Abstract: Provided are a multi-fluorous blockmer using a readily available fluorous tag and capable of reducing burdens of purification, and an oligonucleotide synthesis method using the same. A multi-fluorous blockmer represented by the formula is synthesized: wherein B is a natural or modified nucleobase; R1 is a protecting group that can be removed for deprotection under acidic or neutral conditions; R3 is a protecting group for phosphate; Pro is unprotected, protected, or F-protector, wherein F-protector is O(CH2)n(CF2)mCF3 when the protected moiety of nucleoside base B is O, and is NH(C?O) (CH2)n(CF2)mCF3 when the protected moiety of nucleoside base B is N, wherein n is 1 or 2 and m is an integer of 1 to 20; X is O or S; l is an integer of 0 to 58; R7 is (C?O) (CH2)2(C?O) (CH2)n(CF2)mCF3 or a silyl protecting group, wherein n is 1 or 2 and m is an integer of 1 to 20.

Abstract: An optically active segment for use in synthesis of a stereocontrolled oligonucleotide represented by the following formula (I), a method for producing the same, and a method for synthesizing a stereocontrolled oligonucleotide therefrom are provided. In formula, B is a protected/unprotected nucleoside base; R1 is substituted/unsubstituted aliphatic group; R2, R3 is a DMTr group or —P(R11)(NR12)2; R11 is OCH2CH2CN, SCH2CH2CN, etc.; R12 is a substituted/unsubstituted aliphatic group or aromatic group; X is H, an alkyl, O-alkyl, etc.; Y is H, NHR13, a halogen, etc., or a hydroxyl group protected with an acyl, ether, or silyl, or forms an X—Y bond with X; and n is an integer of 0 or more and 4 or less.

Abstract: A segment for use in synthesis of an oligonucleotide, represented by the following formula (I), a method for producing the same, and a method for synthesizing an oligonucleotide therefrom are provided. In formula (I), B is a protected/unprotected nucleoside base; R1 is a protecting group; R2, R3 and R4 are OCH2CH2CN, OCH2CH?CH2, etc.; R5 is a substituted/unsubstituted aliphatic group/aromatic group; X is a lone pair, O or S; Y is NHR6, a halogen, CN, etc., or a hydroxyl group protected with an acyl, ether or silyl protecting group; R6 is H, an aliphatic group or an aromatic group; Z is H, an alkyl, an O- or N-alkyl or a halogen, or forms a Z—Y bond with Y; and (m+n) is an integer of 2 or more and 23 or less.

Abstract: The objective of the present invention is to provide a monomer for RNA synthesis which can be efficiently produced and therefore by which the producing cost of RNA can be remarkably decreased, and a method for efficiently producing the monomer in a small number of steps. In addition, the objective of the present invention is also to provide a method by which RNA can be efficiently produced even when a approximately stoichiometry amount of the monomer for RNA synthesis is used. The monomer for RNA synthesis according to the present invention is represented by the following formula (I) or (I?): wherein R1 is a protective group of the hydroxy group and R2 is an alkyl group or the like.

Abstract: The objective of the present invention is to provide a monomer for RNA synthesis which can be efficiently produced and therefore by which the producing cost of RNA can be remarkably decreased, and a method for efficiently producing the monomer in a small number of steps. In addition, the objective of the present invention is also to provide a method by which RNA can be efficiently produced even when a approximately stoichiometry amount of the monomer for RNA synthesis is used. The monomer for RNA synthesis according to the present invention is represented by the following formula (I) or (I?): wherein R1 is a protective group of the hydroxy group and R2 is an alkyl group or the like.

Abstract: A method for modifying nucleic acid bases by a chemical means, which enables the discrimination of every base species in plural species of bases in a nucleic acid comprising plural nucleotide units, while retaining the base sequence information of the nucleic acid. A nucleic acid base-modified product provided by the method. The nucleic acid base-modified product is essentially a single strand. In accordance with the invention, a novel means for sequencing a nucleic acid by a microscopic means is provided.

Abstract: The present invention provides artificial universal base capable of base pairing nonspecifically with any of four kinds of natural nucleic acid bases (A, T, G, and C) without the function to specifically recognize pairing natural nucleic acid bases for base pair formation. Universal base capable of base paring nonspecifically with four kinds of natural nucleic acid bases, wherein the universal base has a structure represented by the following chemical formula: wherein R represents a monovalent group other than a hydrogen atom.

