Patents by Inventor Masao Kamahori

Masao Kamahori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10828861
    Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: November 10, 2020
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Yusuke Goto, Masao Kamahori, Hiroshi Sasaki, Kiyotoshi Mori, Hideyuki Akiyama
  • Publication number: 20190352699
    Abstract: The present invention is directed to provide new PCR measuring method and device. As one embodiment of the present invention, a DNA detection method for detecting DNA in a droplet being present in oil, the droplet containing the DNA and a fluorescent labeled probe, the fluorescent labeled probe being hybridized to the DNA, the method including: a first step of amplifying the DNA in the the droplet by a nucleic acid amplification reaction; and a second step of measuring a melting temperature of the fluorescent labeled probe and the DNA in the droplet is provided.
    Type: Application
    Filed: November 16, 2017
    Publication date: November 21, 2019
    Inventors: Junko TANAKA, Takahide YOKOI, Masao KAMAHORI, Yoshinobu KOHARA
  • Patent number: 10466214
    Abstract: In order to implement a high-sensitivity mass spectrometry through an improvement in solvent removal efficiency during electrospray ionization and the like, an ionization device is provided with a light guide path 28 which guides light from a light source to sample microparticles generated by a micronization device to irradiate the microparticles. A closest distance d2 between a spatial area 34 in which the sample microparticles are present and a distal end 29 of the light guide path is greater than or equal to 0.1 mm and less than or equal to 20 mm. A closest distance d1 between an area of light irradiation 35 by the light guide path and any of a sample surface, a micronization device, and a sample holding unit that is the closest is greater than or equal to 0.01 mm and less than or equal to 10 mm.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: November 5, 2019
    Assignee: HITACHI, LTD.
    Inventors: Masako Ishimaru, Masao Kamahori, Masuyuki Sugiyama, Kazushige Nishimura, Hiroyuki Satake, Hideki Hasegawa
  • Patent number: 10429363
    Abstract: In order to achieve high sensitivity without an increase in device complexity or cost, a far-ultraviolet absorbance detection device for liquid chromatography is provided with: an optical system including a light source that emits light including far-ultraviolet light, a diffraction grating for dispersing the light emitted from the light source, a flow cell through which a liquid is passed, a slit for selecting a predetermined wavelength of +1 order light diffracted by the diffraction grating and causing the light to enter the flow cell, a first photodetector for detecting the light transmitted by the flow cell, and a second photodetector for detecting light other than the +1 order light diffracted by the diffraction grating; a mechanism for evacuating or substituting the optical system with nitrogen gas; and a computation unit that calculates absorbance from an output signal from the first photodetector and an output signal from the second photodetector. The second photodetector is fixedly disposed.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: October 1, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yuichi Uchiho, Masao Kamahori, Toshimichi Aota
  • Publication number: 20180284083
    Abstract: In order to implement a high-sensitivity mass spectrometry through an improvement in solvent removal efficiency during electrospray ionization and the like, an ionization device is provided with a light guide path 28 which guides light from a light source to sample microparticles generated by a micronization device to irradiate the microparticles. A closest distance d2 between a spatial area 34 in which the sample microparticles are present and a distal end 29 of the light guide path is greater than or equal to 0.1 mm and less than or equal to 20 mm. A closest distance d1 between an area of light irradiation 35 by the light guide path and any of a sample surface, a micronization device, and a sample holding unit that is the closest is greater than or equal to 0.01 mm and less than or equal to 10 mm.
    Type: Application
    Filed: December 9, 2015
    Publication date: October 4, 2018
    Inventors: Masako ISHIMARU, Masao KAMAHORI, Masuyuki SUGIYAMA, Kazushige NISHIMURA, Hiroyuki SATAKE, Hideki HASEGAWA
  • Publication number: 20180244015
    Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.
    Type: Application
    Filed: May 1, 2018
    Publication date: August 30, 2018
    Inventors: Yusuke GOTO, Masao KAMAHORI, Hiroshi SASAKI, Kiyotoshi MORI, Hideyuki AKIYAMA
  • Publication number: 20180244014
    Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.
