiring from the management server and displaying information on a receipt status and a dosage status of medicines.

Abstract: A medicine inspection support device, an image processing device, an image processing method and a program are provided that appropriately recognize identification information irrespective of whether the identification information is an engraved mark or a printed character. The image processing device obtains a plurality of taken images of a second medicine with light illumination directions to the surface of the second medicine different from each other, generates a first enhanced image by performing a process of enhancing an engraved mark portion of the second medicine, generates a second enhanced image by performing a process of enhancing a printed character portion of the second medicine, and collates the image designated by the designation information designating one of the first enhanced image and the second enhanced image as an image to be used for collation with the master image to determine whether the first medicine is identical to the second medicine.

Abstract: The present invention can ensure traceability of packaged drugs. A label printer of a drug packaging apparatus provided in a dispensing pharmacy or the like prints unique identification information, which is only one in the world issued by a numbering server on a package basis, on a label, and attaches the label to a packaging bag in which drugs are packaged by a drug packing unit. The dispensing pharmacy uploads at least drug information of the packaged drugs, to which the unique identification information is added, to a cloud server in association with the unique identification information. The cloud server unitarily manages the drug information of the packaged drugs uploaded from the dispensing pharmacy or the like in association with the unique identification information. The packaged drugs can be traced by making inquiries to the cloud server based on the unique identification information added to the packaging bag.

Abstract: Provided are a drug recognizing apparatus, a drug recognizing method, and a drug recognizing program capable of enhancing robustness of a master image in a case where a drug is recognized. The drug recognizing apparatus includes an illumination unit that illuminates a drug; an imaging unit that images the illuminated drug; a storage unit that stores a master image for each drug type; a drug position acquiring unit that acquires a position of the drug on the basis of a captured image obtained by the imaging unit; a master image generating unit that generates the master image from a drug area in the captured image; an updating determination unit that determines whether to update the master image on the basis of the position of the drug acquired by the drug position acquiring unit; and a registration unit that registers the master image in the storage unit in a case where it is determined that the master image is to be updated.

Abstract: A material for pressure measurement is provided, the material having a substrate made of plastic, a color forming agent layer containing a colorless electron-donating dye precursor and a color developing agent layer containing an electron-accepting compound, the material for pressure measurement forming a color utilizing a color forming reaction between the colorless electron-donating dye precursor and the electron-accepting compound, wherein the colorless electron-donating dye precursor is included in a microcapsule containing an urethane bond, wherein at least one kind of the electron-accepting compound is a metal salt of salicylic acid having a substituent, and wherein the microcapsule satisfies a relation ?/D=from 1.0×10?3 to 2.0×10?2, where ? is a number-average wall thickness (?m) of the microcapsules, and D is a median diameter (?m) of microcapsules on a volume basis.

Abstract: A material for pressure measurement is provided, the material having a substrate made of plastic, a color forming agent layer containing a colorless electron-donating dye precursor and a color developing agent layer containing an electron-accepting compound, the material for pressure measurement forming a color utilizing a color forming reaction between the colorless electron-donating dye precursor and the electron-accepting compound, wherein the colorless electron-donating dye precursor is included in a microcapsule containing an urethane bond, wherein at least one kind of the electron-accepting compound is a metal salt of salicylic acid having a substituent, and wherein the microcapsule satisfies a relation ?/D=from 1.0×10?3 to 2.0×10?2, where ? is a number-average wall thickness (?m) of the microcapsules, and D is a median diameter (?m) of microcapsules on a volume basis.

Abstract: The present invention aims to provide a pattern forming material that is capable of suppressing generation of wrinkles and static electric charge on a substrate in a lamination step in which the pattern forming material is laminated on the substrate as well as capable of forming a fine and precise pattern; a pattern forming apparatus provided with the pattern forming material; and a pattern forming process using the pattern forming material. To this end, the present invention provides a pattern forming material having a support, a photosensitive layer, and a protective film, the photosensitive layer and the protective film being formed in this order on the support, wherein the number of fish-eyes each having an area of 2,000?m2 or more and a maximum height measured from the film surface of 1?m to 7?m residing in the protective film is 50/m2 to 1,000/m2.

