Patents by Inventor Masanori Okaniwa
Masanori Okaniwa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170044132Abstract: The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by formula (I) (in the formula, the symbols are as defined in the description) or a salt thereof.Type: ApplicationFiled: April 16, 2015Publication date: February 16, 2017Applicant: Takeda Pharmaceutical Company LimitedInventors: Takaharu HIRAYAMA, Jun FUJIMOTO, Douglas Robert CARY, Masanori OKANIWA, Yasuhiro HIRATA
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Publication number: 20170037057Abstract: The present invention provides a fused heterocyclic compound that has CDK 8 and/or CDK 19 inhibitory activity. The present invention provides a compound represented by formula (I) (wherein the symbols are as defined in the description) or a salt thereof.Type: ApplicationFiled: April 16, 2015Publication date: February 9, 2017Applicant: Takeda Pharmaceutical Company LimitedInventors: Masanori Okaniwa, Hiroshi BANNO, Takaharu HIRAYAMA, Douglas Robert CARY, Koji ONO, Naoki IWAMURA
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Patent number: 8697874Abstract: A compound represented by formula (I) or a salt thereof, which has a potent Raf inhibitory activity. In formula (I), R1 represents an optionally substituted C1-6 alkyl, etc.; X represents —O— or —NR2— (wherein R2 represents a hydrogen atom or a C1-6 alkyl); Y represents a group represented by formula 2 (2i or 2ii) (wherein ring A represents an optionally substituted benzene ring; Z represents a group represented by (1) —NR3CO—W1—, (2) —NR3CO—W1—O—, (3) —NR3CO—W1—O—W2—, (4) —NR3CO—W1—S—, (5) —NR3CO—W1—NR4—, (6) —NR3COO—, (7) —NR3COO—W1—, (8) —NR3CO—CO—, or (9) —NR3CONR4— (wherein R3 and R4 each represents a hydrogen atom, etc., and W1 and W2 each represents an optionally substituted C1-6 alkylene, etc.); and R5 represents an optionally substituted five- or six-membered ring group.Type: GrantFiled: November 30, 2009Date of Patent: April 15, 2014Assignee: Takeda Pharmaceutical Company LimitedInventor: Masanori Okaniwa
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Patent number: 8497274Abstract: Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.Type: GrantFiled: January 10, 2012Date of Patent: July 30, 2013Assignee: Takeda Pharmaceutical Company LimitedInventors: Masanori Okaniwa, Terufumi Takagi, Masaaki Hirose
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Patent number: 8344135Abstract: The present invention provides a heterocyclic compound having a strong Raf inhibitory activity, which is represented by the following formula wherein each substituent is as defined in the present specification, or a salt thereof.Type: GrantFiled: August 28, 2008Date of Patent: January 1, 2013Assignee: Takeda Pharmaceutical Company LimitedInventors: Masaaki Hirose, Masanori Okaniwa, Yoko Hayashi, Terufumi Takagi
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Patent number: 8324395Abstract: Provided is a heterocyclic compound showing strong Raf inhibitory activity. A compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.Type: GrantFiled: August 22, 2008Date of Patent: December 4, 2012Assignee: Takeda Pharmaceutical Company LimitedInventors: Masaaki Hirose, Masanori Okaniwa, Takashi Imada
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Publication number: 20120214855Abstract: Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.Type: ApplicationFiled: January 10, 2012Publication date: August 23, 2012Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Masanori OKANIWA, Terufumi TAKAGI, Masaaki HIROSE
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Patent number: 8143258Abstract: Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.Type: GrantFiled: December 1, 2009Date of Patent: March 27, 2012Assignee: Takeda Pharmaceutical Company LimitedInventors: Masanori Okaniwa, Terufumi Takagi, Masaaki Hirose
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Publication number: 20110237620Abstract: A compound represented by formula (I) or a salt thereof, which has a potent Raf inhibitory activity. In formula (I), R1 represents an optionally substituted C1-6 alkyl, etc.; X represents —O— or —NR2— (wherein R2 represents a hydrogen atom or a C1-6 alkyl); Y represents a group represented by formula 2 (2ii or 2ii) (wherein ring A represents an optionally substituted benzene ring; Z represents a group represented by (1) —NR3CO—W1—, (2) —NR3CO—W1—O—, (3) —NR3CO—W1—O—W2—, (4) —NR3CO—W1—S—, (5) —NR3CO—W1—NR4—, (6) —NR3COO—, (7) —NR3COO—W1—, (8) —NR3CO—CO—, or (9) —NR3CONR4— (wherein R3 and R4 each represents a hydrogen atom, etc., and W1 and W2 each represents an optionally substituted C1-6 alkylene, etc.); and R5 represents an optionally substituted five- or six-membered ring group.Type: ApplicationFiled: November 30, 2009Publication date: September 29, 2011Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventor: Masanori Okaniwa
