Patents by Inventor Masanori Inamasu
Masanori Inamasu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5830873Abstract: A propiophenone derivative of the formula ?I!: ##STR1## wherein X is O, S or methylene, OY is a protected or unprotected OH, Z is .beta.-D-glucopyranosyl or 4-O-(.alpha.-D-glucopyranosyl)-.beta.-D-glucopyranosyl or wherein one or more hydroxy groups of these groups may optionally be acylated, and the dotted line means the presence or absence of a double bond, or a pharmaceutically acceptable salt thereof. Said compounds have excellent hypoglycemic activity so that they are useful in the prophylaxis or treatment of diabetes.Type: GrantFiled: April 27, 1995Date of Patent: November 3, 1998Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Kenji Tsujihara, Mitsuya Hongu, Nobuyuki Funami, Masanori Inamasu, Kenji Arakawa
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Patent number: 5731292Abstract: A method for prophylaxis or treatment of diabetes, which comprises administering to a patient with diabetes an effective amount of a dihydrochalcone derivative of the formula ?I!: ##STR1## wherein Ar is an aryl group, R.sup.1 is hydrogen atom or an acyl group, R.sup.2 is a hydrogen atom, an acyl group or .alpha.-D-glucopyranosyl group, or R.sup.1 and R.sup.2 may combine together to form a substituted methylene group, R.sup.3 and R.sup.4 are each a hydrogen atom or an acyl group, OR.sup.5 is a protected or unprotected hydroxy group or a lower alkoxy group, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 20, 1995Date of Patent: March 24, 1998Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Kenji Tsujihara, Mitsuya Hongu, Nobuyuki Funami, Masanori Inamasu, Kenji Arakawa
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Patent number: 5639789Abstract: Novel butadiene derivatives of the formula [I]: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R.sup.1 and R.sup.2 combine each other to form a group of the formula: ##STR2## or one of R.sup.1 and R.sup.2 is lower alkoxy, and the other is group of the formula: -NHR.sup.3, in which R.sup.3 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, hydroxy or pyridylcarbonyl, or salts thereof, these compounds have excellent antithrombotic activity and are useful as antithrombotic drug, or synthetic intermediate for preparing other antithrombotic drug.Type: GrantFiled: May 8, 1995Date of Patent: June 17, 1997Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Tameo Iwasaki, Takashi Nishitani, Akio Ohtani, Masanori Inamasu
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Patent number: 5514815Abstract: Novel succinimide derivatives of formula I!: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R.sup.1 and R.sup.2 combine each other to form a group of the formula:>N--R.sup.3or one of R.sup.1 and R.sup.2 is lower alkoxy, and the other is group of the formula: --NHR.sup.3, in which R.sup.3 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, hydroxy or pyridylcarbonyl, or salts thereof, these compounds have excellent antithrombotic activity and are useful as antithrombotic drug, or synthetic intermediate for preparing other antithrombotic drug.Type: GrantFiled: March 18, 1993Date of Patent: May 7, 1996Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Tameo Iwasaki, Takashi Nishitani, Akio Ohtani, Masanori Inamasu
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Patent number: 5424406Abstract: A method for treatment of diabetes, which comprises administering to a patient with diabetes an effective amount of a dihydrochalcone derivative of the formula: ##STR1## wherein Ar is an aryl group, R.sup.1 is a hydrogen atom or an acyl group, R.sup.2 is a hydrogen atom, an acyl group or .alpha.-D-glucopyranosyl group, or R.sup.1 and R.sup.2 may combine together to form a substituted methylene group, R.sup.3 and R.sup.4 are each a hydrogen atom or an acyl group, OR.sup.5 is a protected or unprotected hydroxy group or a lower alkoxy group; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 10, 1993Date of Patent: June 13, 1995Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Kenji Tsujihara, Mitsuya Hongu, Nobuyuki Funami, Masanori Inamasu, Kenji Arakawa
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Patent number: 4948900Abstract: Novel benzoxazole derivatives of the formula: ##STR1## wherein R is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted cycloalkyl group or a substituted or unsubstituted heterocyclic group; Alk is single bond, a substituted or unsubstituted lower alkylene group, a lower alkenylene group or a lower alkynylene group; the group is a group of the formula: --CH.sub.2 -- or --CH.dbd., and a pharmaceutically acceptable salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.Type: GrantFiled: November 13, 1989Date of Patent: August 14, 1990Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Masakatsu Ozeki, Kunihito Okumura, Masanori Inamasu