Abstract: An ink jet recording method that enables the recording of images which have a superior glossiness appropriate for production of photographic images, and which are especially superior in light fastness and ozone resistance. The image is formed on an ink jet recording medium by using an ink set, as the minimum constituent unit, having a yellow ink containing a yellow dye, a magenta ink containing a magenta dye, and a cyan ink containing a cyan dye, the magenta and cyan dyes having an oxidation potential of higher than 0.8 V (vs. SCE). The inkjet recording medium is heated and pressurized.

Abstract: The present invention provides a recording medium including a recording layer on a substrate, wherein the recording layer includes a polymer that has a thioether bond, has a sulfur equivalent of no less than 1.2 meq/g, and has an inorganic/organic ratio (I/O value) represented in an organic-inorganic conceptional diagram of no less than 0.5. According to the invention, the recording medium may be an ink jet recording medium, in which the recording layer is an ink receiving layer.

Abstract: An ink for ink jet recording, which hardly causes blotting of an image even under high humidity conditions while maintaining the advantages as water-based ink (handling properties, stability, producing properties, hue), is provided. Also provided is a method of manufacturing ink for ink jet recording, an ink set for ink jet recording, and an ink jet recording method.

Abstract: The objects of the present invention are to provide pattern forming materials capable of effectively suppressing sensitivity drop of photosensitive layers as well as capable of forming highly fine and precise patterns, pattern forming apparatuses equipped with the pattern forming materials, and pattern forming processes utilizing the pattern forming materials. In order to attain the objects, a pattern forming material is provided which comprises a support, and a photosensitive layer on the support, wherein the photosensitive layer comprises a polymerization inhibitor, a binder, a polymerizable compound, and a photopolymerization initiator, the photosensitive layer is exposed by means of a laser beam and developed by means of a developer to form a pattern, and the minimum energy of the laser beam is 0.1 mJ/cm2 to 10 mJ/cm2, which is required to yield substantially the same thickness of photosensitive layer subsequent to the developing as the thickness of the photosensitive layer prior to the exposing.

Abstract: The present invention aims to provide a pattern forming process which allows efficiently, highly precisely forming of a permanent pattern such as interconnection patterns and also allows achieving both tent property and resolution at high level. The pattern forming process includes laminating a photosensitive layer on a substrate to be processed in a pattern forming material which comprises at least the photosensitive layer, and exposing two or more arbitrarily selected regions in the photosensitive layer with light of a different amount of energy, wherein a laser beam emitted from a light irradiating unit having ‘n’ imaging portions receiving light from a light irradiating unit and outputting the light is modulated before the photosensitive layer is exposed with the laser beam through a microlens array in which microlenses each having a non-spherical surface capable of compensating the aberration due to distortion of output surfaces of the imaging portions are arrayed.

Abstract: The present invention aims to provide a pattern forming material that is capable of suppressing generation of wrinkles and static electric charge on a substrate in a lamination step in which the pattern forming material is laminated on the substrate as well as capable of forming a fine and precise pattern; a pattern forming apparatus provided with the pattern forming material; and a pattern forming process using the pattern forming material. To this end, the present invention provides a pattern forming material having a support, a photosensitive layer, and a protective film, the photosensitive layer and the protective film being formed in this order on the support, wherein the number of fish-eyes each having an area of 2,000 ?m2 or more and a maximum height measured from the film surface of 1 ?m to 7 ?m residing in the protective film is 50/m2 to 1,000/m2.

Abstract: A light-sensitive sheet comprises a support, a first light-sensitive layer and a second light-sensitive layer in this order. Each of the first and second light sensitive layers independently contains a binder, a polymerizable compound and a photo-polymerization initiator. The second light-sensitive layer is more sensitive to light than the first light-sensitive layer. A light-sensitive laminate comprises a substrate, the second light-sensitive layer and the first light-sensitive layer in this order.