Abstract: The present invention relates to a pharmaceutical composition containing a solid dispersion comprising an amide derivative or a salt thereof and a water-soluble polymer, wherein the pharmaceutical composition is not prepared by a melting method. The pharmaceutical composition contains the solid dispersion having an improved oral absorption, properties suitable for formulation, and an excellent stability.

Abstract: Liquid packs 34 provided with liquid leading members 42 are stored in a container case 31 that is constituted by fitting a case main body portion 32 and a lid case 33 in fitting portions 27 and 28, support portions 13, which positions the liquid leading members 42 so as to be opposed to liquid introducing members 71 attached to a cartridge inserting portion 13, are provided on a front surface 32a of the container case 31, the fitting portions 27 and 28 are arranged in a state in which the fitting portions 27 and 28 traverses the support portions 43, and space portions 29 and 30 having a gap larger than a gap formed in the fitting portions 27 and 28 are formed near the support portions 43 in the fitting portions 27 and 28. In this way, liquid flowing through the fitting portions 27 and 28 due to the capillarity is retained by the space portions 29 and 30 and never flows to the fitting portions 27 and 28 further extending from the space portions 29 and 30.

Abstract: Liquid packs 34 provided with liquid leading members 42 are stored in a container case 31 that is constituted by fitting a case main body portion 32 and a lid case 33 in fitting portions 27 and 28, support portions 13, which positions the liquid leading members 42 so as to be opposed to liquid introducing members 71 attached to a cartridge inserting portion 13, are provided on a front surface 32a of the container case 31, the fitting portions 27 and 28 are arranged in a state in which the fitting portions 27 and 28 traverses the support portions 43, and space portions 29 and 30 having a gap larger than a gap formed in the fitting portions 27 and 28 are formed near the support portions 43 in the fitting portions 27 and 28. In this way, liquid flowing through the fitting portions 27 and 28 due to the capillarity is retained by the space portions 29 and 30 and never flows to the fitting portions 27 and 28 further extending from the space portions 29 and 30.

Abstract: An engine including first scavenging passages for fluidly connecting between a combustion chamber and a crank chamber through bearings for the crankshaft, second scavenging passages fluidly connecting directly between the combustion chamber and the crank chamber, a suction chamber formed in a side face of a piston. An air-fuel mixture is sucked into the suction chamber and an air is introduced into the crank chamber. During the intake stroke, the air-fuel mixture from the air-fuel mixture passage is introduced into the first scavenging passages through the suction chambers, and the air is introduced into the crank chamber. During the scavenging stroke, before the air-fuel mixture in the first scavenging passages is introduced into the combustion chamber, introduction of the air in the crank chamber into the combustion chamber through the second scavenging passages starts.

Abstract: The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane protein having a hemagglutinin activity. This viral vector showed gene transfer at a high efficiency into host cells. In particular, it was established that genes can be transferred thereby at a high efficiency into cells into which genes can hardly be transferred by the conventional techniques, for example, blood cells and hematopoietic cells including hematopoietic stem cells, and mucous cells including mucosa epithelial cells. The viral vector of the present invention is highly useful as a vector for gene therapy.

Abstract: A cylinder block for the two-cycle combustion engine includes a scavenging port open at an inner peripheral surface of the cylinder block so as to orient diagonally upwardly relative to a longitudinal axis of a cylinder bore and defined in the cylinder block in communication with a combustion chamber. This scavenging port is formed by cutting with the rotary cutting tool, then rotated about its own longitudinal axis, from an inner peripheral surface of the cylinder block.

Abstract: A cylinder block includes a scavenging passage, which extends between a combustion chamber and a crankcase chamber to communicate them together and has a scavenging port defined in the cylinder block so as to open at an inner peripheral surface of the cylinder block. An intake passage or exhaust passage, the scavenging passage including the scavenging port and a throughhole defined therebetween are formed by the use of a molding piece movable in a direction towards the fuel intake passage or exhaust passage and the throughhole is closed by a lid.

Abstract: An image forming apparatus includes a member to be cleaned, and a cleaning member, formed by foam material having plural foam cells, that cleans the member to be cleaned by contacting the member to be cleaned and rubbing against the member to be cleaned. In any one of the plural foam cells in a surface of the cleaning member, a maximum length A in a rubbing direction and a maximum length B in a direction orthogonal to the rubbing direction satisfy the relationship of A<B.

Abstract: The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo.

