Abstract: The present invention relates to a synapse formation promoter and a brain plasticity promoter comprising CD24-negative mesenchymal stem cells prepared from a patient's own bone marrow aspirate and treatment of dementia, chronic-phase cerebral infarction, chronic-phase spinal cord injury, mental diseases, and the like using the synapse formation promoter and brain plasticity promoter.

Abstract: A road surface rendering device for rendering a road surface by illuminating an illumination region extending along a direction away from the road surface rendering device with light. The illumination region is divided into three regions of a left region, a central region, and a right region in a direction intersecting a longitudinal direction, an illuminance of the central region is largest.

Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Abstract: A tool system includes a portable tool, an image capturing unit, an orientation detection unit, and a processing unit. The tool includes a driving unit to be activated with power supplied from a power source. The image capturing unit is provided for the tool and generates a captured image. The orientation detection unit is provided for the tool and detects an orientation of the tool. The processing unit performs processing based on the captured image and the orientation.

Abstract: An automatic transmission includes a brake including a fixed-side cylindrical member spline-coupled to a transmission case, a rotation-side cylindrical member coupled to a given rotating member, a plurality of friction plates disposed between the fixed-side cylindrical member and the rotation-side cylindrical member, and including a fixed-side friction plate configured to be spline-engaged with the fixed-side cylindrical member and a rotation-side friction plate configured to be spline-engaged with the rotation-side cylindrical member, and a piston configured to engage the plurality of friction plates. The automatic transmission further includes a shock absorbing member disposed between a spline part of the transmission case and a spline part of the fixed-side cylindrical member and configured to absorb impact when the fixed-side cylindrical member rotates relative to the transmission case.

Abstract: The present invention relates to a synapse formation promoter and a brain plasticity promoter comprising CD24-negative mesenchymal stem cells prepared from a patient's own bone marrow aspirate and treatment of dementia, chronic-phase cerebral infarction, chronic-phase spinal cord injury, mental diseases, and the like using the synapse formation promoter and brain plasticity promoter.

Abstract: An automatic transmission is provided, which includes a brake including a fixed-side cylindrical member spline-coupled to a transmission case, a rotation-side cylindrical member coupled to a given rotating member, a plurality of friction plates disposed between the fixed-side cylindrical member and the rotation-side cylindrical member, and including a fixed-side friction plate configured to be spline-engaged with the fixed-side cylindrical member and a rotation-side friction plate configured to be spline-engaged with the rotation-side cylindrical member, and a piston configured to engage the plurality of friction plates. The automatic transmission includes a shock absorbing member disposed between a spline part of the transmission case and a spline part of the fixed-side cylindrical member and configured to absorb impact when the fixed-side cylindrical member rotates relative to the transmission case.

Abstract: The present invention relates to a pharmaceutical composition for treating amyotrophic lateral sclerosis. More specifically, the present invention relates to a pharmaceutical composition for treating amyotrophic lateral sclerosis, wherein the pharmaceutical composition comprises mesenchymal stem cells and is intravenously administered.

Abstract: The present invention relates to a pharmaceutical composition containing mesenchymal stem cells administered to a patient subjected to stenting. The present invention relates specifically to: a pharmaceutical composition for repairing and regenerating tissue, comprising mesenchymal stem cells, wherein the pharmaceutical composition is administered to a patient subjected to stenting; and the prevention of in-stent neointimal hyperplasia or in-stent restenosis with the pharmaceutical composition.

Abstract: An automatic transmission is provided, which includes a transmission case having a vertical wall part, a clutch disposed on a first side of the vertical wall part in an axial direction, a given component disposed on the second side of the vertical wall part, and a sleeve having a cylindrical body and a flange part coupled to the second side of the vertical wall part and disposed radially inward of the given component. The hydraulic fluid is supplied to the clutch from radially inward of the clutch through the vertical wall part. An oil supply passage is configured to supply the hydraulic fluid to the radially inward of the clutch through a first oil passage extending in the axial direction via a coupling part between the vertical wall part and the flange part, a second oil passage inside the flange part, and a third oil passage inside the cylindrical body.

Abstract: A power transmission device is provided, which includes a vibration reducing damper provided on a power transmission path, and a clutch mechanism having a plurality of friction plates, a hydraulic pressure chamber, and a centrifugal balance chamber provided opposed to the hydraulic pressure chamber. The clutch mechanism is provided adjacent to an axial side part of the damper, and an oil drain port for hydraulic fluid supplied to the centrifugal balance chamber of the clutch mechanism is provided at a location radially inward of the damper and axially overlapping with the damper.

