Abstract: Provided is a processor including an instruction issue unit that issues a vector load instruction read from a main memory based on branch target prediction of a branch target in a branch instruction, a data acquisition unit that starts issue of a plurality of acquisition requests for acquiring a plurality of vector data based on the issued vector load instruction from the main memory, a determination unit that determines a success or a failure of the branch target prediction after the branch target is determined, and a vector load management unit that, when the branch target prediction is determined to be a success, acquires all vector data based on the plurality of acquisition requests and then transfers all the vector data to a vector register, and, when the branch target prediction is determined to be a failure, discards the vector data acquired by the issued acquisition requests.

Abstract: Provided is a processor including an instruction issue unit that issues a vector load instruction read from a main memory based on branch target prediction of a branch target in a branch instruction, a data acquisition unit that starts issue of a plurality of acquisition requests for acquiring a plurality of vector data based on the issued vector load instruction from the main memory, a determination unit that determines a success or a failure of the branch target prediction after the branch target is determined, and a vector load management unit that, when the branch target prediction is determined to be a success, acquires all vector data based on the plurality of acquisition requests and then transfers all the vector data to a vector register, and, when the branch target prediction is determined to be a failure, discards the vector data acquired by the issued acquisition requests.

Abstract: A method of highly efficiently transferring various selected molecules into various cells and a method of fusing cells. Cells and/or selected molecules such as polynucleotide are treated with cold gas plasma to thereby transfer the selected molecules located around cells into the cells, or cells are fused by treating the cells with cold gas plasma. Moreover, an apparatus for transferring selected molecules or fusing cells having a cold gas plasma generation unit for transferring selected molecules into cells is provided.

Abstract: The present invention relates to novel nuclear receptor ERR?3. Although ERR?3 itself lacks a DNA binding domain, it comprises the function of enhancing the transcriptional activation function of arbitrary nuclear receptors, such as ERR, ER, or TR. Moreover, the present inventors found that, like ERR?3, the known proteins ERR?1 and ERR?2 also comprise the function of enhancing the transcriptional activation function of other nuclear receptors. Thus, the present invention provides methods for evaluating the regulatory function of these ERR? subtypes in enhancing the transcriptional activation function of other nuclear receptors, and screening methods based on these evaluation methods.

Abstract: The present invention relates to the novel isoforms, RXR?2 and RXR?3, of nuclear receptor RXR?. Unlike known isoform RXR?1, the transcriptional activation functions of RXR?2 and RXR?3 are augmented by SRC-1. The present invention provides methods for evaluating the function of regulating augmentation by co-activators of these RXR? isoforms, and screening methods based on these evaluation methods. By controlling the interaction between isoforms and co-activators, transcription-controlling activity can be regulated in an isoform-specific manner.

Abstract: By using an entry number (WRB number) of a re-order buffer 6, each of function units such as an operation unit 3, a store unit 4, a load unit 5, etc. notifies to the re-order buffer 6 the processing end for a instruction stored in the entry concerned in the unit thereof. The load unit 5 manages the latest speculation state of a load instruction issued on the basis of a branch prediction success/failure signal output from the branch unit 2, and makes no notification to the re-order buffer 6 on the basis of WRB number for subsequent load instructions of a branch-prediction failed branch instruction even when the processing of the instruction is finished. Accordingly, the re-order buffer 6 can re-use entries in which the subsequent instructions of the branch prediction failed branch instruction are stored.

Abstract: A method of highly efficiently transferring various selected molecules into various cells and a method of fusing cells. Cells and/or selected molecules such as polynucleotide are treated with cold gas plasma to thereby transfer the selected molecules located around cells into the cells, or cells are fused by treating the cells with cold gas plasma. Moreover, an apparatus for transferring selected molecules or fusing cells having a cold gas plasma generation unit for transferring selected molecules into cells is provided.

Abstract: By using an entry number (WRB number) of a re-order buffer 6, each of function units such as an operation unit 3, a store unit 4, a load unit 5, etc. notifies to the re-order buffer 6 the processing end for a instruction stored in the entry concerned in the unit thereof. The load unit 5 manages the latest speculation state of a load instruction issued on the basis of a branch prediction success/failure signal output from the branch unit 2, and makes no notification to the re-order buffer 6 on the basis of WRB number for subsequent load instructions of a branch-prediction failed branch instruction even when the processing of the instruction is finished. Accordingly, the re-order buffer 6 can re-use entries in which the subsequent instructions of the branch prediction failed branch instruction are stored.

Abstract: The present invention provides a process for producing 7-aminocephem compounds or salts thereof.

Abstract: A cephalosporin C acylase from Pseudomonas diminuta N-176 is characterized by its ability to catalyze the conversion of cephalosporin C, glutaryl 7-ACA, adipyl 7-ACA, succinyl 7-ACA, N-acetylcephalosporin, N-benzoylcephalosporin C and cephalothin into 7-aminocephalosporanic acid. The enzyme contains an .alpha.-subunit having a molecular weight of 26 kDA and a .beta.-subunit having a molecular weight of 58 kDa. A method for the recombinant production of the present cephalosporin C acylase in Escherichia coli is provided.

Abstract: A GL-7ACA acylase having the following characteristics:(a) has ability to catalyze the enzymatic conversion of glutaryl 7-ACA, adipyl 7-ACA, and succinyl 7-ACA, into 7-aminocephalosporanic acid,(b) has a molecular weight of 70,000 dalton (SDS-PAGE) and(c) has N-terminal amino acid sequence (sea in No: 1) thereof: Gln-Ser-Glu-Gln-Glu-Lys-Ala-Glu-Glu-.A process for producing GL-7ACA acylase is also provided.

Abstract: A GL-7ACA acylase having the following characteristics:(a) has ability to catalyze the enzymatic conversion of glutaryl 7-ACA, adipyl 7-ACA, and succinyl 7-ACA, into 7-aminocephalosporanic acid,(b) has a molecular weight of 70,000 dalton (SDS-PAGE) and(c) has N-terminal amino acid sequence (SEQ ID NO: 1) thereof: Gln-Ser-Glu-Gln-Glu-Lys-Ala-Glu-Glu-.A process for producing GL-7ACA acylase is also provided.

Abstract: A cephalosporin C acylase from Pseudomonas diminuta N-176 is disclosed as well as the recombinant production of this enzyme in E. coli. The enzyme is characterized by the ability to catalyze the conversion of cephalosporin C, gultaryl 7-ACA, apidyl 7-ACA, succinyl 7-ACA, N-acetylcephalosporin C, N-benzoylcephalosporin C, and cephalothin into 7-aminocephalosporanic acid and is composed of an .alpha.-subunit with a molecular weight of 26,000 daltons and a .beta.-subunit with a molecular weight of 58,000 daltons.