Patent number: 8575153
Abstract: To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.
Type:
Grant
Filed:
November 27, 2009
Date of Patent:
November 5, 2013
Assignee:
Kowa Company, Ltd.
Inventors:
Takahiro Kitamura, Hajime Yamada, Shunji Takemura, Masanori Ashikawa, Tetsuya Ishikawa, Yoshiharu Miyake, Akiyasu Kouketsu, Seiichi Sato, Hiroyuki Ishiwata, Yuichiro Tabunoki, Manabu Shibasaki, Takatoshi Ozawa, Ryota Shigemi, Takeshi Doi, Masahiro Tamura
Publication number: 20110237590
Abstract: To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.
Type:
Application
Filed:
November 27, 2009
Publication date:
September 29, 2011
Inventors:
Takahiro Kitamura, Hajime Yamada, Shunji Takemura, Masanori Ashikawa, Tetsuya Ishikawa, Yoshiharu Miyake, Akiyasu Kouketsu, Seiichi Sato, Hiroyuki Ishiwata, Yuichiro Tabunoki, Manabu Shibasaki, Takatoshi Ozawa, Ryota Shigemi, Takeshi Doi, Masahiro Tamura
Publication number: 20100222347
Abstract: Disclosed is a low-molecular-weight compound having an EPO production-promoting activity and/or a hemoglobin expression-enhancing activity. Specifically disclosed is an EPO production promoter and/or a hemoglobin expression enhancer comprising a 1-acyl-4-(phenoxy, benzyloxy or phenylamino)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by the general formula (1); [wherein R1, R2, R2?, R3 and R3? independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or the like; A represents N—R11 or an oxygen atom; R11 represents a hydrogen atom, a C1-6 alkyl group, or the like; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.
Type:
Application
Filed:
September 29, 2008
Publication date:
September 2, 2010
Applicant:
KOWA COMPANY, LTD.
Inventors:
Masanori Ashikawa, Junya Tagashira, Akiyasu Koketsu, Toshiharu Morimoto, Tatsuaki Nishiyama, Satoshi Goda, Masaki Yamabi, Takeshi Doi, Hiroyuki Ishiwata