Abstract: A power transmission device in an automatic transmission includes a friction tightening element (a second brake) having a drum member, and a transmission path constituent member (a third ring gear) coupled to the drum member via a coupling part extending circumferentially along the drum member, the drum member having low-rigidity parts (long holes) provided at a plurality of circumferential positions on the drum member in at least one of portions radially outside and inside the coupling part.

Abstract: A power transmission device is provided, which includes a vibration reducing damper provided on a power transmission path, and a clutch mechanism having a plurality of friction plates, a hydraulic pressure chamber, and a centrifugal balance chamber provided opposed to the hydraulic pressure chamber. The clutch mechanism is provided adjacent to an axial side part of the damper, and an oil drain port for hydraulic fluid supplied to the centrifugal balance chamber of the clutch mechanism is provided at a location radially inward of the damper and axially overlapping with the damper.

Abstract: An automatic transmission is provided, which includes a transmission case having a vertical wall part, a clutch disposed on a first side of the vertical wall part in an axial direction, a given component disposed on the second side of the vertical wall part, and a sleeve having a cylindrical body and a flange part coupled to the second side of the vertical wall part and disposed radially inward of the given component. The hydraulic fluid is supplied to the clutch from radially inward of the clutch through the vertical wall part. An oil supply passage is configured to supply the hydraulic fluid to the radially inward of the clutch through a first oil passage extending in the axial direction via a coupling part between the vertical wall part and the flange part, a second oil passage inside the flange part, and a third oil passage inside the cylindrical body.

Abstract: An electricity measuring type surface plasmon resonance sensor including: a plasmon polariton intensifying sensor chip in which a prism and a sensor chip including a transparent electrode, an n-type transparent semiconductor film, and a plasmon resonance film electrode arranged in this order are arranged in an order of the prism, the transparent electrode, the n-type transparent semiconductor film, and the plasmon resonance film electrode; and an electric measuring apparatus which directly measures a current or voltage from the transparent electrode and the plasmon resonance film electrode.

Abstract: A power transmission device in an automatic transmission includes a friction tightening element (a second brake) having a drum member, and a transmission path constituent member (a third ring gear) coupled to the drum member via a coupling part extending circumferentially along the drum member, the drum member having low-rigidity parts (long holes) provided at a plurality of circumferential positions on the drum member in at least one of portions radially outside and inside the coupling part.

Abstract: An electricity measuring type surface plasmon resonance sensor including: a plasmon polariton intensifying sensor chip in which a prism and a sensor chip including a transparent electrode, an n-type transparent semiconductor film, and a plasmon resonance film electrode arranged in this order are arranged in an order of the prism, the transparent electrode, the n-type transparent semiconductor film, and the plasmon resonance film electrode; and an electric measuring apparatus which directly measures a current or voltage from the transparent electrode and the plasmon resonance film electrode.

Abstract: A friction engagement device of an automatic transmission is provided, which includes a rotational member comprised of at least one of a drum member and a hub member including a spline part engaged with a friction plate to be movable in axial directions of the automatic transmission, and a drive force transmitting part for exchanging a drive force with another rotational element. The drive force transmitting part of the rotational member is made of a ferrous metal. A part of the rotational member other than the drive force transmitting part is made of a clad material containing a first material that is easily joined to the ferrous metal and a second material that is less easily joined to the ferrous metal compared to the first material and weighs less than the ferrous metal.

Abstract: [Problem] The present invention addresses the problem of providing a novel biomarker which makes it possible to find the prognosis of glioma, the risk of distant recurrence of glioma, the invasion ability of glioma cells and the like and also makes it possible to detect the prognosis, the risk, the invasion ability or the like in an earlier stage of a therapy of glioma. [Solution] The present invention relates to a method for evaluating the prognosis of glioma, said method comprising the steps of: detecting ACTC1 protein and/or mRNA encoding the protein in a glioma-containing sample collected from a patient; and determining that the prognosis of the glioma is poor when the ACTC1 protein and/or the mRNA encoding the protein is detected in the aforementioned step. According to the present invention, the prognosis of glioma, the risk of distant recurrence of glioma, the invasion ability and the like can be evaluated using a novel biomarker, i.e., ACTC1 protein and/or mRNA encoding the protein.

Abstract: The present invention relates to a life extension agent containing CD24-negative mesenchymal stem cells and the treatment of dementia, cerebral infarction, spinal cord injury and the like using the life extension agent.