Abstract: An optical scanning device including a light source, a deflection device to deflect a light beam from the light source, an image focus optical system to focus the light beam deflected by the deflection device on a scanned surface to form an image thereon and scan a surface by the light beam deflected by the deflection device to form an image thereon, a light path switching device provided between the light source and the deflection device, which switches a light path of the light beam emitted from the light source to deflect the light beam on different timings such that the light beam scans different surfaces.

Abstract: Liquid packs 34 provided with liquid leading members 42 are stored in a container case 31 that is constituted by fitting a case main body portion 32 and a lid case 33 in fitting portions 27 and 28, support portions 13, which positions the liquid leading members 42 so as to be opposed to liquid introducing members 71 attached to a cartridge inserting portion 13, are provided on a front surface 32a of the container case 31, the fitting portions 27 and 28 are arranged in a state in which the fitting portions 27 and 28 traverses the support portions 43, and space portions 29 and 30 having a gap larger than a gap formed in the fitting portions 27 and 28 are formed near the support portions 43 in the fitting portions 27 and 28. In this way, liquid flowing through the fitting portions 27 and 28 due to the capillarity is retained by the space portions 29 and 30 and never flows to the fitting portions 27 and 28 further extending from the space portions 29 and 30.

Abstract: In a liquid container in which a liquid container case accommodates at least three liquid storing packs under a condition that the liquid storing pack partially overlaps the adjacent liquid storing pack, amounts of liquid stored in the respective liquid storing packs have a plurality of levels, and the liquid pack storing the most amount of the liquid is arranged at parts other than the center of arrangement.

Abstract: A hermetic compressor has a hermetic container storing an oil, and a compressing element accommodated in the hermetic container and compressing a refrigerant gas; the compressing element has a compressing chamber, a cylinder forming the compressing chamber, a piston inserted into the cylinder and reciprocating, and a suction muffler (140) whose one end communicates with the compressing chamber; and the suction muffler (140) has a sound deadening space (142), a gas flow forming part (144) forming a gas flow (143) flowing in a constant direction in the sound deadening space (142), and an oil discharged opening (146) provided in a downstream side of the gas flow (143) in a lower part of the sound deadening space (142). By this constitution, there is realized the hermetic compressor in which the oil is more difficult to remain in the suction muffler (140), whose noise is lower, and whose performance is stabilized.

Abstract: To provide a muffler for a compact combustion engine, which is simple in structure and effective to sufficiently reduce the temperature of exhaust gases while avoiding contact with an external air, an exhaust guide passage 7 for communicating the exhaust gases (G) to a discharge port (63) is provided within an interior hollow of a muffler housing 6 defining an exhaust chamber (61) therein, and a side wall of this exhaust guide passage (7) is constituted by a portion (6W) of the muffler housing (6) and a duct wall (71) jointed to the muffler housing (6).

Abstract: The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo.

Abstract: To provide a two cycle combustion engine utilizing a connecting structure of a shape that can be formed inexpensively with a simple process to enable the efficiency of cooling of the cylinder block to be maintained at a high level and, also, that can firmly connect the cylinder block with the crankcase with fastening forces exerted by the fastening bolts, the two cycle combustion engine includes a crankcase 2 including first and second crank casings 2A and 2B that are split in a direction conforming to a crank axis C for operatively supporting a crankshaft 11, and a cylinder block 1 having a cylinder bore 1a defined therein and fixedly mounted atop the crankcase 2 by means of a plurality of fastening members 38 and 39 fitted in a direction upwardly from a crankcase-side.

Abstract: To provide a herbicidal composition which is highly safe to crop plants and which is capable of controlling weeds problematic in e.g. paddy fields, upland fields and non-agricultural fields over a wide range of from preemergence to postemergence.

Abstract: Liquid packs 34 provided with liquid leading members 42 are stored in a container case 31 that is constituted by fitting a case main body portion 32 and a lid case 33 in fitting portions 27 and 28, support portions 13, which positions the liquid leading members 42 so as to be opposed to liquid introducing members 71 attached to a cartridge inserting portion 13, are provided on a front surface 32a of the container case 31, the fitting portions 27 and 28 are arranged in a state in which the fitting portions 27 and 28 traverses the support portions 43, and space portions 29 and 30 having a gap larger than a gap formed in the fitting portions 27 and 28 are formed near the support portions 43 in the fitting portions 27 and 28. In this way, liquid flowing through the fitting portions 27 and 28 due to the capillarity is retained by the space portions 29 and 30 and never flows to the fitting portions 27 and 28 further extending from the space portions 29 and 30.