Abstract: A terminal for performing multiple access transmission suitable to a transmission path having varied characteristics includes a transmission/reception section, a control unit, a transfer management section, and an external interface section. Specifically, the terminal refers to an IGMP (MLD) message received by the transmission/reception section to classify a transmitter host and a relay device of the message based on a characteristic of the transmission path, and performs a multiple access transmission of a multicast packet in a form suitable to the characteristic of the transmission path.

Abstract: A method for modifying nucleic acid bases by a chemical means, which enables the discrimination of every base species in plural species of bases in a nucleic acid comprising plural nucleotide units, while retaining the base sequence information of the nucleic acid. A nucleic acid base-modified product provided by the method. The nucleic acid base-modified product is essentially a single strand. In accordance with the invention, a novel means for sequencing a nucleic acid by a microscopic means is provided.

Abstract: The present invention provides artificial universal base capable of base pairing nonspecifically with any of four kinds of natural nucleic acid bases (A, T, G, and C) without the function to specifically recognize pairing natural nucleic acid bases for base pair formation. Universal base capable of base paring nonspecifically with four kinds of natural nucleic acid bases, wherein the universal base has a structure represented by the following chemical formula: wherein R represents a monovalent group other than a hydrogen atom.

Abstract: Provides a terminal for performing multiple access transmission suitable to a transmission path having varied characteristics. The terminal (100) includes a transmission/reception section (201), a control unit (204), a transfer management section (206), and an external interface section (203). The terminal (100) refers to an IGMP (MLD) message received by the transmission/reception section (201) to classify a transmitter host and a relay device of this message based on the characteristic of the transmission path, and performs a multiple access transmission of a multicast packet in a form suitable to the characteristic of the respective transmission path.

Abstract: A transport system composed of road side stations installed along roads and vehicles running on roads, wherein emergency processing at the time of an accident, a local information providing service, and so on are realized by the road side stations in cooperation of the road side stations and the respective vehicles. In the transport system, a plurality of road side stations are interconnected through a road side communication network, and a plurality of vehicles communicate with the road side stations. A vehicle transmits a request message containing a service code and location information. A road side station receiving the request message broadcasts the request message to the network. The road side stations receive the message, and determine whether or not requested processing should be executed based on the service code and the location information. When determining that the processing should be executed, the road side station executes processing indicated by the service code.

Abstract: The present invention relates to a distributed system in which processors incorporated in machines and objects are mutually linked in operation, and an object of the present invention is to provide a distributed system in which each device can establish a link with a suitable device according to changes in the environment and conditions, independently from the system configuration controlled by a server. In order to achieve the above object, each device provided by the present invention obtains information on surrounding devices through a sensor 131 or communication processing 112, recognizes the environment around it through environment recognition processing 111, and stores the environmental information in an environment management table 123. By employing link control processing 113, each device shares conditional information stored in a profile 122 and a policy 124 of each device through the communication processing 112.

Abstract: A client (referred to as A) transmits a request to a service mediate server (referred to as B) through a communication medium. B receives information. A server (referred to as C) receives a request for obtaining information from B and transmits information requested by B. B receives a request from A. A service mediate managing unit determines a type of information to be provided to A, based on the attribute information of the content of the request, the customized information of A and C pre-stored in the service mediate managing unit, and various status at the receipt of the request. The service mediate agent selects any one of plural Cs and transmit the request for obtaining information to the selected C. The information received by C is processed by the service mediate agent and the processed information is transmitted to A.

Abstract: The present invention provides a practical method capable of chemically synthesizing a 100-mer or more long-chain oligonucleotide easily and reliably and a novel compound used in said method. The present invention relates to a method for chemical synthesis of an oligonucleotide by the phosphoroamidite method, which comprises preparing a base moiety-unprotected nucleoside phosphoroamidite from a base moiety-unprotected nucleoside by use of an imidazole trifluoromethanesulfonate represented by the following chemical formula, and coupling said base moiety-unprotected nucleotide phosphoroamidite in a predetermined order to chemically synthesize an oligonucleotide consisting of a specific nucleotide sequence, as well as to an imidazole trifluoromethanesulfonate represented by the chemical formula.