    Type: Application
    Filed: May 1, 2018
    Publication date: August 30, 2018
    Inventors: Yusuke GOTO, Masao KAMAHORI, Hiroshi SASAKI, Kiyotoshi MORI, Hideyuki AKIYAMA
  • Patent number: 10018585
    Abstract: An electrolyte concentration measuring apparatus is provided with: a plurality of ion selective electrodes and one reference electrode; a sample introduction unit that introduces a sample solution to the plurality of ion selective electrodes and the reference electrode; a potential measuring unit that measures a voltage between the plurality of ion selective electrodes and the reference electrode; and a resistance measuring unit that measures a direct-current resistance of the plurality of ion selective electrodes.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: July 10, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yu Ishige, Masao Kamahori, Atsushi Kishioka, Tetsuyoshi Ono, Masafumi Miyake
  • Patent number: 9975308
    Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: May 22, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yusuke Goto, Masao Kamahori, Hiroshi Sasaki, Kiyotoshi Mori, Hideyuki Akiyama
  • Patent number: 9885683
    Abstract: To enhance the potential stability of a solid-electrode-type ion-selective electrode and reduce individual variations, the present invention is provided with an ion-sensitive membrane adapted to be in contact with a measurement solution, a mixture of graphite and liquid oil that is in contact with the ion-sensitive membrane, and a conductor that is in contact with the mixture of graphite and liquid oil.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: February 6, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yu Ishige, Masao Kamahori, Tetsuyoshi Ono, Yusuke Goto
  • Patent number: 9658153
    Abstract: To prevent lowering of sensitivity of a flow cell based on total reflection of light at an outer face of a glass capillary at a joint part with a pipe, the flow cell includes, at joint parts with a pipe 605 to introduce solution to a glass capillary 601 and with a pipe to discharge solution from the capillary, an inorganic material layer 602 that reflects measurement light to modify the outer face of the glass capillary as well as a reinforcement layer 711 to modify the surface thereof.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: May 23, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yusuke Goto, Masao Kamahori, Yu Ishige, Hiroshi Sasaki, Hideyuki Akiyama, Shintaro Kubo
  • Patent number: 9541531
    Abstract: A detector for liquid chromatography has light sources that generate light in an ultraviolet region and in a near-infrared region; a flow cell, through which sample liquid flows; an optical system to let light generated from the light sources become incident on the flow cell concurrently; a detection element that detects light in the ultraviolet region that passes through the flow cell; a detection element that detects light in the near-infrared region that passes through the flow cell; and an arithmetic operation part that performs arithmetic operation of a first signal value obtained from the detection element and of a second signal value obtained from the detection element. The arithmetic operation part combines the first signal value and the second signal value to calculate a signal value with a reduced baseline fluctuation resulting from a mobile phase during a gradient analysis.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: January 10, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Yusuke Goto, Masao Kamahori, Kiyotoshi Mori
  • Publication number: 20160258913
    Abstract: In order to achieve high sensitivity without an increase in device complexity or cost, a far-ultraviolet absorbance detection device for liquid chromatography is provided with: an optical system including a light source that emits light including far-ultraviolet light, a diffraction grating for dispersing the light emitted from the light source, a flow cell through which a liquid is passed, a slit for selecting a predetermined wavelength of +1 order light diffracted by the diffraction grating and causing the light to enter the flow cell, a first photodetector for detecting the light transmitted by the flow cell, and a second photodetector for detecting light other than the +1 order light diffracted by the diffraction grating; a mechanism for evacuating or substituting the optical system with nitrogen gas; and a computation unit that calculates absorbance from an output signal from the first photodetector and an output signal from the second photodetector. The second photodetector is fixedly disposed.
    Type: Application
    Filed: February 4, 2016
    Publication date: September 8, 2016
    Inventors: Yuichi UCHIHO, Masao KAMAHORI, Toshimichi AOTA
  • Publication number: 20160223486
    Abstract: To enhance the potential stability of a solid-electrode-type ion-selective electrode and reduce individual variations, the present invention is provided with an ion-sensitive membrane adapted to be in contact with a measurement solution, a mixture of graphite and liquid oil that is in contact with the ion-sensitive membrane, and a conductor that is in contact with the mixture of graphite and liquid oil.
    Type: Application
    Filed: July 28, 2014
    Publication date: August 4, 2016
    Inventors: Yu ISHIGE, Masao KAMAHORI, Tetsuyoshi ONO, Yusuke GOTO
  • Publication number: 20160054257
    Abstract: An electrolyte concentration measuring apparatus is provided with: a plurality of ion selective electrodes and one reference electrode; a sample introduction unit that introduces a sample solution to the plurality of ion selective electrodes and the reference electrode; a potential measuring unit that measures a voltage between the plurality of ion selective electrodes and the reference electrode; and a resistance measuring unit that measures a direct-current resistance of the plurality of ion selective electrodes.