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Patent number: 4897393Abstract: Novel benzoxazole derivative of the formula: ##STR1## wherein R is a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a substituted or unsubstituted cycloalkyl group or a substituted or unsubstituted heterocyclic group; Alk is single bond, a substituted or unsubstituted lower alkylene group, a lower alkenylene group or a lower alkynylene group; the group ##STR2## is a group of the formula: --CH.sub.2 -- or --CH.dbd., and a pharmaceutically aceptable salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.Type: GrantFiled: March 14, 1988Date of Patent: January 30, 1990Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Masakatsu Ozeki, Kunihito Okumura, Masanori Inamasu
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Patent number: 4824833Abstract: Novel benzoxazine derivative of the formula: ##STR1## wherein R.sup.1 is phenyl group or a substituted thiazolyl group; R.sup.2 is hydrogen atom or a lower alkyl group; Q is single bond or a lower alkylene group, or a salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.Type: GrantFiled: March 14, 1988Date of Patent: April 25, 1989Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Ikuo Iijima, Masakatsu Ozeki, Kunihito Okumura, Masanori Inamasu
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Patent number: 4490392Abstract: A benzylalcohol derivative of the formula: ##STR1## wherein R is hydroxy, benzyloxy, halogen or alkoxy having one to four carbon atoms, and Ring A is monomethoxyphenyl, dimethoxyphenyl, trimethoxyphenyl or 3,4-methylenedioxyphenyl, or a pharmaceutically acceptable acid addition salt thereof is prepared by reducing a compound of the formula: ##STR2## wherein R' is benzyloxy, halogen or alkoxy having one to four carbon atoms, and Ring A is the same as defined above, to give a compound of the formula: ##STR3## wherein R' and Ring A are the same as defined above, and when R' is benzyloxy, if required, further subjecting the compound [I'] to catalytic hydrogenation to give a compound of the formula: ##STR4## wherein Ring A is the same as defined above. The benzylalcohol derivative [I] is useful as an anti-diabetic agent.Type: GrantFiled: July 27, 1978Date of Patent: December 25, 1984Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Muneyoshi Ikezaki, Takeshi Kanno, Hajime Iwai, Masanori Inamasu
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Patent number: 4276304Abstract: A benzylalcohol derivative of the formula: ##STR1## wherein R is hydroxy, benzyloxy, alkoxy of one to 4 carbon atoms or halogen, and Ring A is monomethoxyphenyl, dimethoxyphenyl, trimethoxyphenyl or 3,4-methylenedioxyphenyl is prepared by reducing a compound of the formula: ##STR2## wherein R' is benzyloxy, alkoxy of one to 4 carbon atoms or halogen, and Ring A is the same as defined above, and when R' is benzyloxy, if required, further subjecting the product to catalytic hydrogenation.The compounds (I) and pharmaceutically acceptable acid addition salts thereof are used as anti-diabetic agents.Type: GrantFiled: January 18, 1980Date of Patent: June 30, 1981Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Muneyoshi Ikezaki, Katsuyuki Noguchi, Hajime Iwai, Masanori Inamasu
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Patent number: 4218479Abstract: Racemic or optically active .alpha.-(2,3,4-trimethoxyphenethylaminomethyl)-2-hydroxybenzylalcohol [I] may be prepared by condensing 2,3,4-trimethoxyphenethylamine with 2-benzyloxyphenylglyoxal or its hydrate, reducing the resultant .alpha.(2,3,4-tri-methoxyphenethylimino)-2-benzyloxyacetophenone to give .alpha.(2,3,4-trimethoxyphenethylaminomethyl)-2-benzyloxybenzylalcohol, if required, resolving the 2-benzyloxybenzylalcohol derivative into each of its optically active enantiomers, and subjecting the racemic modification or optically active enantiomer of said 2-benzyloxybenzylalcohol derivative to catalytic hydrogenation. The compound [I] and pharmaceutically acceptable acid addition salts thereof are useful as anti-diabetic agents. They may be also used in the treatment of thrombosis.Type: GrantFiled: May 18, 1978Date of Patent: August 19, 1980Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Muneyoshi Ikezaki, Hisao Otsuka, Hajime Iwai, Masanori Inamasu, Takashi Morita