Patents by Inventor Masanori Funabashi

Masanori Funabashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of microbial synthesis of 4-ethylphenol and 4-ethylphenyl sulfate in behavior and disease
    Patent number: 11744867
    Abstract: Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.
    Type: Grant
    Filed: July 23, 2021
    Date of Patent: September 5, 2023
    Assignees: California Institute of Technology, The Regents of the University of California
    Inventors: Brittany D. Needham, Sarkis K. Mazmanian, Gil Sharon, Masanori Funabashi, Michael A. Fischbach, Elaine Y. Hsiao, Paul H. Patterson
  • MODULATION OF MICROBIAL SYNTHESIS OF 4-ETHYLPHENOL AND 4-ETHYLPHENYL SULFATE IN BEHAVIOR AND DISEASE
    Publication number: 20220096575
    Abstract: Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.
    Type: Application
    Filed: July 23, 2021
    Publication date: March 31, 2022
    Inventors: Brittany D. Needham, Sarkis K. Mazmanian, Gil Sharon, Masanori Funabashi, Michael A. Fischbach, Elaine Y. Hsiao, Paul H. Patterson
  • Modulation of microbial synthesis of 4-etylphenol and 4-ethylphenyl sulfate in behavior and disease
    Patent number: 11224624
    Abstract: Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: January 18, 2022
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Brittany D. Needham, Sarkis K. Mazmanian, Gil Sharon, Masanori Funabashi, Michael A. Fischbach, Elaine Y. Hsiao, Paul H. Patterson
  • MODULATION OF MICROBIAL SYNTHESIS OF 4-ETYLPHENOL AND 4-ETHYLPHENOL SULFATE IN BEHAVIOR AND DISEASE
    Publication number: 20190374588
    Abstract: Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.
    Type: Application
    Filed: February 13, 2018
    Publication date: December 12, 2019
    Inventors: Brittany D. Needham, Sarkis K. Mazmanian, Gil Sharon, Masanori Funabashi, Michael A. Fischbach, Elaine Y. Hsiao, Paul H. Patterson