    Type: Application
    Filed: April 10, 2014
    Publication date: February 25, 2016
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Yu ISHIGE, Masao KAMAHORI, Atsushi KISHIOKA, Tetsuyoshi ONO, Masafumi MIYAKE
  • Publication number: 20150314550
    Abstract: A composite structure with high pressure resistance that is suitable for a flow channel is produced by reducing the number of components while maintaining the excellent chemical resistance and high stress tolerance inherent to a glass substrate and a resin substrate. A glass substrate surface is modified with a hydrolyzable silicon compound, and the glass substrate is brought into contact with the resin substrate. Subsequently, the contact surface between the glass substrate and the resin substrate is heated to a temperature from the glass transition temperature to the pyrolysis temperature of the resin substrate, eliminating gaps between the glass substrate and the resin substrate to bring them into close contact with each other, and causing chemical binding or anchor effects between the glass substrate and the resin substrate via the hydrolyzable silicon compound. Thus, the glass substrate and the resin substrate are firmly fixed to each other.
    Type: Application
    Filed: November 1, 2013
    Publication date: November 5, 2015
    Inventors: Yusuke GOTO, Masao KAMAHORI, Hiroshi SASAKI, Kiyotoshi MORI, Hideyuki AKIYAMA
  • Publication number: 20150090014
    Abstract: A detector for liquid chromatography has light sources that generate light in an ultraviolet region and in a near-infrared region; a flow cell, through which sample liquid flows; an optical system to let light generated from the light sources become incident on the flow cell concurrently; a detection element that detects light in the ultraviolet region that passes through the flow cell; a detection element that detects light in the near-infrared region that passes through the flow cell; and an arithmetic operation part that performs arithmetic operation of a first signal value obtained from the detection element and of a second signal value obtained from the detection element. The arithmetic operation part combines the first signal value and the second signal value to calculate a signal value with a reduced baseline fluctuation resulting from a mobile phase during a gradient analysis.
    Type: Application
    Filed: September 5, 2014
    Publication date: April 2, 2015
    Inventors: Yusuke GOTO, Masao KAMAHORI, Kiyotoshi MORI
  • Publication number: 20140332674
    Abstract: To prevent lowering of sensitivity of a flow cell based on total reflection of light at an outer face of a glass capillary at a joint part with a pipe, the flow cell includes, at joint parts with a pipe 605 to introduce solution to a glass capillary 601 and with a pipe to discharge solution from the capillary, an inorganic material layer 602 that reflects measurement light to modify the outer face of the glass capillary as well as a reinforcement layer 711 to modify the surface thereof.
    Type: Application
    Filed: October 30, 2012
    Publication date: November 13, 2014
    Inventors: Yusuke Goto, Masao Kamahori, Yu Ishige, Hiroshi Sasaki, Hideyuki Akiyama, Shintaro Kubo
  • Patent number: 8712701
    Abstract: Provided is a potentiometric sensor chip in which the positional relationship among a reference electrode, a measurement electrode, and a sample inlet which enables measurement from the start of a reaction is defined, and further provided is a method for detecting the start time of the reaction. A very small amount of sample is measured with high accuracy. The very small quantity of sample is measured by a rate assay. When a reference electrode (103) is disposed between a sample inlet (102) and a measurement electrode (104), a sample solution arrives at the reference electrode (103) earlier than at the measurement electrode (104), whereby the surface potential of the measurement electrode (104) can be measured simultaneously when the sample solution arrives at the measurement electrode (104) and dissolves a reagent and thereby a reaction starts.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: April 29, 2014
    Assignee: Hitachi, Ltd.
    Inventors: Yu Ishige, Masao Kamahori, Kuniaki Nagamine
  • Patent number: 8702933
    Abstract: A potentiometric sensor with suppressed leak current on the surface of an electrode and improved for a dynamic range and a response speed, in which a redox compound is immobilized through insulative molecules on the surface of a gold electrode, and a current between a source and drain of an insulated gate field-effect transistor along with reaction between an oxidized substance or a reduced substance produced by the reaction of a measured substance in a sample solution injector for supplying the sample solution containing the measured substance and an enzyme and a redox compound on the surface of the gold electrode, is monitored on real time to measure the change of the surface potential.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: April 22, 2014
    Assignee: Hitachi, Ltd.
    Inventors: Yu Ishige, Masao Kamahori