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Publication number: 20110172245Abstract: Provided is a heterocyclic compound showing strong Raf inhibitory activity. A compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.Type: ApplicationFiled: August 22, 2008Publication date: July 14, 2011Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Masaaki Hirose, Masanori Okaniwa, Takashi Imada
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Patent number: 7842701Abstract: The present invention provides a pyarzoloquinolone derivative having kinase inhibitory activity. The derivative is represented by the formula: wherein R1 is an aryl group which may be substituted, or an aromatic heterocyclic group which may be substituted; R2 is a hydrogen atom, an amino group which may be substituted, a hydroxy group which may be substituted, or a thiol group which may be substituted; R3, R4, R5 and R6, which may be identical or different, are each (1) a hydrogen atom, (2) a nitro group, (3) a cyano group, (4) a halogen atom, (5) a hydrocarbon group which may be substituted, (6) an amino group which may be substituted, (7) a hydroxy group which may be substituted, or (8) a thiol group which may be substituted; and R3 and R4, R4 and R5, and R5 and R6 may respectively form a ring together with the adjacent carbon atom, or salt thereof.Type: GrantFiled: February 18, 2005Date of Patent: November 30, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Shoji Fukumoto, Takeshi Yamamoto, Masanori Okaniwa, Toshimasa Tanaka
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Publication number: 20100249119Abstract: The present invention provides a heterocyclic compound having a strong Raf inhibitory activity, which is represented by the following formula wherein each substituent is as defined in the present specification, or a salt thereof.Type: ApplicationFiled: August 28, 2008Publication date: September 30, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Masaaki Hirose, Masanori Okaniwa, Yoko Hayashi, Terufumi Takagi
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Publication number: 20100216810Abstract: Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.Type: ApplicationFiled: December 1, 2009Publication date: August 26, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Masanori OKANIWA, Terufumi TAKAGI
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Publication number: 20090163488Abstract: A compound represented by the formula (I): wherein Z1, Z2, Z3 and Z4 are the following combination, (Z1,Z2,Z3,Z4)=(CR4,N,CR5,C), (N,N,CR5,C), (N,C,CR5,N), (S,C,CR5,C) or (S,C,N,C); R1 and R2 are the same or different and each is (1) a hydrogen atom, (2) a halogen atom, (3) a group bonded via a carbon atom, (4) a group bonded via a nitrogen atom, (5) a group bonded via an oxygen atom or (6) a group bonded via a sulfur atom; R3 is an amino optionally having substituent(s); R4 and R5 are the same or different and each is (1) a hydrogen atom, (2) a halogen atom, (3) a group bonded via a carbon atom, (4) a group bonded via a nitrogen atom, (5) a group bonded via an oxygen atom or (6) a group bonded via a sulfur atom; R3 and R4 optionally form a ring optionally having substituent(s); and a group represented by the formula is a cyclic group optionally having substituent(s), or a salt thereof.Type: ApplicationFiled: June 4, 2008Publication date: June 25, 2009Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Yuya OGURO, Shinichi IMAMURA, Douglas R. CARY, Masanori OKANIWA
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Publication number: 20070281963Abstract: The present invention provides a pyarzoloquinolone derivative having kinase inhibitory activity. The derivative is represented by the formula: wherein R1 is an aryl group which may be substituted, or an aromatic heterocyclic group which may be substituted; R2 is a hydrogen atom, an amino group which may be substituted, a hydroxy group which may be substituted, or a thiol group which may be substituted; R3, R4, R5 and R6, which may be identical or different, are each (1) a hydrogen atom, (2) a nitro group, (3) a cyano group, (4) a halogen atom, (5) a hydrocarbon group which may be substituted, (6) an amino group which may be substituted, (7) a hydroxy group which may be substituted, or (8) a thiol group which may be substituted; and R3 and R4, R4 and R5, and R5 and R6 may respectively form a ring together with the adjacent carbon atom, or salt thereof.Type: ApplicationFiled: February 18, 2005Publication date: December 6, 2007Applicant: Takeda Pharmaceutical CompanyInventors: Shojl Fukumoto, Takeshi Yamamoto, Masanori Okaniwa, Toshimasa Tanaka